Výsledky vyhledávání - "Ravindranath Nasi"

Sialyltransferase inhibitors: consideration of molecular shape and charge/hydrophobic interactions

Autor: Rishi Kumar, Nam Huan Khieu, Milan Bhasin, Harold C. Jarrell, Wei Zou, Michel Gilbert, Margaret Hsieh, Harold J. Jennings, Ravindranath Nasi

Publikováno v: Carbohydrate Research. 378:45-55

In order to evaluate the importance of molecular shape of inhibitor molecules and the charge/H-bond and hydrophobic interactions, we synthesized three types of molecules and tested them against a sialyltransferase. The first type of compounds were de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e081e337033f4db78eee1bef814818a8
https://doi.org/10.1016/j.carres.2012.12.017

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New Glucosidase Inhibitors from an Ayurvedic Herbal Treatment for Type 2 Diabetes: Structures and Inhibition of Human Intestinal Maltase-Glucoamylase with Compounds from Salacia reticulata

Autor: Ravindranath Nasi, Lyann Sim, Kumarasamy Jayakanthan, David R. Rose, Blair D. Johnston, B. M. Pinto, Sankar Mohan

Publikováno v: Biochemistry. 49:443-451

An approach to controlling blood glucose levels in individuals with type 2 diabetes is to target alpha-amylases and intestinal glucosidases using alpha-glucosidase inhibitors acarbose and miglitol. One of the intestinal glucosidases targeted is the N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146c031e098616997fe95faf8a9fa12b
https://doi.org/10.1021/bi9016457

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New Synthetic Routes to Chain-Extended Selenium, Sulfur, and Nitrogen Analogues of the Naturally Occurring Glucosidase Inhibitor Salacinol and their Inhibitory Activities against Recombinant Human Maltase Glucoamylase

Autor: Heather Heipel, Ravindranath Nasi, Lyann Sim, Hui Liu, David R. Rose, B Mario Pinto, Kumarasamy Jayakanthan

Publikováno v: The Journal of Organic Chemistry. 72:6562-6572

Six heteroanalogues (X = S, Se, NH) of the naturally occurring glucosidase inhibitor salacinol, containing polyhydroxylated, acyclic chains of 6-carbons, were synthesized for structure-activity studies with different glycosidase enzymes. The target z

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab328052d93b3aca7e608204dd781d4e
https://doi.org/10.1021/jo071045m

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New Chain-Extended Analogues of Salacinol and Blintol and Their Glycosidase Inhibitory Activities. Mapping the Active-Site Requirements of Human Maltase Glucoamylase

Autor: Ravindranath Nasi, Lyann Sim, David R. Rose, B Mario Pinto

Publikováno v: The Journal of Organic Chemistry. 72:180-186

The synthesis of new chain-extended sulfonium and selenonium salts of 1,4-anhydro-4-thio-(or 4-seleno)-d-arabinitol, analogues of the naturally occurring glycosidase inhibitor salacinol, is described. Nucleophilic attack at the least hindered carbon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa030050ab7284322b9778761fce94b
https://doi.org/10.1021/jo061944v

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Synthesis and biological evaluation of heteroanalogues of kotalanol and de-O-sulfonated kotalanol

Autor: Sankar Mohan, David R. Rose, Douglas A. Kuntz, B Mario Pinto, Kumarasamy Jayakanthan, Ravindranath Nasi

Publikováno v: Organic letters. 12(5)

The synthesis of nitrogen and selenium analogues of kotalanol and de-O-sulfonated kotalanol, naturally occurring sulfonium-ion glucosidase inhibitors isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against the N-termi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e9a107a72776016423027fc2791aec
https://pubmed.ncbi.nlm.nih.gov/20143790

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Studies directed toward the stereochemical structure determination of the naturally occurring glucosidase inhibitor, kotalanol: synthesis and inhibitory activities against human maltase glucoamylase of seven-carbon, chain-extended homologues of salacinol

Autor: Ravindranath Nasi, B. Mario Pinto, David R. Rose, Brian O. Patrick, Lyann Sim

Publikováno v: The Journal of organic chemistry. 73(16)

The synthesis of new seven-carbon, chain-extended sulfonium salts of 1,4-anhydro-4-thio- d-arabinitol, analogues of the naturally occurring glycosidase inhibitor salacinol, are described. These compounds were designed on the basis of the structure ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb06276ab9a248191839ce21bf7539c
https://pubmed.ncbi.nlm.nih.gov/18651773

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Synthesis and glycosidase inhibitory activities of chain-modified analogues of the glycosidase inhibitors salacinol and blintol

Autor: Ravindranath Nasi, B. Mario Pinto, David R. Rose, Lyann Sim

Publikováno v: Carbohydrate research. 342(12-13)

The synthesis of chain-modified analogues of the naturally-occurring glycosidase inhibitor, salacinol, and its selenium analogue, blintol is described. The modification consists of a frame shift of the sulfate moiety by one carbon atom in the zwitter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fead822bcca6a28645a17d298c79660
https://pubmed.ncbi.nlm.nih.gov/17359953

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Synthesis of new analogues of salacinol containing a pendant hydroxymethyl group as potential glycosidase inhibitors

Autor: Ravindranath Nasi, B. Mario Pinto

Publikováno v: Carbohydrate research. 341(14)

The synthesis of new analogues of the naturally occurring glycosidase inhibitor, salacinol, and its ammonium analogue, ghavamiol is described. These analogues contain an additional hydroxymethyl group at C-1, which was intended to form additional pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888b8d2e63384308b35fb94ec0dece46
https://pubmed.ncbi.nlm.nih.gov/16854397

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