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Autor:
Victor E. Marquez, Peter M. Blumberg, Jeewoo Lee, Samira Benzaria, George W. A. Milne, Bruno Bienfait, Ravij Sharma, Shaomeng Wang, Kassoum Nacro, Kelly Teng, Nancy E. Lewin
Publikováno v:
Pharmacology & Therapeutics. 82:251-261
The pharmacophore-guided approach used in the first phase of the design of novel protein kinase C (PKC) ligands was based on the study of the geometry of bioequivalent pharmacophores present in diacylglycerol (DAG) and in the more potent phorbol este