Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Ravi R. Iyer"'
Autor:
Jung-Hoon Lee, Maren Thomsen, Herwin Daub, Stefan C. Steinbacher, Agnieszka Sztyler, Gabriel Thieulin-Pardo, Tobias Neudegger, Nikolay V. Plotnikov, Ravi R. Iyer, Hilary A. Wilkinson, Edith Monteagudo, Dan P. Felsenfeld, Tasir S. Haque, Michael Finley, Celia Dominguez, Thomas F. Vogt, Brinda C. Prasad
Huntington’s disease (HD) is fatal neurodegenerative disorder caused by the expansion of a CAG-repeat tract in the huntingtin (HTT) gene. Human and mouse genetics studies have demonstrated a role for DNA mismatch repair (MMR) proteins which control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183b5ff9f85869d81d144088519fcbbf
https://doi.org/10.1101/2023.05.08.539930
https://doi.org/10.1101/2023.05.08.539930
Autor:
Anna Pluciennik, Ravi R. Iyer
Publikováno v:
Journal of Huntington's Disease
DNA mismatch repair (MMR) is a highly conserved genome stabilizing pathway that corrects DNA replication errors, limits chromosomal rearrangements, and mediates the cellular response to many types of DNA damage. Counterintuitively, MMR is also involv
Autor:
Jochen Genschel, Paul Modrich, Basanta K. Dahal, Farid A. Kadyrov, Lyudmila Y. Kadyrova, Ravi R. Iyer
Publikováno v:
Proceedings of the National Academy of Sciences. 114:4930-4935
Eukaryotic MutLα (mammalian MLH1–PMS2 heterodimer; MLH1–PMS1 in yeast) functions in early steps of mismatch repair as a latent endonuclease that requires a mismatch, MutSα/β, and DNA-loaded proliferating cell nuclear antigen (PCNA) for activat
Publikováno v:
2017 Medicinal Chemistry Reviews ISBN: 9780996293242
2017 Medicinal Chemistry Reviews
2017 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50d9942c2287a02aefe8e4706e4af30d
https://doi.org/10.29200/acsmedchemrev-v52.ch20
https://doi.org/10.29200/acsmedchemrev-v52.ch20
Autor:
Joyce T. Reardon, Vanessa DeRocco, Ravi R. Iyer, Michael G. Kemp, Paul Modrich, Laura A. Lindsey-Boltz, Aziz Sancar
Publikováno v:
Journal of Biological Chemistry. 289:5074-5082
DNA repair and DNA damage checkpoints work in concert to help maintain genomic integrity. In vivo data suggest that these two global responses to DNA damage are coupled. It has been proposed that the canonical 30 nucleotide single-stranded DNA gap ge
Publikováno v:
Medicinal Chemistry Reviews ISBN: 9780996293235
Medicinal Chemistry Reviews
Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f534024c993c20cda64a0deaf04d6a3
https://doi.org/10.29200/acsmedchemrev-v51.ch11
https://doi.org/10.29200/acsmedchemrev-v51.ch11
Publikováno v:
Proceedings of the National Academy of Sciences. 110:12277-12282
MutLα endonuclease can be activated on covalently continuous DNA that contains a MutSα- or MutSβ-recognizable lesion and a helix perturbation that supports proliferating cell nuclear antigen (PCNA) loading by replication factor C, providing a pote
Autor:
Paul Modrich, Lorena S. Beese, Michael A. Hast, Ravi R. Iyer, Jillian Orans, Elizabeth McSweeney, Homme W. Hellinga
Publikováno v:
Cell. 145:212-223
SummaryHuman exonuclease 1 (hExo1) plays important roles in DNA repair and recombination processes that maintain genomic integrity. It is a member of the 5′ structure-specific nuclease family of exonucleases and endonucleases that includes FEN-1, X
Autor:
Jochen Genschel, Paul Modrich, Lorena S. Beese, Anna Pluciennik, Ravi R. Iyer, Miaw-sheue Tsai
Publikováno v:
The Journal of Biological Chemistry
MutSbeta (MSH2-MSH3) mediates repair of insertion-deletion heterologies but also triggers triplet repeat expansions that cause neurological diseases. Like other DNA metabolic activities, MutSbeta interacts with proliferating cell nuclear antigen (PCN
Autor:
Lorena S. Beese, Sihong Chen, Gregory L. Hura, Leonid Dzantiev, Ravi R. Iyer, Paul Modrich, Timothy J. Pohlhaus
Publikováno v:
Journal of Biological Chemistry. 283:13310-13319
We have examined the interaction parameters, conformation, and functional significance of the human MutSalpha(.) proliferating cell nuclear antigen (PCNA) complex in mismatch repair. The two proteins associate with a 1:1 stoichiometry and a K(D) of 0