Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ravikanth Metlapally"'
Autor:
Ravikanth Metlapally, Pedro Gonzalez, Felicia A Hawthorne, Khanh-Nhat Tran-Viet, Christine F Wildsoet, Terri L Young
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78984 (2013)
INTRODUCTION:In human eyes, ocular enlargement/growth reflects active extracellular matrix remodeling of the outer scleral shell. Micro-RNAs are small non-coding RNAs that regulate gene expression by base pairing with target sequences. They serve as
Externí odkaz:
https://doaj.org/article/baeeb739aee74c25a2b6ad834949a8b6
Publikováno v:
Current eye research, vol 42, iss 6
PurposeThe ocular dimensional changes in myopia reflect increased scleral remodeling, and in high myopia, loss of scleral integrity leads to biomechanical weakening and continued scleral creep. As integrins, a type of cell surface receptors, have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21fdb5f8f68cd2b87dbf2922283f32ed
https://pubmed.ncbi.nlm.nih.gov/28094579
https://pubmed.ncbi.nlm.nih.gov/28094579
Autor:
Ravikanth Metlapally, Elizabeth St.Germain, Terri L. Young, Sheng Feng, Minyue Wang, Felicia Hawthorne, Xiaoyan Luo
Publikováno v:
Experimental Eye Research. 116:265-278
To study growth and development of ocular tissues, gene expression patterns in normal human fetal versus adult eyes were compared. Human retina/retinal pigment epithelium, choroid, sclera, optic nerve* and cornea* tissues were dissected from fetal (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7ac4b3caa4bfdf11352eac7c5830e8
https://doi.org/10.1016/j.exer.2013.08.009
https://doi.org/10.1016/j.exer.2013.08.009
Autor:
Sebastian Maurer-Stroh, Steve Rozen, Terri L. Young, Candice Ho, Caldwell Powell, Khanh-Nhat Tran-Viet, Seang-Mei Saw, Tammy L. Yanovitch, Thomas Klemm, Georg Schneider, Vincent Soler, Ravikanth Metlapally, Liang Goh, Veluchamy A. Barathi, Vachiranee Limviphuvadh, Yi-Ju Li, Erica B. Nading
Publikováno v:
The American Journal of Human Genetics. 92:820-826
Myopia, or near-sightedness, is an ocular refractive error of unfocused image quality in front of the retinal plane. Individuals with high-grade myopia (dioptric power greater than −6.00) are predisposed to ocular morbidities such as glaucoma, reti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bab3aab60d262e549367c345701a19
https://doi.org/10.1016/j.ajhg.2013.04.005
https://doi.org/10.1016/j.ajhg.2013.04.005
Autor:
Jacob G. Light, Ravikanth Metlapally, Christopher C. Tan, Han na Park, Christine F. Wildsoet, Kevin K. Wang, Ranjay Chakraborty, Machelle T. Pardue
Publikováno v:
Investigative ophthalmology & visual science, vol 57, iss 14
Metlapally, R; Park, HN; Chakraborty, R; Wang, KK; Tan, CC; Light, JG; et al.(2016). Genome-wide scleral micro-and messenger-RNA regulation during myopia development in the mouse. Investigative Ophthalmology and Visual Science, 57(14), 6089-6097. doi: 10.1167/iovs.16-19563. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/56g903dv
Investigative Ophthalmology & Visual Science
Metlapally, R; Park, HN; Chakraborty, R; Wang, KK; Tan, CC; Light, JG; et al.(2016). Genome-wide scleral micro-and messenger-RNA regulation during myopia development in the mouse. Investigative Ophthalmology and Visual Science, 57(14), 6089-6097. doi: 10.1167/iovs.16-19563. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/56g903dv
Investigative Ophthalmology & Visual Science
MicroRNAs (miRNAs) are small noncoding molecules that play pivotal roles in cell signaling through regulation of gene expression, specifically, by pairing with complementary messenger RNA (mRNA) sequences to either suppress translation or degrade mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e2d0e32925361df4223b723d384e3e
https://escholarship.org/uc/item/56g903dv
https://escholarship.org/uc/item/56g903dv
Publikováno v:
Journal of Biological Chemistry. 284:2072-2079
Reduced extracellular matrix accumulation in the sclera of myopic eyes leads to increased ocular extensibility and is related to reduced levels of scleral transforming growth factor-β (TGF-β). The current study investigated the impact of this extra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ca1754718b96e8b41a3fe77855ea983
https://doi.org/10.1074/jbc.m807521200
https://doi.org/10.1074/jbc.m807521200
Autor:
Ling Shen, Eric Jorgenson, Lisa F. Barcellos, Neil Risch, Ravikanth Metlapally, Catherine Schaefer, Ronald B. Melles, Lisa J. Herrinton, Christine F. Wildsoet
Publikováno v:
Ophthalmology, vol 123, iss 1
Purpose To evaluate the association between refractive error and the prevalence of glaucoma by race or ethnicity. Design Cross-sectional study. Participants Kaiser Permanente Northern California Health Plan members with refractive error measured at 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d7f4bb342bd4c43a4a5fa920b3be22
https://pubmed.ncbi.nlm.nih.gov/26707435
https://pubmed.ncbi.nlm.nih.gov/26707435
Autor:
Khanh-Nhat, Tran-Viet, Vincent, Soler, Valencia, Quiette, Caldwell, Powell, Tammy, Yanovitch, Ravikanth, Metlapally, Xiaoyan, Luo, Nicholas, Katsanis, Erica, Nading, Terri L, Young
Publikováno v:
Molecular Vision
Purpose Stickler syndrome is an arthro-ophthalmopathy with phenotypic overlap with Wagner syndrome. The common Stickler syndrome type I is inherited as an autosomal dominant trait, with causal mutations in collagen type II alpha 1 (COL2A1). Wagner sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2f42565ac4c5bd957d457fc5f51813f
https://pubmed.ncbi.nlm.nih.gov/23592912
https://pubmed.ncbi.nlm.nih.gov/23592912
Autor:
Sandrine Paget, Ravikanth Metlapally, Patrick Calvas, François Malecaze, David A. Mackey, Jeremy A. Guggenheim, Terri L. Young, Chang-Seok Ki, Diana Abbott, Yi-Ju Li, Thomas Rosenberg, Khanh-Nhat Tran-Viet
Purpose. Evidence from human myopia genetic mapping studies (MYP3 locus), modulated animal models, and observations of glycemic control in humans suggests that insulin-like growth factor (IGF)-1 plays a role in the control of eye growth. This study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c1133c27f5006d9a75d6ca783783de
Publikováno v:
Myopia: Animal Models to Clinical Trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::271edbd2911f2dd5c09f0ac7e1458e87
https://doi.org/10.1142/9789812832986_0010
https://doi.org/10.1142/9789812832986_0010