Výsledky vyhledávání - "Ravikumar Peri"

Development of an Improved IP1 Assay for the Characterization of 5-HT2C Receptor Ligands

Autor: Mark H. Pausch, John Dunlop, Stanley Nawoschik, Jean Y. Zhang, Dianne Kowal, Ravikumar Peri

Publikováno v: ASSAY and Drug Development Technologies. 8:106-113

The 5-hydroxytryptamine 2C (5-HT(2C)) receptor is a member of the serotonin 5-HT(2) subfamily of G-protein-coupled receptors signaling predominantly via the phospholipase C (PLC) pathway. Stimulation of phosphoinositide (PI) hydrolysis upon 5-HT(2C)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948dbefafd3cc39a7dead631bc6979ab
https://doi.org/10.1089/adt.2009.0205

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Regulation of L-type Calcium Channels in Pituitary GH4C1 Cells by Depolarization

Autor: Ravikumar Peri, David J. Triggle, Satpal Singh

Publikováno v: Journal of Biological Chemistry. 276:31667-31673

The neurosecretory anterior pituitary GH(4)C(1) cells exhibit the high voltage-activated dihydropyridine-sensitive L-type and the low voltage-activated T-type calcium currents. The activity of L-type calcium channels is tightly coupled to secretion o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b07d013dfb3415ab948075f74f21fb
https://doi.org/10.1074/jbc.m102613200

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Synthesis and binding properties of 2H-1-benzopyran-2 one fluorophore-linked calcium channel antagonist nifedipine (1,4-dihydropyridine) analogs

Autor: David J. Triggle, Seetharamaiyer Padmanabhan, Ravikumar Peri, A. Rutledge

Publikováno v: Journal of Heterocyclic Chemistry. 34:301-304

Nifedipine analogs I, II and III with the 2H-1-benzopyran-2-one (coumarin) fluorophore linked at the 2, 2 and 6 and 4 positions of the dihydropyridine ring were synthesized by the modified Hantzch condensation procedures. Attempts to synthesize dihyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb4692bf9b482d4e0523d3d0df55d070
https://doi.org/10.1002/jhet.5570340146

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Functional screening of α7 nicotinic receptor ligands

Autor: John Dunlop, Georg C. Terstappen, Mark R. Bowlby, Ravikumar Peri

Publikováno v: Expert opinion on drug discovery. 3(6)

Background: The α7 nicotinic acetylcholine receptor, a ligand-gated ion channel, is an attractive drug discovery target in schizophrenia and Alzheimer's disease. Objective: We have evaluated the various approaches to discovering ligands targeting th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54eda9b5ed6749e34bbe414e0ee4daca
https://pubmed.ncbi.nlm.nih.gov/23506144

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Formation of Chromenes and Coumarin Derivatives From Salicylaldehydes and 2-Pentenedioate: Facile Route to 3-Formylcoumarins

Autor: David J. Triggle, Seetharamaiyer Padmanabhan, Ravikumar Peri

Publikováno v: Synthetic Communications. 26:827-831

Condensation of salicylaldehydes with diethyl 2-pentenedioate under the Knoevenagel conditions afforded either coumarin-3-acrylates or 2H-chromenedicarboxylate derivatives depending on the substituents on the aryl nucleus. Osmium tetroxide catalyzed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f1c07ccd73a3f8478241ccead26a13
https://doi.org/10.1080/00397919608086759

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Screening technologies for ion channel drug discovery

Autor: Georg C. Terstappen, John Dunlop, Ravikumar Peri, Renza Roncarati

Publikováno v: Future medicinal chemistry. 2(5)

For every movement, heartbeat and thought, ion channels need to open and close. It is therefore not surprising that their malfunctioning leads to serious diseases. Currently, only approximately 10% of drugs, with a market value in excess of US$10 bil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d507076c6fa6faac711447fc2df26c4
https://pubmed.ncbi.nlm.nih.gov/21426196

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