Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection

Autor: Simon J. L. Petitjean, Wenzhang Chen, Melanie Koehler, Ravikumar Jimmidi, Jinsung Yang, Danahe Mohammed, Blinera Juniku, Megan L. Stanifer, Steeve Boulant, Stéphane P. Vincent, David Alsteens

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Cell surface attachment factors, such as glycans, play an important role in viral infection. Here, Petitjean et al. show that SARS-CoV-2 specifically binds to 9-Oacetylated sialic acid and have designed novel inhibitors based on multivalent derivativ

Externí odkaz: https://doaj.org/article/ba3cf805c0e646fda33f22eb5939f940

Author Correction: Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection

Autor: Simon J. L. Petitjean, Wenzhang Chen, Melanie Koehler, Ravikumar Jimmidi, Jinsung Yang, Danahe Mohammed, Blinera Juniku, Megan L. Stanifer, Steeve Boulant, Stéphane P. Vincent, David Alsteens

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)

Externí odkaz: https://doaj.org/article/797c94b0be4841bf808c4aafdf4c0edd

Pillar[5]arene-Based Polycationic Glyco[2]rotaxanes Designed as

Autor: Tharwat, Mohy El Dine, Ravikumar, Jimmidi, Andrei, Diaconu, Maude, Fransolet, Carine, Michiels, Julien, De Winter, Emilie, Gillon, Anne, Imberty, Tom, Coenye, Stéphane P, Vincent

Publikováno v: Journal of medicinal chemistry. 64(19)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfec606eb189f9fb4abb5dd64fb55d2e
https://pubmed.ncbi.nlm.nih.gov/34542288

DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M pro inhibitors

Autor: Ravikumar Jimmidi, Kurt M. Bohren, Jeroen Pollet, Xuan Qin, Shannon E. Ronca, Timothy Palzkill, Shuo Lu, Zhifeng Yu, Damian W. Young, Srinivas Chamakuri, Zhi Tan, Ying-Chu Chen, Melek N. Ucisik, Feng Li, John C. Faver, J. Li, Stephen Palmer, Kiran L. Sharma, Martin M. Matzuk, Banumathi Sankaran, Huang-Chi Du, Leroy Versteeg, Pranavanand Nyshadham

Publikováno v: Proceedings of the National Academy of Sciences. 118

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4 million humans globally, but there is no bona fide Food and Drug Administration-approved drug-like molecule to impede the COVID-19 pandemic. The sluggish pace of trad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a995856c9d6262ef493039a76779d55a
https://doi.org/10.1073/pnas.2111172118

Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus

Autor: Xavier De Bolle, Arnaud Machelart, Katy Poncin, Eric Muraille, Emanuele G. Biondi, Nayla Francis, Agnès Roba, Kevin Willemart, Nicolas Zeippen, Georges Potemberg, Antonella Fioravanti, Stéphane P. Vincent, Ravikumar Jimmidi

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-12516-8⟩
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-12516-8⟩
Poncin, K, Roba, A, Jimmidi, R, Potemberg, G, Fioravanti, A, Francis, N, Willemart, K, Zeippen, N, Machelart, A, Biondi, E G, Muraille, E, Vincent, S P & De Bolle, X 2019, ' Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus ', Nature Communications, vol. 10, no. 1, 4847, pp. 4847 . https://doi.org/10.1038/s41467-019-12516-8
Nature communications, 10 (1
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

It is assumed that intracellular pathogenic bacteria have to cope with DNA alkylating stress within host cells. Here we use single-cell reporter systems to show that the pathogen Brucella abortus does encounter alkylating stress during the first hour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1d24f7e59a59df9acf427e3b9dd9bd
https://biblio.vub.ac.be/vubir/occurrence-and-repair-of-alkylating-stress-in-the-intracellular-pathogen-brucella-abortus(32eb28a2-69fe-4808-870b-f7c0710f221e).html