Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ravi P. Cholia"'
Publikováno v:
Metabolic Brain Disease. 36:751-765
Pyruvate kinase (PK) catalyzes the last irreversible reaction of glycolysis pathway, generating pyruvate and ATP, from Phosphoenol Pyruvate (PEP) and ADP precursors. In mammals, four different tissue-specific isoforms (M1, M2, L and R) of PK exist, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15dde50e0db7212bf7d6b15446aecc15
https://doi.org/10.1007/s11011-021-00690-y
https://doi.org/10.1007/s11011-021-00690-y
Publikováno v:
Metabolic brain disease. 36(5)
Pyruvate kinase (PK) catalyzes the last irreversible reaction of glycolysis pathway, generating pyruvate and ATP, from Phosphoenol Pyruvate (PEP) and ADP precursors. In mammals, four different tissue-specific isoforms (M1, M2, L and R) of PK exist, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c280bdb0033626e6f881fd6ecaffb28
https://pubmed.ncbi.nlm.nih.gov/33651273
https://pubmed.ncbi.nlm.nih.gov/33651273
Publikováno v:
Metabolic Brain Disease. 33:1307-1326
Maintaining genomic integrity is essential for cell survival and viability. Reactive oxygen species (ROS) overproduction results in oxidative stress leading to the genomic instability via generation of small base lesions in DNA and these unrepaired D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9e2160a6af8dd9754f724c8198ec0f
https://doi.org/10.1007/s11011-018-0233-3
https://doi.org/10.1007/s11011-018-0233-3
Autor:
Manbir Kaur, Sanju Kumari, Raj Kumar, Saurabh Kumar, Manpreet Kaur, Monisha Dhiman, Anil K. Mantha, Ravi P. Cholia
Publikováno v:
Metabolic Brain Disease. 32:1705-1716
Glial cells protect themselves from the elevated reactive oxygen species (ROS) via developing unusual mechanisms to maintain the genomic stability, and reprogramming of the cellular antioxidant system to cope with the adverse effects. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10c10f82930ebdd35e3f9b7cc831bae4
https://doi.org/10.1007/s11011-017-0057-6
https://doi.org/10.1007/s11011-017-0057-6
Publikováno v:
Current Molecular Medicine. 15:932-943
Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) also known as Autotaxin, is a secreted lysophospholipase D, which hydrolyzes lysophosphatidylcholine (LPC) into Lysophosphatidic acid (LPA). LPA is the bioactive product of ENPP2 enzyme, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5d50dd1bcf236af0d0ccaa4469c9cf
https://doi.org/10.2174/1566524015666150921104804
https://doi.org/10.2174/1566524015666150921104804
Publikováno v:
Journal of Medicinal Chemistry. 57:10241-10256
The apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional enzyme involved in DNA repair and activation of transcription factors through its redox function. The evolutionarily conserved C- and N-termini are inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c306e9766928ed9f538148a00277e05c
https://doi.org/10.1021/jm500865u
https://doi.org/10.1021/jm500865u
Autor:
Sourav Kalra, Gaurav Joshi, Anil K. Mantha, Gagandeep Kaur, Ravi P. Cholia, Suyog M. Amrutkar, Raj Kumar, Uttam Chand Banerjee
Publikováno v:
Archiv der Pharmazie. 351:1800023
The design and synthesis of dihydropyrazolo[1,5-c]quinazolines (1a-h) as human topoisomerase II (TopoII) catalytic inhibitors are reported. The compounds were investigated for their antiproliferative activity against the C6 rat glial cell line. Two c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ea29f04de36835cda2eeb08a0c6b93
https://doi.org/10.1002/ardp.201800023
https://doi.org/10.1002/ardp.201800023
Autor:
Anil K. Mantha, Bibekananda Sarkar, Monisha Dhiman, Ravi P. Cholia, Shweta Thakur, Nandini Gautam
Publikováno v:
Experimental & Molecular Medicine
Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme involved in the base excision repair (BER) pathway, which repairs oxidative base damage caused by endogenous and exogenous agents. APE1 acts as a reductive activator of many tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcaea57a5b635f9368af654c561f29eb
https://pubmed.ncbi.nlm.nih.gov/25033834
https://pubmed.ncbi.nlm.nih.gov/25033834