Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Ravinandan Venkatasubramanian"'
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Akademický článek
Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions
Autor: Kevin O. Murray, Sophia A. Mahoney, Ravinandan Venkatasubramanian, Douglas R. Seals, Zachary S. Clayton
Publikováno v: Experimental Gerontology, Vol 173, Iss , Pp 112105- (2023)
Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is characterized by impaired vascular endothelial function and stiffening of the
Externí odkaz: https://doaj.org/article/00a14a75deac44d691207513daf2dde3
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2
Female C57BL/6N mice are a viable model of aortic aging in women
Autor: Abigail G. Longtine, Ravinandan Venkatasubramanian, Melanie C. Zigler, Alexandra J. Lindquist, Sophia A. Mahoney, Nathan T. Greenberg, Nicholas S. VanDongen, Katelyn R. Ludwig, Kerrie L. Moreau, Douglas R. Seals, Zachary S. Clayton
Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 324:H893-H904
Our study demonstrates that with aging, female C57BL/6N mice exhibit higher in vivo aortic stiffness, reduced modulus of elasticity, aortic wall structural and extracellular matrix remodeling, and elevations in systemic inflammation. These changes ar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06070df51d925cdbe344930d42918d6c
https://doi.org/10.1152/ajpheart.00120.2023
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3
Female C57Bl/6N mice are a viable model of human aortic aging: Aortic stiffness and structure and systemic inflammation
Autor: Abigail Longtine, Ravinandan Venkatasubramanian, Melanie Zigler, Alexandra Lindquist, Sophia Mahoney, Nathan Greenberg, Nicholas VanDongen, Katelyn Ludwig, Kerrie Moreau, Douglas Seals, Zachary Clayton
Publikováno v: Physiology. 38
The aorta stiffens with aging in both men and women and predicts cardiovascular mortality. Stiffening occurs largely due to aortic wall structural remodeling induced, in part, by chronic low-grade inflammation. Use of animal models in biomedical rese
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96f4daa5e309ecc8b09607685cc96ab6
https://doi.org/10.1152/physiol.2023.38.s1.5727898
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4
Senolytic administration following doxorubicin chemotherapy prevents large elastic artery stiffening and endothelial dysfunction
Autor: Ravinandan Venkatasubramanian, Sophia Mahoney, Grace Maurer, Mary Darrah, Katelyn Ludwig, Nicholas VanDongen, Matthew Rossman, Vienna Brunt, Judith Campisi, Douglas Seals, Zachary Clayton
Publikováno v: Physiology. 38
Doxorubicin (DOXO) chemotherapy induces vascular dysfunction (aortic stiffening and endothelial dysfunction). Cellular senescence and the related increase in oxidative stress, notably mitochondrial reactive oxygen species (mtROS), are implicated in D
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9c9c23b245c492b47948bcb507450a3
https://doi.org/10.1152/physiol.2023.38.s1.5733334
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5
25-Hydroxycholesterol reduces aortic cellular senescence and stiffness in old mice
Autor: Sophia Mahoney, Serban Ciotlos, Mary Darrah, Ravinandan Venkatasubramanian, Matthew Rossman, Judith Campisi, Douglas Seals, Simon Melov, Zachary Clayton
Publikováno v: Physiology. 38
Aortic stiffnessincreases with aging and is an independent risk factor for the development of cardiovascular diseases. Cellular senescence, a state of cell cycle arrest that accumulates in arteries with aging, contributes to age-related aortic stiffe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8a46dd8200005b33d7d195efc01e0cd
https://doi.org/10.1152/physiol.2023.38.s1.5711505
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