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pro vyhledávání: '"Ravi Kurambail"'
Autor:
Dean Messing, Win Naing, Joseph P. Portanova, Tina Kim, Alan G. Benson, Shaun R. Selness, Daniel L. Flynn, Joseph B. Monahan, Richard Lindmark, Huey S. Shieh, John K. Walker, Syaulan Yang, Ravi Kurambail, Rajesh V. Devraj, Michael Hepperle, Dice Tom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2634-2638
Starting from an initial HTS screening lead, a novel series of C(5)-substituted diaryl pyrazoles were developed that showed potent inhibition of p38alpha kinase. Key to this outcome was the switch from a pyridyl to pyrimidine at the C(4)-position lea