Orai, RyR, and IP3R channels cooperatively regulate calcium signaling in brain mid-capillary pericytes

Autor: Braxton Phillips, Jenna Clark, Éric Martineau, Ravi L. Rungta

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)

Abstract Pericytes are multifunctional cells of the vasculature that are vital to brain homeostasis, yet many of their fundamental physiological properties, such as Ca2+ signaling pathways, remain unexplored. We performed pharmacological and ion subs

Externí odkaz: https://doaj.org/article/5328071b12c24621b176826d3adf8252

Diversity of neurovascular coupling dynamics along vascular arbors in layer II/III somatosensory cortex

Autor: Ravi L. Rungta, Marc Zuend, Ali-Kemal Aydin, Éric Martineau, Davide Boido, Bruno Weber, Serge Charpak

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)

Rungta et al. utilized single whisker stimulation to map out functional hyperemia along vascular arbours from layer II/III to the surface of primary somatosensory cortex, in anesthetized and awake Thy1-GCaMP6 mice. They demonstrated the presence of a

Externí odkaz: https://doaj.org/article/133ed17fe3fe40429aec716c0289e06f

Mesoscopic and microscopic imaging of sensory responses in the same animal

Autor: Davide Boido, Ravi L. Rungta, Bruno-Félix Osmanski, Morgane Roche, Tomokazu Tsurugizawa, Denis Le Bihan, Luisa Ciobanu, Serge Charpak

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Neuronal activity leads to a local increase in blood flow and volume, a process termed hyperaemia. Here, the authors employ multiple imaging approaches of neuronal and vascular activity at varying resolution to delineate the spatiotemporal dynamics o

Externí odkaz: https://doaj.org/article/caefeb2ed51248469672e890c4215216

Light controls cerebral blood flow in naive animals

Autor: Ravi L Rungta, Bruno-Félix Osmanski, Davide Boido, Mickael Tanter, Serge Charpak

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)

Combination of optogenetics and BOLD fMRI is routinely used to map neuronal activity upon photostimulation. Here the authors show that light, shone at intensities used in optogenetic studies, dilates vessels and increases blood flow independently of

Externí odkaz: https://doaj.org/article/bc97a90bf9ce4201af5c6af664e8e40f

Perivascular spaces in the brain:anatomy, physiology and pathology

Autor: Joel Ramirez, Hedok Lee, Davide Boido, Joanna M. Wardlaw, Ravi L. Rungta, Humberto Mestre, Fergus N. Doubal, Kenneth Smith, Rosalind Brown, Bradley J. MacIntosh, Anne Joutel, Helene Benveniste, Lucia Ballerini, Allen Tannenbaum, Serge Charpak, Axel Montagne, Berislav V. Zlokovic, Sandra E. Black, Melanie D. Sweeney

Publikováno v: Wardlaw, J M, Benveniste, H, Nedergaard, M, Zlokovic, B V, Mestre, H, Lee, H, Doubal, F N, Brown, R, Ramirez, J, MacIntosh, B J, Tannenbaum, A, Ballerini, L, Rungta, R L, Boido, D, Sweeney, M, Montagne, A, Charpak, S, Joutel, A, Smith, K J & Black, S E 2020, ' Perivascular spaces in the brain : anatomy, physiology and pathology ', Nature Reviews. Neurology, vol. 16, pp. 137-153 . https://doi.org/10.1038/s41582-020-0312-z
Wardlaw, J M, Benveniste, H, Nedergaard, M, Zlokovic, B V, Mestre, H, Lee, H, Doubal, F N, Brown, R, Ramirez, J, Macintosh, B J, Tannenbaum, A, Ballerini, L, Rungta, R L, Boido, D, Sweeney, M, Montagne, A, Charpak, S, Joutel, A, Smith, K J & Black, S E 2020, ' Perivascular spaces in the brain : anatomy, physiology and pathology ', Nature Reviews Neurology, vol. 16, no. 3, pp. 137-153 . https://doi.org/10.1038/s41582-020-0312-z

Perivascular spaces include a variety of passageways around arterioles, capillaries and venules in the brain, along which a range of substances can move. Although perivascular spaces were first identified over 150 years ago, they have come to promine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fde4a92578b32a8fc5bb081e21d71f
https://curis.ku.dk/ws/files/290446533/Wardlaw_edited_accepted_1575044479_2_JMW.pdf