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pro vyhledávání: '"Ravi Upasani"'
Autor:
Michael B. Bolger, Catherine L. Kimbrough, S. Hasan Tahir, R. M. Woodward, Edward R. Whittemore, Ravi Upasani, Derk J. Hogenkamp, Manuel Acosta-Burruel, Mian Alauddin, Nancy C. Lan, Kelvin W. Gee, Jon E. Hawkinson
Publikováno v:
Journal of Medicinal Chemistry. 40:61-72
Two naturally occurring metabolites of progesterone, 3 alpha-hydroxy-5 alpha- and 5 beta-pregnan-20-one (1 and 2), are potent allosteric modulators of the GABAA receptor. Their therapeutic potential as anxiolytics, anticonvulsants, and sedative/hypno