Výsledky vyhledávání - "Ravi Sitapara"

Pharmacologic characterization of GB002, a novel inhaled PDGFR kinase inhibitor in development for pulmonary arterial hypertension (PAH)

Autor: Luisa Salter-Cid, Eduardo Garcia, Debbie Slee, M. L. Kennedy, Anna Galkin, Bryan Clemons, Ravi Sitapara, Laura L. Carter, Larry Zisman

Publikováno v: Pulmonary hypertension.

Background: PAH is characterized by vascular remodeling, increased pulmonary arterial pressure (PAP) and right ventricular hypertrophy. Dysregulation of BMPR2 signaling is linked to hereditary and idiopathic forms of PAH. PDGF signaling plays an impo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a2ee3b2634bf900fe84e2378b5f815c
https://doi.org/10.1183/13993003.congress-2020.3550

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GAT107 Attenuates Inflammatory Lung Injury and Mortality in a Mouse Model of Ventilator-Associated Pneumonia by Mitigating Protein-S-Glutathionylation

Autor: Mosi Lin, Alex Gauthier, Ravi Sitapara, Abhijit Kulkarni, Ganesh S. Thakur, Jeanette C. Perron, Charles Ashby, Lin Mantell

Publikováno v: Free Radical Biology and Medicine. 180:s83

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60b9c37dc09b243280b95d63bd389631
https://doi.org/10.1016/j.freeradbiomed.2021.12.195

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Activation of NF-KB in Airway Epithelia Protects Against Hyperoxia-Induced Proinflammatory Lung Injury

Autor: Mao Wang, Matthew E. Poynter, Mohammad Javdan, Maria Entezari, Lin L. Mantell, Michelle Zur, Haichao Wang, Yvonne M. Janssen Heininger, John F. Alcorn, Dympna M.P. Morrow, Ravi Sitapara, Lee-Anne Daley, Charles R. Ashby

Publikováno v: Free Radical Biology and Medicine. 120:S63-S64

Hyperoxia-induced acute lung injury (HALI) during mechanical ventilation can lead to excessive proinflammatory responses, endothelial and epithelial cell damage, and alveolar edema. We and others have demonstrated that NF-kB activation has a protecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b690c7214b1f68b2e12157219d559c05
https://doi.org/10.1016/j.freeradbiomed.2018.04.210

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The redox regulation of damage-associated molecular pattern molecule HMGB1 in pulmonary disease

Autor: Lin L. Mantell, Dan Antoine, Ravi Sitapara, Mao Wang, Alex G. Gauthier

Publikováno v: Free Radical Biology and Medicine. 120:S88

HMGB1 is an endogenous molecule that can initiate and perpetuate inflammation. Previously, we have shown that airway HMGB1 mediates hyperoxia-induced acute lung injury and compromised innate immunity in cystic fibrosis and ventilator-associated pneum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23ddceff56487856a8fe92eb2912740c
https://doi.org/10.1016/j.freeradbiomed.2018.04.291

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Hyperoxia-induced macrophage dysfunction and acute lung injury are attenuated by modulation of α7nAChR via reduced HMGB1 hyperacetylation and release

Autor: Ganesh S. Thakur, Ravi Sitapara, Alex G. Gauthier, Lin L. Mantell

Publikováno v: Free Radical Biology and Medicine. 120:S88

Prolonged exposure to hyperoxia during mechanical ventilation (MV) can result in acute lung injury (ALI) and is associated with HMGB1 accumulation in the airways. The aim of this study was to determine whether modulation of α7 nicotinic acetylcholin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f6a8d18353371815442fdbce7fc15f5
https://doi.org/10.1016/j.freeradbiomed.2018.04.292

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