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Lysophosphatidic acid receptor 1 antagonist (EPGN2154) causes regression of NASH in preclinical NASH models.

Autor: Bhattacharjee J; Department of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Los Angeles, California, USA., Beaton G; Epigen Biosciences Inc., San Diego, California, USA., Ravula SB; Epigen Biosciences Inc., San Diego, California, USA., Lee SJ; Epigen Biosciences Inc., San Diego, California, USA., Bacon KB; Epigen Biosciences Inc., San Diego, California, USA., Jenkinson CP; Epigen Biosciences Inc., San Diego, California, USA., Warren M; Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA., Tucci FC; Epigen Biosciences Inc., San Diego, California, USA., Kohli R; Department of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Los Angeles, California, USA.

Publikováno v: Hepatology communications [Hepatol Commun] 2023 Nov 22; Vol. 7 (12). Date of Electronic Publication: 2023 Nov 22 (Print Publication: 2023).

Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state.

Autor: Woller SA; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA; Department of Medicine, Division of Rheumatology, Allergy, and Immunology, University of California San Diego, La Jolla, CA, USA. Electronic address: swoller@ucsd.edu., Ravula SB; Epigen Biosciences Inc., 10225 Barnes Canyon Road, Suite A104, San Diego, CA 92121, USA. Electronic address: sravula@epigenbiosciences.com., Tucci FC; Epigen Biosciences Inc., 10225 Barnes Canyon Road, Suite A104, San Diego, CA 92121, USA. Electronic address: ftucci@epigenbiosciences.com., Beaton G; Epigen Biosciences Inc., 10225 Barnes Canyon Road, Suite A104, San Diego, CA 92121, USA. Electronic address: gbeaton@epigenbiosciences.com., Corr M; Department of Medicine, Division of Rheumatology, Allergy, and Immunology, University of California San Diego, La Jolla, CA, USA. Electronic address: mpcorr@ucsd.edu., Isseroff RR; Department of Dermatology, School of Medicine, University of California, Davis, CA, USA. Electronic address: rrisseroff@ucdavis.edu., Soulika AM; Department of Dermatology, School of Medicine, University of California, Davis, CA, USA; Shriners Hospital for Children, Northern California, Sacramento, CA, USA. Electronic address: asoulika@ucdavis.edu., Chigbrow M; Department of Dermatology, School of Medicine, University of California, Davis, CA, USA. Electronic address: mchigbrow@ucdavis.edu., Eddinger KA; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA. Electronic address: keddinger@ucsd.edu., Yaksh TL; Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA. Electronic address: tyaksh@ucsd.edu.

Publikováno v: Brain, behavior, and immunity [Brain Behav Immun] 2016 Aug; Vol. 56, pp. 271-80. Date of Electronic Publication: 2016 Apr 01.

Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H₁-antihistamines for insomnia.

Autor: Ravula SB; Neurocrine Biosciences, 12780 El Camino Real, San Diego, CA 92130, USA. satheesh.ravula@gmail.com, Yu J, Tran JA, Arellano M, Tucci FC, Moree WJ, Li BF, Petroski RE, Wen J, Malany S, Hoare SR, Madan A, Crowe PD, Beaton G

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Jan 01; Vol. 22 (1), pp. 421-6. Date of Electronic Publication: 2011 Nov 15.