Spinal Cord Molecular and Cellular Changes Induced by Adenoviral Vector- and Cell-Mediated Triple Gene Therapy after Severe Contusion

Autor: Andrei A. Izmailov, Tatyana V. Povysheva, Farid V. Bashirov, Mikhail E. Sokolov, Filip O. Fadeev, Ravil R. Garifulin, Boris S. Naroditsky, Denis Y. Logunov, Ilnur I. Salafutdinov, Yuri A. Chelyshev, Rustem R. Islamov, Igor A. Lavrov

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

The gene therapy has been successful in treatment of spinal cord injury (SCI) in several animal models, although it still remains unavailable for clinical practice. Surprisingly, regardless the fact that multiple reports showed motor recovery with ge

Externí odkaz: https://doaj.org/article/c6e108b6313c43e9966140508bbbbe16

Combined Supra- and Sub-Lesional Epidural Electrical Stimulation for Restoration of the Motor Functions after Spinal Cord Injury in Mini Pigs

Autor: Vage Markosyan, Mikhail Evgenyevich Sokolov, Andrei Izmailov, Anton Eremeev, Julia Kalistratova, Anastasiia Khalitova, Farid V. Bashirov, Igor Lavrov, Roman Shevchenko, Filip O. Fadeev, Ravil R. Garifulin, Rustem R. Islamov

Publikováno v: Brain Sciences
Volume 10
Issue 10
Brain Sciences, Vol 10, Iss 744, p 744 (2020)

This study evaluates the effect of combined epidural electrical stimulation (EES) applied above (C5) and below (L2) the spinal cord injury (SCI) at T8&ndash
9 combined with motor training on the restoration of sensorimotor function in mini pigs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d8d5939b88d2eca40f6ab853ecaaaf

Biosafety Evaluation of a Chimeric Adenoviral Vector in Mini-Pigs: Insights into Immune Tolerance and Gene Therapy Potential.

Autor: Izmailov A; Department of Histology, Cytology and Embryology, Kazan State Medical University, 420012 Kazan, Russia., Minyazeva I; Department of Histology, Cytology and Embryology, Kazan State Medical University, 420012 Kazan, Russia., Markosyan V; Department of Topographic Anatomy and Operative Surgery, Kazan State Medical University, 420012 Kazan, Russia., Safiullov Z; Department of Anatomy, Kazan State Medical University, 420012 Kazan, Russia., Gazizov I; Department of Anatomy, Kazan State Medical University, 420012 Kazan, Russia., Salafutdinov I; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia., Markelova M; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia., Garifulin R; Department of Histology, Cytology and Embryology, Kazan State Medical University, 420012 Kazan, Russia., Shmarov M; The National Research Center for Epidemiology and Microbiology Named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Logunov D; The National Research Center for Epidemiology and Microbiology Named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Islamov R; Department of Histology, Cytology and Embryology, Kazan State Medical University, 420012 Kazan, Russia., Pospelov V; LLC 'Impulse of Life', Marshala Biryuzova Str., 32, 123060 Moscow, Russia.

Publikováno v: Biomedicines [Biomedicines] 2024 Nov 09; Vol. 12 (11). Date of Electronic Publication: 2024 Nov 09.

Autologous Genetically Enriched Leucoconcentrate in the Preventive and Acute Phases of Stroke Treatment in a Mini-Pig Model.

Autor: Safiullov Z; The Department of Histology, Cytology and Embryology, Kazan State Medical University, 420012 Kazan, Russia., Izmailov A; The Department of Histology, Cytology and Embryology, Kazan State Medical University, 420012 Kazan, Russia., Sokolov M; The Department of Histology, Cytology and Embryology, Kazan State Medical University, 420012 Kazan, Russia., Markosyan V; The Department of Histology, Cytology and Embryology, Kazan State Medical University, 420012 Kazan, Russia., Kundakchan G; The Department of Histology, Cytology and Embryology, Kazan State Medical University, 420012 Kazan, Russia., Garifulin R; The Department of Histology, Cytology and Embryology, Kazan State Medical University, 420012 Kazan, Russia., Shmarov M; The National Research Center for Epidemiology and Microbiology Named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Naroditsky B; The National Research Center for Epidemiology and Microbiology Named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Logunov D; The National Research Center for Epidemiology and Microbiology Named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Islamov R; The Department of Histology, Cytology and Embryology, Kazan State Medical University, 420012 Kazan, Russia.

Publikováno v: Pharmaceutics [Pharmaceutics] 2022 Oct 17; Vol. 14 (10). Date of Electronic Publication: 2022 Oct 17.

Combined Supra- and Sub-Lesional Epidural Electrical Stimulation for Restoration of the Motor Functions after Spinal Cord Injury in Mini Pigs.

Autor: Fadeev F; Department of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia., Eremeev A; Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia., Bashirov F; Department of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia., Shevchenko R; Department of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia., Izmailov A; Department of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia., Markosyan V; Department of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia., Sokolov M; Department of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia., Kalistratova J; Department of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia., Khalitova A; Department of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia., Garifulin R; Department of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia., Islamov R; Department of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia., Lavrov I; Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.; Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.; Department of Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Publikováno v: Brain sciences [Brain Sci] 2020 Oct 16; Vol. 10 (10). Date of Electronic Publication: 2020 Oct 16.