Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ravinandan Venkatasubramanian"'
Autor:
Kevin O. Murray, Sophia A. Mahoney, Ravinandan Venkatasubramanian, Douglas R. Seals, Zachary S. Clayton
Publikováno v:
Experimental Gerontology, Vol 173, Iss , Pp 112105- (2023)
Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is characterized by impaired vascular endothelial function and stiffening of the
Externí odkaz:
https://doaj.org/article/00a14a75deac44d691207513daf2dde3
Autor:
Abigail G. Longtine, Ravinandan Venkatasubramanian, Melanie C. Zigler, Alexandra J. Lindquist, Sophia A. Mahoney, Nathan T. Greenberg, Nicholas S. VanDongen, Katelyn R. Ludwig, Kerrie L. Moreau, Douglas R. Seals, Zachary S. Clayton
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 324:H893-H904
Our study demonstrates that with aging, female C57BL/6N mice exhibit higher in vivo aortic stiffness, reduced modulus of elasticity, aortic wall structural and extracellular matrix remodeling, and elevations in systemic inflammation. These changes ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06070df51d925cdbe344930d42918d6c
https://doi.org/10.1152/ajpheart.00120.2023
https://doi.org/10.1152/ajpheart.00120.2023
Autor:
Abigail Longtine, Ravinandan Venkatasubramanian, Melanie Zigler, Alexandra Lindquist, Sophia Mahoney, Nathan Greenberg, Nicholas VanDongen, Katelyn Ludwig, Kerrie Moreau, Douglas Seals, Zachary Clayton
Publikováno v:
Physiology. 38
The aorta stiffens with aging in both men and women and predicts cardiovascular mortality. Stiffening occurs largely due to aortic wall structural remodeling induced, in part, by chronic low-grade inflammation. Use of animal models in biomedical rese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96f4daa5e309ecc8b09607685cc96ab6
https://doi.org/10.1152/physiol.2023.38.s1.5727898
https://doi.org/10.1152/physiol.2023.38.s1.5727898
Autor:
Ravinandan Venkatasubramanian, Sophia Mahoney, Grace Maurer, Mary Darrah, Katelyn Ludwig, Nicholas VanDongen, Matthew Rossman, Vienna Brunt, Judith Campisi, Douglas Seals, Zachary Clayton
Publikováno v:
Physiology. 38
Doxorubicin (DOXO) chemotherapy induces vascular dysfunction (aortic stiffening and endothelial dysfunction). Cellular senescence and the related increase in oxidative stress, notably mitochondrial reactive oxygen species (mtROS), are implicated in D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9c9c23b245c492b47948bcb507450a3
https://doi.org/10.1152/physiol.2023.38.s1.5733334
https://doi.org/10.1152/physiol.2023.38.s1.5733334
Autor:
Sophia Mahoney, Serban Ciotlos, Mary Darrah, Ravinandan Venkatasubramanian, Matthew Rossman, Judith Campisi, Douglas Seals, Simon Melov, Zachary Clayton
Publikováno v:
Physiology. 38
Aortic stiffnessincreases with aging and is an independent risk factor for the development of cardiovascular diseases. Cellular senescence, a state of cell cycle arrest that accumulates in arteries with aging, contributes to age-related aortic stiffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a46dd8200005b33d7d195efc01e0cd
https://doi.org/10.1152/physiol.2023.38.s1.5711505
https://doi.org/10.1152/physiol.2023.38.s1.5711505
Autor:
Mary Darrah, Ravinandan Venkatasubramanian, Sophia Mahoney, Katelyn Ludwig, David Hutton, Vienna Brunt, Matthew Rossman, Judith Campisi, Douglas Seals, Zachary Clayton
Publikováno v:
Physiology. 38
Introduction: The common chemotherapeutic agent doxorubicin (DOXO) mediates large elastic artery (aorta) stiffness in part via chronic low-grade inflammation. Cellular senescence is an established source of inflammation, largely as a result of the se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1d314d61e763034aaf0e4f35276ad1e
https://doi.org/10.1152/physiol.2023.38.s1.5733994
https://doi.org/10.1152/physiol.2023.38.s1.5733994
Publikováno v:
The Journal of Physiology. 600:1821-1823
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48eb9afef00d0a7a3284355c9649e48b
https://doi.org/10.1113/jp282581
https://doi.org/10.1113/jp282581
Autor:
Ravinandan Venkatasubramanian, Sophia A. Mahoney, Matthew J. Rossman, David A. Hutton, Vienna E. Brunt, Nicholas S. VanDongen, Abigail G. Casso, Nathan T. Greenberg, Yara B. Quiros, Simon Melov, Judith Campisi, Douglas R. Seals, Zachary S. Clayton
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a06107cfae0795ccbbf2bfa7995751f9
https://doi.org/10.1096/fasebj.2022.36.s1.r2053
https://doi.org/10.1096/fasebj.2022.36.s1.r2053