Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Ravi Kanth Bhamidipati"'
Autor:
Vinod Anera Balakrishna, Anitha Police, Rakesh Hiremath, Anusha Raj, Suresh P Sulochana, Devaraj V Chandrasekhar, Zainuddin Mohd, Ravi Kanth Bhamidipati, Ramesh Mullangi
Publikováno v:
ADMET and DMPK, Vol 5, Iss 4, Pp 212-223 (2017)
Ulixertinib (BVD-523) is a novel and selective reversible inhibitor of ERK1/ERK2. In xenograft studies it inhibited tumor growth in BRAF-mutant melanoma and colorectal xenografts as well as KRAS-mutant colorectal and pancreatic models. Ulixertinib is
Externí odkaz:
https://doaj.org/article/1b1002ea1d4d436594942db8e2f76ff9
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 18, Iss 3 (2015)
Purpose: The purpose of this exercise was to explore the utility of allometric scaling approach for the prediction of intravenous and oral pharmacokinetics of six dipeptidy peptidase-IV (DPP-IV) inhibitors viz. ABT-279, ABT-341, alogliptin, carmeglip
Externí odkaz:
https://doaj.org/article/5c77592ad2354919b0695b3df1032d2d
Autor:
Pat Brady, Naveena Madhyastha, Ravi Kanth Bhamidipati, Zainuddin Mohd, Dave Downie, Matthew J. Cato, Hong Lin, Céline Rouget, Tania Bakshi, Khuram W. Chaudhary, Dwight M. Morrow, Brian Donovan, Yasuji Matsuoka, Mark A. Seefeld, Kishore Pasikanti, Sridharan Rajagopal, Joerg Holenz, Wei Zhen, Robert W. Dougherty, Mark L. Chapman, Swapan Kumar Samanta, Tingting Fu, Philippe Lluel, Bharathi Mohan Kuppusamy, Guy A. Higgins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3793-3797
Neuronal voltage-gated potassium channels, KV7s, are the molecular mediators of the M current and regulate membrane excitability in the central and peripheral neuronal systems. Herein, we report novel small molecule KV7 openers that demonstrate anti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfef453d358d286fe6210e7d6cffeb3f
https://doi.org/10.1016/j.bmcl.2018.09.036
https://doi.org/10.1016/j.bmcl.2018.09.036
Autor:
Ramesh Mullangi, Devaraj V. Chandrashekar, Ravi Kanth Bhamidipati, Ziyu Li, Juluri Suresh, Saravanakumar Dhakshinamoorthy, Sreekanth Dittakavi, Lavanya Mahadevan, Felix Baerenz, Norbert Tennagels
Publikováno v:
Biomedical Chromatography. 34
Ceramides are known to be involved in various biological processes with their physiological levels elevated in various disease conditions such as diabetes, Alzheimer's, atherosclerosis. To facilitate the rapid screening of Cer d18:1/16:0, d18:1/24:0,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abc4f636e401ab0d031056f1070be09
https://doi.org/10.1002/bmc.4790
https://doi.org/10.1002/bmc.4790
Autor:
Ramesh Mullangi, Wolfgang F. Richter, Ravi Kumar Jairam, Sadanand Rangnathrao Mallurwar, Suresh P. Sulochana, Ravi Kanth Bhamidipati, Nuggehally R. Srinivas, Devaraj Venkatapura Chandrasekar
Publikováno v:
Drug Research. 69:32-39
Bendamustine, an alkylating anticancer agent, is used to treat chronic lymphocytic leukemia by intravenous infusion alone or in combination. The work aimed to develop a method to predict time vs. concentration profile for humans based on preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce97bd1f6cb638a6f6f08924febec6a9
https://doi.org/10.1055/a-0640-8977
https://doi.org/10.1055/a-0640-8977
Autor:
