Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Ravindra, Majeti"'
Autor:
Kevin Nuno, Armon Azizi, Thomas Koehnke, Caleb Lareau, Asiri Ediriwickrema, M Ryan Corces, Ansuman T Satpathy, Ravindra Majeti
Publikováno v:
eLife, Vol 13 (2024)
Relapse of acute myeloid leukemia (AML) is highly aggressive and often treatment refractory. We analyzed previously published AML relapse cohorts and found that 40% of relapses occur without changes in driver mutations, suggesting that non-genetic me
Externí odkaz:
https://doaj.org/article/427e2ac74ef04fbe9a20d997243da060
Autor:
Amy C. Fan, Yusuke Nakauchi, Lawrence Bai, Armon Azizi, Kevin A. Nuno, Feifei Zhao, Thomas Köhnke, Daiki Karigane, David Cruz-Hernandez, Andreas Reinisch, Purvesh Khatri, Ravindra Majeti
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Disease-initiating mutations in the transcription factor RUNX1 occur as germline and somatic events that cause leukemias with particularly poor prognosis. However, the role of RUNX1 in leukemogenesis is not fully understood, and effective therapies f
Externí odkaz:
https://doaj.org/article/9d67e910a2aa4c2186e242f58f9edee6
Autor:
Mahmoud A. Bassal, Saumya E. Samaraweera, Kelly Lim, Brooks A. Bernard, Sheree Bailey, Satinder Kaur, Paul Leo, John Toubia, Chloe Thompson-Peach, Tran Nguyen, Kyaw Ze Ya Maung, Debora A. Casolari, Diana G. Iarossi, Ilaria S. Pagani, Jason Powell, Stuart Pitson, Siria Natera, Ute Roessner, Ian D. Lewis, Anna L. Brown, Daniel G. Tenen, Nirmal Robinson, David M. Ross, Ravindra Majeti, Thomas J. Gonda, Daniel Thomas, Richard J. D’Andrea
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Mitochondrial metabolism has been associated with tumourigenesis in acute myeloid leukaemia (AML) and currently considered as a potential therapeutic target. Here, the authors show, in patients with AML, that germline mutations in mitochondrial compl
Externí odkaz:
https://doaj.org/article/80997f20894a4c6ab09d4081863d91de
Autor:
Yu-Chen Lo, Timothy J. Keyes, Astraea Jager, Jolanda Sarno, Pablo Domizi, Ravindra Majeti, Kathleen M. Sakamoto, Norman Lacayo, Charles G. Mullighan, Jeffrey Waters, Bita Sahaf, Sean C. Bendall, Kara L. Davis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Challenges in batch normalization and data integration limit the comparison of existing mass cytometry datasets. Here, the authors report CytofIn that can integrate mass cytometry datasets from the public domain and reveal cellular features associate
Externí odkaz:
https://doaj.org/article/62feaf98a89e4b25a5f743a4912683d7
Autor:
Brooks A. Benard, Logan B. Leak, Armon Azizi, Daniel Thomas, Andrew J. Gentles, Ravindra Majeti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Individual studies have been underpowered to draw clear associations between clonal heterogeneity and response to therapy in acute myeloid leukemia (AML). Here, the authors aggregate multiple AML cohorts and are able to correlate the clonal abundance
Externí odkaz:
https://doaj.org/article/a4b271e40ef04eaa869544eebbd2896e
Autor:
Rajiv Sharma, Daniel P. Dever, Ciaran M. Lee, Armon Azizi, Yidan Pan, Joab Camarena, Thomas Köhnke, Gang Bao, Matthew H. Porteus, Ravindra Majeti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Genetic barcoding has been used to track clonal dynamics of cells. Here, the authors develop a Tracking Recombination Alleles in Clonal Engraftment using sequencing (TRACE-Seq), to barcode repaired alleles by introducing silent mutations or outside o
Externí odkaz:
https://doaj.org/article/24227f1bebe84818bfcc9151aa481b5d
Autor:
Michael A. Koldobskiy, Jordi Abante, Garrett Jenkinson, Elisabet Pujadas, Ashley Tetens, Feifei Zhao, Rakel Tryggvadottir, Adrian Idrizi, Andreas Reinisch, Ravindra Majeti, John Goutsias, Andrew P. Feinberg
Publikováno v:
Epigenetics, Vol 15, Iss 8, Pp 841-858 (2020)
Translocations of the KMT2A (MLL) gene define a biologically distinct and clinically aggressive subtype of acute myeloid leukaemia (AML), marked by a characteristic gene expression profile and few cooperating mutations. Although dysregulation of the
Externí odkaz:
https://doaj.org/article/492a9c76f8d946b29e69b4fde8834c85
Autor:
Mahmoud A. Bassal, Saumya E. Samaraweera, Kelly Lim, Brooks A. Benard, Sheree Bailey, Satinder Kaur, Paul Leo, John Toubia, Chloe Thompson-Peach, Tran Nguyen, Kyaw Ze Ya Maung, Debora A. Casolari, Diana G. Iarossi, Ilaria S. Pagani, Jason Powell, Stuart Pitson, Siria Natera, Ute Roessner, Ian D. Lewis, Anna L. Brown, Daniel G. Tenen, Nirmal Robinson, David M. Ross, Ravindra Majeti, Thomas J. Gonda, Daniel Thomas, Richard J. D’Andrea
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/358e6495258e4f5ea0b4793e347e5337
Autor:
Andriana G. Kotini, Saul Carcamo, Nataly Cruz-Rodriguez, Malgorzata Olszewska, Tiansu Wang, Deniz Demircioglu, Chan-Jung Chang, Elsa Bernard, Mark P. Chao, Ravindra Majeti, Hanzhi Luo, Michael G. Kharas, Dan Hasson, Eirini P. Papapetrou
Publikováno v:
Blood Cancer Discovery. :OF1-OF18
The reprogramming of human acute myeloid leukemia (AML) cells into induced pluripotent stem cell (iPSC) lines could provide new faithful genetic models of AML, but is currently hindered by low success rates and uncertainty about whether iPSC-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e509ad52fba71aa507e7a6b94bb331a
https://doi.org/10.1158/2643-3230.bcd-22-0167
https://doi.org/10.1158/2643-3230.bcd-22-0167
Autor:
Miles H. Linde, Amy C. Fan, Thomas Köhnke, Aaron C. Trotman-Grant, Sarah F. Gurev, Paul Phan, Feifei Zhao, Naomi L. Haddock, Kevin A. Nuno, Eric J. Gars, Melissa Stafford, Payton L. Marshall, Christopher G. Dove, Ian L. Linde, Niklas Landberg, Lindsay P. Miller, Robbie G. Majzner, Tian Yi Zhang, Ravindra Majeti
Publikováno v:
Cancer Discovery. 13:1164-1185
Therapeutic cancer vaccination seeks to elicit activation of tumor-reactive T cells capable of recognizing tumor-associated antigens (TAA) and eradicating malignant cells. Here, we present a cancer vaccination approach utilizing myeloid-lineage repro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48f8e395fc6fed56549e4330f15d5fb6
https://doi.org/10.1158/2159-8290.cd-21-0502
https://doi.org/10.1158/2159-8290.cd-21-0502