Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ravi L. Rungta"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Pericytes are multifunctional cells of the vasculature that are vital to brain homeostasis, yet many of their fundamental physiological properties, such as Ca2+ signaling pathways, remain unexplored. We performed pharmacological and ion subs
Externí odkaz:
https://doaj.org/article/5328071b12c24621b176826d3adf8252
Autor:
Nicholas L. Weilinger, Kai Yang, Hyun B. Choi, Christopher J. Groten, Stefan Wendt, Madhuvika Murugan, Leigh E. Wicki-Stordeur, Louis-Philippe Bernier, Prashanth S. Velayudhan, Jiaying Zheng, Jeffrey M. LeDue, Ravi L. Rungta, John R. Tyson, Terrance P. Snutch, Long-Jun Wu, Brian A. MacVicar
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113128- (2023)
Summary: Neuronal swelling during cytotoxic edema is triggered by Na+ and Cl− entry and is Ca2+ independent. However, the causes of neuronal death during swelling are unknown. Here, we investigate the role of large-conductance Pannexin-1 (Panx1) ch
Externí odkaz:
https://doaj.org/article/15c0151341174dd0a284baf30f872a0d
Autor:
Ravi L. Rungta, Marc Zuend, Ali-Kemal Aydin, Éric Martineau, Davide Boido, Bruno Weber, Serge Charpak
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Rungta et al. utilized single whisker stimulation to map out functional hyperemia along vascular arbours from layer II/III to the surface of primary somatosensory cortex, in anesthetized and awake Thy1-GCaMP6 mice. They demonstrated the presence of a
Externí odkaz:
https://doaj.org/article/133ed17fe3fe40429aec716c0289e06f
Autor:
Ali-Kemal Aydin, William D. Haselden, Yannick Goulam Houssen, Christophe Pouzat, Ravi L. Rungta, Charlie Demené, Mickael Tanter, Patrick J. Drew, Serge Charpak, Davide Boido
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Neurovascular coupling refers to changes in cerebral blood flow in response to neuronal stimulation, but to what extent this change can report neuronal activation is not known. Here the authors develop transfer functions between neural calcium signal
Externí odkaz:
https://doaj.org/article/ca77cc2297bf43129c67c4233fb0779a
Autor:
Davide Boido, Ravi L. Rungta, Bruno-Félix Osmanski, Morgane Roche, Tomokazu Tsurugizawa, Denis Le Bihan, Luisa Ciobanu, Serge Charpak
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Neuronal activity leads to a local increase in blood flow and volume, a process termed hyperaemia. Here, the authors employ multiple imaging approaches of neuronal and vascular activity at varying resolution to delineate the spatiotemporal dynamics o
Externí odkaz:
https://doaj.org/article/caefeb2ed51248469672e890c4215216
Publikováno v:
eLife, Vol 8 (2019)
Previously, we reported the first oxygen partial pressure (Po2) measurements in the brain of awake mice, by performing two-photon phosphorescence lifetime microscopy at micrometer resolution (Lyons et al., 2016). However, this study disregarded that
Externí odkaz:
https://doaj.org/article/e22b75b4c59a4ba59ee157e29e2467aa
Pericytes are multifunctional cells of the vasculature that are vital to brain homeostasis, yet many of their fundamental physiological properties remain unexplored. Ca2+ is a ubiquitous second messenger across cell-types, where it mediates diverse f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1514806c7ac3225df98b759545467f62
https://doi.org/10.1101/2022.05.25.493438
https://doi.org/10.1101/2022.05.25.493438
Autor:
Joel Ramirez, Hedok Lee, Davide Boido, Joanna M. Wardlaw, Ravi L. Rungta, Humberto Mestre, Fergus N. Doubal, Kenneth Smith, Rosalind Brown, Bradley J. MacIntosh, Anne Joutel, Helene Benveniste, Lucia Ballerini, Allen Tannenbaum, Serge Charpak, Axel Montagne, Berislav V. Zlokovic, Sandra E. Black, Melanie D. Sweeney
Publikováno v:
Wardlaw, J M, Benveniste, H, Nedergaard, M, Zlokovic, B V, Mestre, H, Lee, H, Doubal, F N, Brown, R, Ramirez, J, MacIntosh, B J, Tannenbaum, A, Ballerini, L, Rungta, R L, Boido, D, Sweeney, M, Montagne, A, Charpak, S, Joutel, A, Smith, K J & Black, S E 2020, ' Perivascular spaces in the brain : anatomy, physiology and pathology ', Nature Reviews. Neurology, vol. 16, pp. 137-153 . https://doi.org/10.1038/s41582-020-0312-z
Wardlaw, J M, Benveniste, H, Nedergaard, M, Zlokovic, B V, Mestre, H, Lee, H, Doubal, F N, Brown, R, Ramirez, J, Macintosh, B J, Tannenbaum, A, Ballerini, L, Rungta, R L, Boido, D, Sweeney, M, Montagne, A, Charpak, S, Joutel, A, Smith, K J & Black, S E 2020, ' Perivascular spaces in the brain : anatomy, physiology and pathology ', Nature Reviews Neurology, vol. 16, no. 3, pp. 137-153 . https://doi.org/10.1038/s41582-020-0312-z
Wardlaw, J M, Benveniste, H, Nedergaard, M, Zlokovic, B V, Mestre, H, Lee, H, Doubal, F N, Brown, R, Ramirez, J, Macintosh, B J, Tannenbaum, A, Ballerini, L, Rungta, R L, Boido, D, Sweeney, M, Montagne, A, Charpak, S, Joutel, A, Smith, K J & Black, S E 2020, ' Perivascular spaces in the brain : anatomy, physiology and pathology ', Nature Reviews Neurology, vol. 16, no. 3, pp. 137-153 . https://doi.org/10.1038/s41582-020-0312-z
Perivascular spaces include a variety of passageways around arterioles, capillaries and venules in the brain, along which a range of substances can move. Although perivascular spaces were first identified over 150 years ago, they have come to promine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fde4a92578b32a8fc5bb081e21d71f
https://curis.ku.dk/ws/files/290446533/Wardlaw_edited_accepted_1575044479_2_JMW.pdf
https://curis.ku.dk/ws/files/290446533/Wardlaw_edited_accepted_1575044479_2_JMW.pdf
Autor:
Louis-Philippe Bernier, Christopher J. Groten, Brian A. MacVicar, Jeffrey M. LeDue, Ravi L. Rungta, Sibyl Drissler, Rebecca W.Y. Ko, Lasse Dissing-Olesen
Publikováno v:
Glia. 64:2093-2103
Astrocytes display complex morphologies with an array of fine extensions extending from the soma and the primary thick processes. Until the use of genetically encoded calcium indicators (GECIs) selectively expressed in astrocytes, Ca2+ signaling was