Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Ravinder Nath Maini"'
Autor:
Marc Feldmann, Ravinder Nath Maini
Publikováno v:
Arthritis & Rheumatology. 67:2283-2291
Autor:
Ewa M. Paleolog, P T Chapman, M Feldmann, M J Elliott, R V McCloskey, Peter C. Taylor, Ravinder Nath Maini, A. M. Peters
OBJECTIVE: To verify the hypothesis that in rheumatoid arthritis (RA), tumor necrosis factor alpha (TNFalpha) plays a critical role in regulating leukocyte trafficking and chemokine levels. METHODS: Ten patients with longstanding RA received a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53610335da45836b17bd254ddeb1051e
https://ora.ox.ac.uk/objects/uuid:a7d6a7d9-3e3b-4a86-8cda-0d59b1724fe6
https://ora.ox.ac.uk/objects/uuid:a7d6a7d9-3e3b-4a86-8cda-0d59b1724fe6
While it is apparent that much more needs to be learnt about T cells in RA, it seems evident that because of their central role in the immunoregulation their study will provide a lot of valuable information concerning the pathogenesis and perhaps eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e78d1eb88b1689aa8479577d629ee1
https://doi.org/10.1007/bf01857221
https://doi.org/10.1007/bf01857221
Autor:
Ferdinand C. Breedveld, Peter C. Taylor, A. E. Meinders, T. J. M. Smeets, Paul P. Tak, Philip M. Kluin, Mohamed R. Daha, Ravinder Nath Maini
OBJECTIVE: The effect of chimeric anti-tumor necrosis factor alpha (TNF alpha) monoclonal antibody (MAb) therapy on synovial inflammation was studied in order to address the hypothesis that anti-TNF alpha therapy leads to down-regulation of adhesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4749d2740ba6de3d7438fe5d47119540
https://ora.ox.ac.uk/objects/uuid:655bc469-01a2-47fc-abff-d2202d3b3011
https://ora.ox.ac.uk/objects/uuid:655bc469-01a2-47fc-abff-d2202d3b3011
Matrix metalloproteinase (MMP)-1 and MMP-3 levels were measured in serum samples from rheumatoid arthritis (RA) patients undergoing a double-blinded placebo-controlled trial with the chimaeric anti-tumour necrosis factor (TNF)-alpha antibody cA2. Bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0e1470da42ae749a0b20432a0831dc
https://ora.ox.ac.uk/objects/uuid:398817cf-2ecb-4b72-9fa0-ab5721edb6f4
https://ora.ox.ac.uk/objects/uuid:398817cf-2ecb-4b72-9fa0-ab5721edb6f4
Autor:
Marc Feldmann, Ravinder Nath Maini, D. Gibbons, Lynn M. Williams, A Gearing, Fionula M. Brennan
We have previously hypothesized that the pro-inflammatory cytokine TNF alpha has a pivotal role in the pathogenesis of rheumatoid arthritis (RA). It mediates its effects by cross-linking surface p55 TNF receptors (TNF-R), which can be proteolytically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e469b13faca37ca99f50f9fba337ece9
https://ora.ox.ac.uk/objects/uuid:74c87ad6-dea2-42dc-9678-873bf7ef5d8c
https://ora.ox.ac.uk/objects/uuid:74c87ad6-dea2-42dc-9678-873bf7ef5d8c
Autor:
Marc Feldmann, D H Presky, Debra M. Butler, Anne-Marie Malfait, Fionula M. Brennan, Ravinder Nath Maini
SUMMARYThe effect of blocking IL-12, a potent inducer of interferon-gamma (IFN-γ) and promoter of Th1 cell responses, during the induction phase of CIA was investigated. Arthritis was elicited in male DBA/1 mice by immunizing with type II collagen (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2fb33a45d26f36346921fca0571bdf
https://doi.org/10.1046/j.1365-2249.1998.00485.x
https://doi.org/10.1046/j.1365-2249.1998.00485.x
Autor:
Arthur Kavanaugh, David Baker, F. C. Breedveld, D. van der Heijde, Mohan Bala, Ravinder Nath Maini, C. Han, Peter E. Lipsky
Publikováno v:
Annals of the Rheumatic Diseases. 64:52-55
Objectives: To identify factors associated with poor physical function in rheumatoid arthritis and to assess whether baseline joint damage has an impact on improvement in physical function during infliximab treatment. Methods: 428 patients with activ
Autor:
J. R. Kalden, E W St Clair, Ravinder Nath Maini, F. C. Breedveld, Josef S Smolen, Paul A. Marsters, D. van der Heijde, Gregory Keenan, Peter E. Lipsky, Daniel E. Furst, Michael H. Weisman
Publikováno v:
Arthritis & Rheumatism. 50:1051-1065
Objective To evaluate the efficacy and safety of repeated administration of infliximab plus methotrexate (MTX) over a 2-year period in patients with rheumatoid arthritis (RA) who previously experienced an incomplete response to MTX. Methods Four hund
Autor:
M Weisman, Marc Feldmann, J. R. Kalden, E W St Clair, F. C. Breedveld, Daniel E. Furst, Ravinder Nath Maini, Peter E. Lipsky, Paul Emery, Josef S. Smolen, Gregory Harriman, D. van der Heijde
Publikováno v:
New England Journal of Medicine. 343:1594-1602
Background: Neutralization of tumor necrosis factor α (TNF-α) for three to six months reduces the symptoms and signs of rheumatoid arthritis. However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage a