Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ravinder Atkar"'
Autor:
Rebecca L. McCarthy, Soha S. Tawfik, Ioannis Theocharopoulos, Ravinder Atkar, Bryan McDonald, Sasha Dhoat, Aaron Hughes, Bjorn R. Thomas, Edel A. O’Toole
Publikováno v:
Skin Health and Disease, Vol 4, Iss 3, Pp n/a-n/a (2024)
Abstract Background Atopic eczema is a common, chronic, inflammatory skin condition with considerable heterogeneity. South Asian people living in the UK frequently have low serum vitamin D3 (25(OH)D3), and those with atopic disease can present with s
Externí odkaz:
https://doaj.org/article/bbd84909b8044484bff134894e043519
Autor:
Christos Tziotzios, Christos Petridis, Nick Dand, Chrysanthi Ainali, Jake R. Saklatvala, Venu Pullabhatla, Alexandros Onoufriadis, Rashida Pramanik, David Baudry, Sang Hyuck Lee, Kristie Wood, Lu Liu, Seth Seegobin, Gregory A. Michelotti, Su M. Lwin, Evangelos A. A. Christou, Charles J. Curtis, Emanuele de Rinaldis, Alka Saxena, Susan Holmes, Matthew Harries, Ioulios Palamaras, Fiona Cunningham, Gregory Parkins, Manjit Kaur, Paul Farrant, Andrew McDonagh, Andrew Messenger, Jennifer Jones, Victoria Jolliffe, Iaisha Ali, Michael Ardern-Jones, Charles Mitchell, Nigel Burrows, Ravinder Atkar, Cedric Banfield, Anton Alexandroff, Caroline Champagne, Hywel L. Cooper, Sergio Vañó-Galván, Ana Maria Molina-Ruiz, Nerea Ormaechea Perez, Girish K. Patel, Abby Macbeth, Melanie Page, Alyson Bryden, Megan Mowbray, Shyamal Wahie, Keith Armstrong, Nicola Cooke, Mark Goodfield, Irene Man, David de Berker, Giles Dunnill, Anita Takwale, Archana Rao, Tee-Wei Siah, Rodney Sinclair, Martin S. Wade, Ncoza C. Dlova, Jane Setterfield, Fiona Lewis, Kapil Bhargava, Niall Kirkpatrick, Xavier Estivill, Catherine M. Stefanato, Carsten Flohr, Timothy Spector, Fiona M. Watt, Catherine H. Smith, Jonathan N. Barker, David A. Fenton, Michael A. Simpson, John A. McGrath
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Frontal fibrosing alopecia (FFA) features lichenoid cutaneous inflammation and scarring hair loss. Here, Tziotzios et al. identify four genetic loci associated with FFA by GWAS followed by Bayesian fine-mapping, co-localisation and HLA imputation whi
Externí odkaz:
https://doaj.org/article/2a42af5d272646528b4002af71d71088
Autor:
Bjorn R Thomas, Xiang Li Tan, Stefan Van Duijvenboden, Sarah C Hogan, Aaron J Hughes, Soha S Tawfik, Sasha Dhoat, Ravinder Atkar, Elizabeth J Robinson, Syedia R Rahman, Samiha Rahman, Rehana A Ahmed, Rubina Begum, Habiba Khanam, Emma L Bourne, Eva L Wozniak, Charles A Mein, David P Kelsell, Edel A O’Toole
Publikováno v:
British Journal of Dermatology. 188:785-792
Background Hyperlinear palms are described as a feature of loss-of-function (LoF) variants in filaggrin (FLG). Objectives To explore the phenotype of participants (age < 31 years) with atopic eczema of Bangladeshi ancestry from East London and invest
Autor:
Graham W. Neill, Mike P. Philpott, Kenneth J. Linton, David P. Kelsell, Ravinder Atkar, Muhammad S. Pirzado, Catherine A. Harwood, Dimalee S. Herath, Joanne L. Selway, Allon Hazan, Muhammad M. Rahman
[A] Various exon 24 clones generated from heterogeneous populations of PTCH1 suppressed NEB1 cells show reduced PTCH1 and increased GLI1 mRNA expression. [B] Both human and mouse SMO protein sequences contain predicted nuclear and nucleolar localisat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b044d18f7b24f0f78ee05c491128fa
https://doi.org/10.1158/0008-5472.22420313
https://doi.org/10.1158/0008-5472.22420313
Autor:
Graham W. Neill, Mike P. Philpott, Kenneth J. Linton, David P. Kelsell, Ravinder Atkar, Muhammad S. Pirzado, Catherine A. Harwood, Dimalee S. Herath, Joanne L. Selway, Allon Hazan, Muhammad M. Rahman
Small-molecule inhibitors of the Hedgehog (HH) pathway receptor Smoothened (SMO) have been effective in treating some patients with basal cell carcinoma (BCC), where the HH pathway is often activated, but many patients respond poorly. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843ce48a60ee1307e6d00253da450b72
https://doi.org/10.1158/0008-5472.c.6510620
https://doi.org/10.1158/0008-5472.c.6510620
Autor:
Graham W. Neill, Mike P. Philpott, Kenneth J. Linton, David P. Kelsell, Ravinder Atkar, Muhammad S. Pirzado, Catherine A. Harwood, Dimalee S. Herath, Joanne L. Selway, Allon Hazan, Muhammad M. Rahman
Single supplementary figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e12af613332ec6db7d9da84c5eff4eb
https://doi.org/10.1158/0008-5472.22420316
https://doi.org/10.1158/0008-5472.22420316
Autor:
Catherine A. Harwood, John C. Bladen, Muhammad M Rahman, Ravinder Atkar, Graham W. Neill, Dimalee S Herath, Michael P. Philpott, Muhammad S Pirzado
Publikováno v:
Carcinogenesis. 42:975-983
Basal cell carcinoma (BCC) is associated with aberrant Hedgehog (HH) signalling through mutational inactivation of PTCH1; however, there is conflicting data regarding MEK/ERK signalling in BCC and the signalling pathway interactions in these carcinom
Autor:
Paul Farrant, Mark Goodfield, Catherine H. Smith, V. Jolliffe, Gregory Parkins, Caroline Champagne, Lu Liu, Nigel Burrows, A. S. Bryden, Kristie Wood, Anton B. Alexandroff, Irene Man, Alka Saxena, Su M. Lwin, Iaisha Ali, Catherine M. Stefanato, Kapil Bhargava, Sang Hyuck Lee, Melanie Page, Xavier Estivill, Tim D. Spector, Carsten Flohr, Susan Holmes, David de Berker, A. E. Macbeth, Ncoza C. Dlova, David Baudry, Jake Saklatvala, Nerea Ormaechea Perez, Archana Rao, David A. Fenton, Martin S Wade, Cedric Charles Banfield, Jennifer Jones, Evangelos A A Christou, Ravinder Atkar, Gregory A Michelotti, Sergio Vano-Galvan, Seth D. Seegobin, Jane Setterfield, Jonathan Barker, Chrysanthi Ainali, Christos Tziotzios, Charles Curtis, Rashida Pramanik, Matthew Harries, Girish K Patel, Niall Kirkpatrick, Venu Pullabhatla, Fiona Cunningham, Nick Dand, Hywel L Cooper, Rodney Sinclair, Keith Armstrong, Emanuele de Rinaldis, Andrew J. G. McDonagh, M R Kaur, Fiona Lewis, Michael A. Simpson, John A. McGrath, Charles E. Mitchell, Nicola Cooke, Fiona M. Watt, Alexandros Onoufriadis, Michael R. Ardern-Jones, Tee-Wei Siah, Ioulios Palamaras, Ana María Molina-Ruiz, Megan Mowbray, A. Takwale, Andrew G. Messenger, Giles Dunnill, Christos Petridis, Shyamal Wahie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Tziotzios, C, Petridis, C, Dand, N, Ainali, C, Saklatvala, J R, Pullabhatla, V, Onoufriadis, A, Pramanik, R, Baudry, D, Lee, S H, Wood, K, Liu, L, Seegobin, S, Michelotti, G A, Lwin, S M, Christou, E A A, Curtis, C J, de Rinaldis, E, Saxena, A, Holmes, S, Harries, M, Palamaras, I, Cunningham, F, Parkins, G, Kaur, M, Farrant, P, McDonagh, A, Messenger, A, Jones, J, Jolliffe, V, Ali, I, Ardern-Jones, M, Mitchell, C, Burrows, N, Atkar, R, Banfield, C, Alexandroff, A, Champagne, C, Cooper, H L, Vañó-Galván, S, Molina-Ruiz, A M, Perez, N O, Patel, G K, Macbeth, A, Page, M, Bryden, A, Mowbray, M, Wahie, S, Armstrong, K, Cooke, N, Goodfield, M, Man, I, de Berker, D, Dunnill, G, Takwale, A, Rao, A, Siah, T-W, Sinclair, R, Wade, M S, Dlova, N C, Setterfield, J, Lewis, F, Bhargava, K, Kirkpatrick, N, Estivill, X, Stefanato, C M, Flohr, C, Spector, T, Watt, F M, Smith, C H, Barker, J N, Fenton, D A, Simpson, M A & McGrath, J A 2019, ' Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 ', Nature Communications, vol. 10, no. 1, 1150 . https://doi.org/10.1038/s41467-019-09117-w
Tziotzios, C, Petridis, C, Dand, N, Ainali, C, Saklatvala, J R, Pullabhatla, V, Onoufriadis, A, Pramanik, R, Baudry, D, Lee, S H, Wood, K, Liu, L, Seegobin, S, Michelotti, G A, Lwin, S M, Christou, E A A, Curtis, C J, de Rinaldis, E, Saxena, A, Holmes, S, Harries, M, Palamaras, I, Cunningham, F, Parkins, G, Kaur, M, Farrant, P, McDonagh, A, Messenger, A, Jones, J, Jolliffe, V, Ali, I, Ardern-Jones, M, Mitchell, C, Burrows, N, Atkar, R, Banfield, C, Alexandroff, A, Champagne, C, Cooper, H L, Vañó-Galván, S, Molina-Ruiz, A M, Perez, N O, Patel, G K, Macbeth, A, Page, M, Bryden, A, Mowbray, M, Wahie, S, Armstrong, K, Cooke, N, Goodfield, M, Man, I, de Berker, D, Dunnill, G, Takwale, A, Rao, A, Siah, T W, Sinclair, R, Wade, M S, Dlova, N C, Setterfield, J, Lewis, F, Bhargava, K, Kirkpatrick, N, Estivill, X, Stefanato, C M, Flohr, C, Spector, T, Watt, F M, Smith, C H, Barker, J N, Fenton, D A, Simpson, M A & McGrath, J A 2019, ' Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 ', Nature Communications, vol. 10, no. 1, 1150 . https://doi.org/10.1038/s41467-019-09117-w
Nature Communications
Tziotzios, C, Petridis, C, Dand, N, Ainali, C, Saklatvala, J R, Pullabhatla, V, Onoufriadis, A, Pramanik, R, Baudry, D, Lee, S H, Wood, K, Liu, L, Seegobin, S, Michelotti, G A, Lwin, S M, Christou, E A A, Curtis, C J, de Rinaldis, E, Saxena, A, Holmes, S, Harries, M, Palamaras, I, Cunningham, F, Parkins, G, Kaur, M, Farrant, P, McDonagh, A, Messenger, A, Jones, J, Jolliffe, V, Ali, I, Ardern-Jones, M, Mitchell, C, Burrows, N, Atkar, R, Banfield, C, Alexandroff, A, Champagne, C, Cooper, H L, Vañó-Galván, S, Molina-Ruiz, A M, Perez, N O, Patel, G K, Macbeth, A, Page, M, Bryden, A, Mowbray, M, Wahie, S, Armstrong, K, Cooke, N, Goodfield, M, Man, I, de Berker, D, Dunnill, G, Takwale, A, Rao, A, Siah, T-W, Sinclair, R, Wade, M S, Dlova, N C, Setterfield, J, Lewis, F, Bhargava, K, Kirkpatrick, N, Estivill, X, Stefanato, C M, Flohr, C, Spector, T, Watt, F M, Smith, C H, Barker, J N, Fenton, D A, Simpson, M A & McGrath, J A 2019, ' Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 ', Nature Communications, vol. 10, no. 1, 1150 . https://doi.org/10.1038/s41467-019-09117-w
Tziotzios, C, Petridis, C, Dand, N, Ainali, C, Saklatvala, J R, Pullabhatla, V, Onoufriadis, A, Pramanik, R, Baudry, D, Lee, S H, Wood, K, Liu, L, Seegobin, S, Michelotti, G A, Lwin, S M, Christou, E A A, Curtis, C J, de Rinaldis, E, Saxena, A, Holmes, S, Harries, M, Palamaras, I, Cunningham, F, Parkins, G, Kaur, M, Farrant, P, McDonagh, A, Messenger, A, Jones, J, Jolliffe, V, Ali, I, Ardern-Jones, M, Mitchell, C, Burrows, N, Atkar, R, Banfield, C, Alexandroff, A, Champagne, C, Cooper, H L, Vañó-Galván, S, Molina-Ruiz, A M, Perez, N O, Patel, G K, Macbeth, A, Page, M, Bryden, A, Mowbray, M, Wahie, S, Armstrong, K, Cooke, N, Goodfield, M, Man, I, de Berker, D, Dunnill, G, Takwale, A, Rao, A, Siah, T W, Sinclair, R, Wade, M S, Dlova, N C, Setterfield, J, Lewis, F, Bhargava, K, Kirkpatrick, N, Estivill, X, Stefanato, C M, Flohr, C, Spector, T, Watt, F M, Smith, C H, Barker, J N, Fenton, D A, Simpson, M A & McGrath, J A 2019, ' Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 ', Nature Communications, vol. 10, no. 1, 1150 . https://doi.org/10.1038/s41467-019-09117-w
Frontal fibrosing alopecia (FFA) is a recently described inflammatory and scarring type of hair loss affecting almost exclusively women. Despite a dramatic recent increase in incidence the aetiopathogenesis of FFA remains unknown. We undertake genome
Autor:
Graham W. Neill, Catherine A. Harwood, Ravinder Atkar, Michael P. Philpott, Allon Hazan, Dimalee S Herath, Joanne L. Selway, Kenneth J. Linton, Muhammad M Rahman, David P. Kelsell, Muhammad S Pirzado
Publikováno v:
Cancer Research. 78:2577-2588
Small-molecule inhibitors of the Hedgehog (HH) pathway receptor Smoothened (SMO) have been effective in treating some patients with basal cell carcinoma (BCC), where the HH pathway is often activated, but many patients respond poorly. In this study,
Autor:
Eleonora Seelig, Emma L Arbon, Marcin L. Pekalski, James Howlett, Linda S. Wicker, Adrian Mander, Neil Walker, Mark L. Evans, Linsey Porter, James Heywood, Simon Bond, Ravinder Atkar, Ed Rytina, John A. Todd, Katerina Anselmiova, Lucy Truman, Jane Kennet, Frank Waldron-Lynch
BACKGROUND. Type 1 diabetes (T1D) results from loss of immune regulation, leading to the development of autoimmunity to pancreatic β cells, involving autoreactive T effector cells (Teffs). Tregs, which prevent autoimmunity, require IL-2 for maintena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660273a0ea5d1eeb85c57d85161b7002
https://www.repository.cam.ac.uk/handle/1810/285685
https://www.repository.cam.ac.uk/handle/1810/285685