Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ravi S. Akundi"'
PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 1, Pp 469-478 (2012)
Mutations in the PARK6 gene coding for PTEN-induced kinase 1 (PINK1) cause recessive early-onset Parkinsonism. Although PINK1 and Parkin promote the degradation of depolarized mitochondria in cultured cells, little is known about changes in signaling
Externí odkaz:
https://doaj.org/article/1f4a8f99653b43d99d3ac0e26cea65fb
Autor:
Ravi S Akundi, Zhenyu Huang, Joshua Eason, Jignesh D Pandya, Lianteng Zhi, Wayne A Cass, Patrick G Sullivan, Hansruedi Büeler
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16038 (2011)
PTEN-induced kinase 1 (PINK1) is linked to recessive Parkinsonism (EOPD). Pink1 deletion results in impaired dopamine (DA) release and decreased mitochondrial respiration in the striatum of mice. To reveal additional mechanisms of Pink1-related dopam
Externí odkaz:
https://doaj.org/article/32effe2afdeb4ba387466e8ffa6afed5