Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ravinder Reddy Gaddam"'
Autor:
Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S. Jacobs, Markus M. Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J. Rauckhorst, Eric B. Taylor, Andrew W. Norris, Ajit Vikram, Kaikobad Irani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Downregulation of endothelial Sirtuin1 (Sirt1) in insulin resistant states contributes to vascular dysfunction. Furthermore, Sirt1 deficiency in skeletal myocytes promotes insulin resistance. Here, we show that deletion of endothelial Sirt1,
Externí odkaz:
https://doaj.org/article/72b47199e1ba4328a43cb9d21627ccbf
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/06e6c26a81a645eaa40ea75bcdd0f22c
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 84 (2024)
The activation of Kupffer cells, resident macrophages in the liver, is closely associated with the inflammatory response during sepsis, which leads to multiple-organ failure. However, how Kupffer cell activation affects adhesion molecules (ICAM-1 and
Externí odkaz:
https://doaj.org/article/df8a851b27ad42f09a85dbd0bd2da540
Autor:
Ravinder Reddy Gaddam, Young‐Rae Kim, Julia S. Jacobs, Jin‐Young Yoon, Qiuxia Li, Angela Cai, Hamsitha Shankaiahgari, Barry London, Kaikobad Irani, Ajit Vikram
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 1, Pp n/a-n/a (2022)
Background MicroRNAs regulate cardiac hypertrophy development, which precedes and predicts the risk of heart failure. microRNA‐204‐5p (miR‐204) is well expressed in cardiomyocytes, but its role in developing cardiac hypertrophy and cardiac dysf
Externí odkaz:
https://doaj.org/article/c8bea0cb37fd464bbb84ca559afe785c
Autor:
Chayanika Gundu, Vijay Kumar Arruri, Poonam Yadav, Umashanker Navik, Ashutosh Kumar, Veda Sudhir Amalkar, Ajit Vikram, Ravinder Reddy Gaddam
Publikováno v:
Cells, Vol 11, Iss 16, p 2557 (2022)
Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase dynamin acts as a “molecular scissor” to form endocytic vesicles and is
Externí odkaz:
https://doaj.org/article/2875ff20fa1041cb813789221ebebeb7
Publikováno v:
Cells, Vol 10, Iss 11, p 3097 (2021)
microRNAs (miRs) are emerging as attractive therapeutic targets because of their small size, specific targetability, and critical role in disease pathogenesis. However,
Externí odkaz:
https://doaj.org/article/8d2384e466034a058851f9185a462798
Autor:
Ravinder Reddy Gaddam, Robin Fraser, Alireza Badiei, Stephen Chambers, Victoria C Cogger, David G Le Couteur, Isao Ishii, Madhav Bhatia
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183304 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0160521.].
Externí odkaz:
https://doaj.org/article/73e5ead90f6f4c88b82f84c724024543
Autor:
Ravinder Reddy Gaddam, Robin Fraser, Alireza Badiei, Stephen Chambers, Victoria C Cogger, David G Le Couteur, Isao Ishii, Madhav Bhatia
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160521 (2016)
Hydrogen sulfide (H2S), produced by the activity of cystathionine-gamma-lyase (CSE), is a key mediator of inflammation in sepsis. The liver sinusoidal endothelial cells (LSECs) are important target and mediator of sepsis. The aim of this study was to
Externí odkaz:
https://doaj.org/article/d2daf74bec0744d2851f0e3b02c97af8
Supplementary data files
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6af118df4a8c842eac122c8f7efd27
https://doi.org/10.1158/0008-5472.22429965
https://doi.org/10.1158/0008-5472.22429965
miRNA-155 (miR-155) is overexpressed in various types of lymphomas and leukemias, suggesting that targeting miR-155 could be a potential platform for the development of precision medicine. Here, we tested the anticancer activity of novel, chemically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3121fb474b6c1bc66045b8c3f1d0a1c7
https://doi.org/10.1158/0008-5472.c.6513501.v1
https://doi.org/10.1158/0008-5472.c.6513501.v1