Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Ravinder Kodela"'
Autor:
Niharika Nath, Mitali Chattopadhyay, Deborah B. Rodes, Anna Nazarenko, Ravinder Kodela, Khosrow Kashfi
Publikováno v:
Molecules, Vol 20, Iss 7, Pp 12481-12499 (2015)
Estrogen receptor negative (ER(−)) breast cancer is aggressive, responds poorly to current treatments and has a poor prognosis. The NF-κB signaling pathway is implicated in ER(−) tumorigenesis. Aspirin (ASA) is chemopreventive against ER(+) but
Externí odkaz:
https://doaj.org/article/75becab826b84b18a6eab4226d4bd0b3
Publikováno v:
Redox Biology, Vol 5, Iss , Pp 421- (2015)
Background: NOSH-aspirin, a novel hybrid that releases nitric oxide (NO) and hydrogen sulfide (H2S) was designed to overcome the potential side effects of aspirin. Aim: We compared the cell growth inhibitory properties of ortho-, meta-, and para-NOSH
Externí odkaz:
https://doaj.org/article/e2d7fdf7d7774c6594bd09d4b2f5620f
Publikováno v:
The FASEB Journal. 33
Autor:
Khosrow Kashfi, Niharika Nath, Gabriela Santiago, Thuy Tien C. Le, Ravinder Kodela, Mitali Chattopadhyay
Publikováno v:
Biochem Pharmacol
Pancreatic cancer has poor survival rates and largely ineffective therapies. Aspirin is the prototypical anti-cancer agent but its long-term use is associated with significant side effects. NOSH-aspirin belongs to a new class of anti-inflammatory age
Publikováno v:
Redox Biology
We recently reported the synthesis of NOSH-aspirin, a novel hybrid that releases both nitric oxide (NO) and hydrogen sulfide (H2S). In NOSH-aspirin, the two moieties that release NO and H2S are covalently linked at the 1, 2 positions of acetyl salicy
Publikováno v:
Redox Biology
Sulindac is chemopreventive and has utility in patients with familial adenomatous polyposis; however, side effects preclude its long-term use. NOSH-sulindac (AVT-18A) releases nitric oxide and hydrogen sulfide, was designed to be a safer alternative.
Publikováno v:
Glia. 61:1724-1734
Hydrogen sulfide (H2 S) and nitric oxide (NO) have been described as gasotransmitters. Anti-inflammatory activity in the central and peripheral nervous systems may be one of their functions. Previously we demonstrated that several SH(-) donors includ
Publikováno v:
Pharmacology Research & Perspectives. 4
Naproxen (NAP) is a potent nonsteroidal anti-inflammatory drug (NSAID) with a favorable cardiovascular profile. However, its long-term use may lead to serious gastrointestinal and renal side effects. NOSH- (nitric oxide and hydrogen sulfide) releasin
Autor:
Carlos A. Velázquez-Martínez, Daniel Boring, Ravinder Kodela, Khosrow Kashfi, Yosef M. Dastagirzada, Niharika Nath, Mitali Chattopadhyay
Publikováno v:
Biochemical Pharmacology. 83:715-722
Hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs (HS-NSAIDs) are an emerging novel class of compounds with significant anti-inflammatory properties. They consist of a traditional NSAID to which an H(2)S-releasing moiety is covalently
Autor:
Daniel Boring, Khosrow Kashfi, Niharika Nath, Mitali Chattopadhyay, Cherease R. Street, Ravinder Kodela, Carlos A. Velázquez-Martínez
Publikováno v:
Biochemical Pharmacology. 83:733-740
The balance between phase-I carcinogen-activating and phase-II detoxifying xenobiotic metabolizing enzymes is critical to determining an individual's risk for cancer. We evaluated the effect of Hydrogen sulfide-releasing aspirin (HS-ASA) on xenobioti