Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ravi Nadimpalli"'
Publikováno v:
Scopus-Elsevier
We characterized the activation of interleukin-1β-converting enzyme (ICE)-like proteases (caspases) in human neuroblastoma cells (SH-SY5Y) following challenge with staurosporine, an established agent known to induce apoptosis. Time course analyses o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a6c597e6170c4b1d52abf1bdcafc78
https://doi.org/10.1046/j.1471-4159.1997.68062328.x
https://doi.org/10.1046/j.1471-4159.1997.68062328.x
Autor:
Michelle Huggins, Ravi Nadimpalli, Kim M. McGinnis, Kevin K.W. Wang, Jon S. Morrow, Susan B. Glantz, Rathna Nath
Publikováno v:
Neurochemistry International. 37:351-361
Alpha II-spectrin (alpha-fodrin) is a demonstrated endogenous substrate for caspase-3 in neurons undergoing unscheduled apoptotic death. We have previously identified the caspase cleavage site that yields the distinctive 120 kDa spectrin breakdown pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00cdd4320c5e6ff08004762cb6f0f12
https://doi.org/10.1016/s0197-0186(00)00040-1
https://doi.org/10.1016/s0197-0186(00)00040-1
Autor:
Desiree Watson, John L. Gilmore, Juan C. Jaen, Daniel Stafford, Nilam Amin, Rathna Nath, Ravi Nadimpalli, Kevin K.W. Wang, Bradley William Caprathe, Sheryl J. Hays, Kadee J. Raser, Walter Michael, Mark R. Emmerling
Publikováno v:
Journal of Medicinal Chemistry. 41:1060-1067
A series of 2-amino-4H-3,1-benzoxazin-4-ones have been synthesized and evaluated as inhibitors of the complement enzyme C1r. C1r is a serine protease at the beginning of the complement cascade, and complement activation by beta-amyloid may represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806e519321a1a2f2fc9825d26ce2597b
https://doi.org/10.1021/jm970394d
https://doi.org/10.1021/jm970394d
Autor:
Panaiyur S. Mohan, Rand Posmantur, Linda Herzog, Kevin K.W. Wang, Rathna Nath, Hamish Allen, Robert V. Talanian, Ravi Nadimpalli, Ralph A. Nixon, Martha Keegan
Publikováno v:
Archives of biochemistry and biophysics. 356(2)
Two cysteine protease families (caspase and calpain) participate in apoptosis. Here we report that the endogenous calpain inhibitor calpastatin is fragmented by caspase(s) to various extents during early apoptosis in two cell types. In anti-fas or st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7db9dd11536596fbbbe50c7fea7af0b
https://pubmed.ncbi.nlm.nih.gov/9705209
https://pubmed.ncbi.nlm.nih.gov/9705209
Autor:
Kadee J. Raser, Ravi Nadimpalli, Daniel Stafford, Kevin K.W. Wang, Rathna Nath, Kim M. McGinnis
Publikováno v:
Scopus-Elsevier
Both ice-like protease and calpain have been shown to be involved in apoptosis in non-neuronal cells. Cultured rat cerebellar granule neurons undergo apoptosis when exposed to low potassium-containing medium. Calpain inhibitors 3-(4-iodophenyl)-2-mer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ff84866ec19fb226ee14cf4091f006
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030893206&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030893206&partnerID=MN8TOARS
Autor:
Ravi Nadimpalli, Kadee J. Raser, Iradj Hajimohammadreza, Kevin K.W. Wang, Michele Scott, Rathna Nath
Publikováno v:
Scopus-Elsevier
Calpain (calcium-activated neutral protease) has been implicated as playing a role of neuronal injury in cerebral ischemia and excitotoxicity. Here we report that, in addition to extreme excitotoxic conditions [N-methyl-D-aspartate (NMDA), alpha-amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b24bf120b6ba56dd87b3fd0aaacf00
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030756917&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030756917&partnerID=MN8TOARS