Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ravi Kiran Koripella"'
Autor:
Adrián González-López, Daniel S. D. Larsson, Ravi Kiran Koripella, Brett N. Cain, Martin Garcia Chavez, Paul J. Hergenrother, Suparna Sanyal, Maria Selmer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The antibiotic fusidic acid (FA) is used to treat Staphylococcus aureus infections. It inhibits protein synthesis by binding to elongation factor G (EF-G) and preventing its release from the ribosome after translocation. While FA, due to per
Externí odkaz:
https://doaj.org/article/688e7a88add545d890d90508e053347f
Autor:
Ravi Kiran Koripella, Ayush Deep, Ekansh K. Agrawal, Pooja Keshavan, Nilesh K. Banavali, Rajendra K. Agrawal
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
High-resolution cryo-EM structures and biochemical analyses of the human mitoribosome, in complex with mitochondria-specific factors mediating mitoribosome recycling, RRFmt and EF-G2mt, offer insight into mechanisms of mitoribosome recycling and resi
Externí odkaz:
https://doaj.org/article/72b116d70c9243d7a6170b9fd638970d
Autor:
Ravi Kiran Koripella, Manjuli R. Sharma, Kalpana Bhargava, Partha P. Datta, Prem S. Kaushal, Pooja Keshavan, Linda L. Spremulli, Nilesh K. Banavali, Rajendra K. Agrawal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Translation within mitochondria is carried out by specialized mitoribosomes and translational factors. Here the authors describe cryo-EM structures of the human mitochondrial translation elongation factor G1 in complex with human mitoribosomes, revea
Externí odkaz:
https://doaj.org/article/7811cccf65184e81a96fed86561d888f
Autor:
Jesper Pallesen, Yaser Hashem, Gürkan Korkmaz, Ravi Kiran Koripella, Chenhui Huang, Måns Ehrenberg, Suparna Sanyal, Joachim Frank
Publikováno v:
eLife, Vol 2 (2013)
Termination of messenger RNA translation in Bacteria and Archaea is initiated by release factors (RFs) 1 or 2 recognizing a stop codon in the ribosomal A site and releasing the peptide from the P-site transfer RNA. After release, RF-dissociation is f
Externí odkaz:
https://doaj.org/article/f69407db36ae420186481b22072f966e
Autor:
Xiaohu Guo, Kristin Peisker, Kristina Bäckbro, Yang Chen, Ravi Kiran Koripella, Chandra Sekhar Mandava, Suparna Sanyal, Maria Selmer
Publikováno v:
Open Biology, Vol 2, Iss 3 (2012)
Fusidic acid (FA) is a bacteriostatic antibiotic that locks elongation factor G (EF-G) to the ribosome after GTP hydrolysis during elongation and ribosome recycling. The plasmid pUB101-encoded protein FusB causes FA resistance in clinical isolates of
Externí odkaz:
https://doaj.org/article/433cc239a5c4416486661bd84da90e9f
Autor:
Nilesh K. Banavali, Linda L. Spremulli, Ravi Kiran Koripella, Rajendra K. Agrawal, Prem Singh Kaushal, Manjuli R. Sharma, Pooja Keshavan, Kalpana Bhargava, Partha P. Datta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
The mammalian mitochondrial ribosome (mitoribosome) and its associated translational factors have evolved to accommodate greater participation of proteins in mitochondrial translation. Here we present the 2.68–3.96 Å cryo-EM structures of the huma
Autor:
Rajendra K. Agrawal, Paul Risteff, Manjuli R. Sharma, Ravi Kiran Koripella, Linda L. Spremulli, Md. Emdadul Haque
Publikováno v:
iScience
iScience, Vol 12, Iss, Pp 76-86 (2019)
iScience, Vol 12, Iss, Pp 76-86 (2019)
Summary The human mitochondrial translational initiation factor 3 (IF3mt) carries mitochondrial-specific amino acid extensions at both its N and C termini (N- and C-terminal extensions [NTE and CTE, respectively]), when compared with its eubacterial
Autor:
Yunlong Li, Manjuli R. Sharma, Ravi Kiran Koripella, Anil K. Ojha, Rajendra K. Agrawal, Richard E. Lee
Publikováno v:
Antimicrobial Agents and Chemotherapy
Zinc is an essential micronutrient for mycobacteria, and its depletion induces multiple adaptive changes in cellular physiology, the most remarkable of which are remodeling and hibernation of ribosomes. Ribosome remodeling, induced upon relatively mo
Autor:
Yunlong Li, Ravi Kiran Koripella, Nilesh K. Banavali, Anil K. Ojha, Rajendra K. Agrawal, Manjuli R. Sharma
Publikováno v:
Microbiology (Reading)
Treatment of tuberculosis requires a multi-drug regimen administered for at least 6 months. The long-term chemotherapy is attributed in part to a minor subpopulation of nonreplicatingMycobacterium tuberculosiscells that exhibit phenotypic tolerance t
Autor:
Pooja Keshavan, Rajendra K. Agrawal, Ravi Kiran Koripella, Ayush Deep, Nilesh K. Banavali, Ekansh K. Agrawal
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Ribosomes are recycled for a new round of translation initiation by dissociation of ribosomal subunits, messenger RNA and transfer RNA from their translational post-termination complex. Here we present cryo-EM structures of the human 55S mitochondria