Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Ravi Kumar Pedapati"'
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Substrate-directed Synthesis of Isocoumarin and 3-Ylidenephthalide Conjugated Noscapinoids and their Antiproliferative Activities
Autor: Ravi Kumar Pedapati, Nagaraju Chirra, Naga Pranathi Abburi, Rakesh Bollikonda, Danaboiena Alekhya, Balasubramanian Sridhar, Pradeep K. Naik, Srinivas Kantevari
Publikováno v: Chemistry, an Asian journal.
A series of new noscapinoids designed; synthesized and assessed whether its 3-ylidenephthalide and isocoumarin conjugates improved cytotoxicity. Cu-catalysed Sonogashira coupling of N-propargyl noscapine with 2-bromobenzoic acids followed by in-situ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae359e937a0a7971758a646b38affa53
https://pubmed.ncbi.nlm.nih.gov/36416383
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4
Aryl-n-hexanamide linked enaminones of usnic acid as promising antimicrobial agents
Autor: Pavan Kumar Bangalore, Ravi Kumar Pedapati, Abburi Naga Pranathi, Uma Rajeswari Batchu, Sunil Misra, Madhurekha Estharala, Dharmarajan Sriram, Srinivas Kantevari
Publikováno v: Molecular diversity.
Lichen secondary metabolites are well explored medicinal agents with diverse pharmacological properties. One of the important antibiotic lichen secondary metabolites is usnic acid. Its diverse medicinal profiles prompted us to explore it as a potenti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3328b5c9bf5fae82f76e230e293b7e61
https://pubmed.ncbi.nlm.nih.gov/35608808
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5
9-Ethynyl noscapine induces G2/M arrest and apoptosis by disrupting tubulin polymerization in cervical cancer
Autor: Anjana Devi Tangutur, Srinivas Kantevari, Ravi Kumar Pedapati, Vamsi Krishna Kommalapati, Praveen Kumar Reddy Nagireddy, Venkateswarlu Kojja, Dinesh Kumar
Publikováno v: Drug development researchREFERENCES. 83(3)
Noscapine is a phthalide isoquinoline alkaloid present in the latex of Papaver somniferum and has demonstrated potent antitumor activity in various cancer models. Structural changes in the core molecule of noscapine architecture have produced a numbe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5cf47f6c73ebb5d578764c35092524
https://pubmed.ncbi.nlm.nih.gov/34612529
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6
Rational design of novel N-alkyl amine analogues of noscapine, their chemical synthesis and cellular activity as potent anticancer agents
Autor: Ravi Kumar Pedapati, Srinivas Kantevari, Rajesh Kumar Meher, Praveen Kumar Reddy Nagireddy, Arnab Nayek, Pradeep Kumar Naik, Pratyush Pragyandipta
Publikováno v: Chemical biologydrug designREFERENCES. 98(3)
The scaffold structure of noscapine (an antitussive plant alkaloid) was modified by inducting N-aryl methyl pharmacophore at C-9 position of the isoquinoline ring to rationally design and screened three novel 9-(N-arylmethylamino) noscapinoids, 15-17
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972e10b4f710df3cc2d599a67f631f61
https://pubmed.ncbi.nlm.nih.gov/34051055
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7
Rational design, chemical synthesis and cellular evaluation of novel 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents
Autor: Srinivas Kantevari, Praveen Kumar Reddy, Amiya Kumar Patel, Ravi Kumar Pedapati, Pratyush Pragyandipta, Manas Ranjan Naik, Rajesh Kumar Meher, Pradeep Kumar Naik
Publikováno v: Journal of Molecular Graphics and Modelling. 106:107933
We present a new class of derivatives of noscapine, 1,3-diynyl-noscapinoids of an antitussive plant alkaloid, noscapine based on our in silico efforts that binds tubulin and displays anticancer activity against a panel of breast cancer cells. Structu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f2e56123328955633fab7e2aa3531c
https://doi.org/10.1016/j.jmgm.2021.107933
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