Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Ravinder N. Maini"'
Autor:
Ravinder N. Maini, Marc Feldmann
Publikováno v:
Immune Modulating Agents ISBN: 9781003064671
Immune Modulating Agents
Immune Modulating Agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97bb944d4f88e0035df90fc303ab7195
https://doi.org/10.1201/9781003064671-24
https://doi.org/10.1201/9781003064671-24
Autor:
Marc Feldmann, Matthew J. Rowland, Tracy Hussell, Gregory Paul Winter, Stephen T. Holgate, Ravinder N. Maini, James N. Woody, Duncan Richards
Publikováno v:
The Lancet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b775ff8dfb0ef025066f6e7e834a27fa
https://doi.org/10.1016/s0140-6736(20)30858-8
https://doi.org/10.1016/s0140-6736(20)30858-8
Autor:
Josef S Smolen, Burkhard F. Leeb, Thomas F. Schaible, Ravinder N. Maini, Ferdinand C. Breedveld, C Antoni, M J Elliott, Marc Feldmann, Joachim R. Kalden, James N. Woody, Diana Davis, John D. Macfarlane
OBJECTIVE: To evaluate the efficacy, pharmacokinetics, immunogenicity, and safety of multiple infusions of a chimeric monoclonal anti-tumor necrosis factor alpha antibody (cA2) (infliximab; Remicade, Centocor, Malvern, PA) given alone or in combinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1e91ab0dbab56470fe0c95b3dd9941
https://ora.ox.ac.uk/objects/uuid:b6cd2920-1f1e-459a-a290-55e23d9d26e6
https://ora.ox.ac.uk/objects/uuid:b6cd2920-1f1e-459a-a290-55e23d9d26e6
Autor:
Marc Feldmann, Richard O. Williams, Lilia Marinova-Mutafchieva, Ravinder N. Maini, Lesley J. Mason, Claudia Mauri, Susan E. Ross
Objective. To define the mechanisms of action of 2 novel drugs, cyclosporine and anti-tumor necrosis factor alpha (TNF alpha), in collagen-induced arthritis and to determine the effect of combination therapy.Methods. Type II collagen-immunized DBA/1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b5987a26dc0a7a2b200e42c0e41bb2
https://doi.org/10.1002/1529-0131(199810)41:10<1806::aid-art12>3.0.co
https://doi.org/10.1002/1529-0131(199810)41:10<1806::aid-art12>3.0.co
Autor:
D Cosgrove, C Wagner, M Blomley, C McClinton, A Steuer, J Gruber, Ravinder N. Maini, Peter C. Taylor, P Marsters
Objective To compare the impact of immediate and delayed introduction of anti–tumor necrosis factor therapy on inflammation and structural damage in methotrexate (MTX)–treated patients with early rheumatoid arthritis (RA). Methods Twenty-four pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a668260b957effedbcc6e1a348c6b44
https://ora.ox.ac.uk/objects/uuid:a937d904-522c-4435-8087-77db7532a4c1
https://ora.ox.ac.uk/objects/uuid:a937d904-522c-4435-8087-77db7532a4c1
Rheumatoid arthritis (RA) is well known to be a chronic autoimmune/inflammatory disease which leads to progressive joint damage and destruction. Less well known is the fact that in severe cases of RA, with extra-articular manifestations and multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ffab6e62ce013b43031a9fa09d1baf
https://doi.org/10.1007/bf00832003
https://doi.org/10.1007/bf00832003
Autor:
Lilia Marinova-Mutafchieva, K Funa, Nathan J. Zvaifler, Ravinder N. Maini, Richard O. Williams
Objective To determine the involvement of mesenchymal progenitor cells in the induction of collagen-induced arthritis (CIA). Methods DBA/1 mice were immunized with type II collagen in adjuvant or adjuvant alone, and the presence of mesenchymal cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba916ba76c8249b0efc23af890b3468
https://ora.ox.ac.uk/objects/uuid:d6e19d31-3dff-4e47-9f2a-2f9375466dbd
https://ora.ox.ac.uk/objects/uuid:d6e19d31-3dff-4e47-9f2a-2f9375466dbd
Autor:
Marc Feldmann, Martin R Turner, A M Kissonerghis, G Buchan, C Haworth, A Ziegler, Ravinder N. Maini, K Barrett, Fionula M. Brennan, David Chantry
Publikováno v:
Scopus-Elsevier
HLA class II expression is notable in rheumatoid arthritis. We have investigated the mechanism of HLA class II regulation in the joints and found local synthesis, as judged by mRNA levels to be high. The role of antigen presentation in maintaining cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b96e24e167dc9446908d59e4d764092
https://doi.org/10.3109/03009748809102951
https://doi.org/10.3109/03009748809102951
Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that many proinflammatory cytokines such as TNF alpha, IL-1, IL-6, GM-CSF, and chemokines such as IL-8 are abundant in all patients regardless of therapy. This is compensat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f747ff1cad0ea6f3bfba811705a5716a
https://doi.org/10.1146/annurev.immunol.14.1.397
https://doi.org/10.1146/annurev.immunol.14.1.397
Cytokines are important protein mediators of immunity, inflammation, cell proliferation, differentiation, fibrosis, etc. (Oppenheim and Saklatvala, 1993). As these are the major biological processes underlying autoimmunity, it is not surprising that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f619ff9f4626f9fc3d17948513d801e
https://doi.org/10.3109/08830189809084493
https://doi.org/10.3109/08830189809084493