Nisha K. Anchan, Thomas Langer, Vishal Subhash Mane, Raghunadha Reddy Burri, Christine Rudolph, Herman Schreuder, Joerg Czech, Ramachandraiah Gosu, Rajendra Kristam, Saravanakumar Dhakshinamoorthy, Ramesh Mullangi, Juluri Suresh, Mahanandeesha S. Hallur, Sridharan Rajagopal, Takeshi Yura, Manvi Singh, Aimo Kannt, Devaraj Venkatapura Chandrasekar, Shama Shaik, Sanjay Venkatachalapathi Kadnur, V.P. Rama Kishore Putta, Lokesh Kananti Narasimhulu, Karthikai Raj Murugesan, Ravi Kanth Bhamidipati, Sven Ruf, Indu N. Swamy, Alexander Marker, Sayantani Sarkar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:922-925
Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that inhibited NNMT enzymatic activity and reduced the formation of 1-methyl-nicotinamide (MNA), the pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0692f15941b73b65689828e71e37e26f
https://doi.org/10.1016/j.bmcl.2018.01.058
https://doi.org/10.1016/j.bmcl.2018.01.058
Autor:
Ravi Kumar Jairam, Ramesh Mullangi, Rakesh A. Hiremath, Anera Balakrishna Vinod, Anusha Raj, Ravi Kanth Bhamidipati, Devaraj V. Chandrasekhar, P. Suresh, Mohd Zainuddin
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 43:453-460
Ulixertinib (BVD-523) is a novel and selective reversible inhibitor of ERK1/ERK2. The primary objectives of the study were to evaluate the pharmacokinetics of ulixertinib in mice, rats, and dogs followed by prediction of human pharmacokinetic profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca8b8d025fa33c5b68ed199dbc464f6
https://doi.org/10.1007/s13318-018-0465-y
https://doi.org/10.1007/s13318-018-0465-y
Autor:
Srinivasan Swaminathan, Rajendra Kristam, Manish Kumar Thakur, Anja Pfenninger, Vishal Subhash Mane, Saravanakumar Dhakshinamoorthy, Ralf Elvert, Saravanan Kandan, Niranjan Naranapura Anand, Takeshi Yura, Reejuana Parveen, Ravi Kanth Bhamidipati, Devaraj Venkatapura Chandrasekar, Ramesh Mullangi, Sridharan Rajagopal, Raghunadha Reddy Burri, Herman Schreuder, Mahanandeesha S. Hallur, Sven Ruf, Manvi Singh, Jörg Czech, Juluri Suresh, Ramachandraiah Gosu, Shama Shaik, Sanjay Venkatachalapathi Kadnur, Swarnakumari Birudukota, Bharat Ravindra Zope, Aimo Kannt, Christine Rudolph
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports
Scientific Reports
Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the transfer of a methyl group from the co-factor S-adenosyl-L-methionine (SAM) onto the substrate, nicotinamide (NA) to form 1-methyl-nicotinamide (MNA). Higher NNMT expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c01f24269126b297e24b498d6f605e4
http://link.springer.com/article/10.1038/s41598-018-22081-7
http://link.springer.com/article/10.1038/s41598-018-22081-7
Autor:
Umesh Todmal, Gurulingappa Hallur, Ramesh Mullangi, Sridharan Rajagopal, Suresh P. Sulochana, Ravi Kanth Bhamidipati, Swapan Kumar Samanta, Mohd Zainuddin, Sriram Rajagopal
Publikováno v:
Chromatographia. 81:457-468
A sensitive and rapid LC–MS/MS method was developed and validated for the simultaneous quantitation of five selective KCNQ channel openers, namely ICA-27243, ML-213, PF-05020182, SF-0034 and flupirtine in mice plasma as per regulatory guideline. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc1ef7004177cd1b0e45d532fbab906f
https://doi.org/10.1007/s10337-018-3472-x
https://doi.org/10.1007/s10337-018-3472-x
Autor:
Ramesh Mullangi, Neeraj Kumar Saini, Ravi Kanth Bhamidipati, P. Suresh, Mahalakhsmi Lella, Sriram Rajagopal
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 148:100-107
A sensitive, specific and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of tideglusib in mice plasma using warfarin as an internal standard (I.S.) as per regulatory guidelines. Sample preparation was accomplished t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c714ef33c0a96babe62c8f34066ba32
https://doi.org/10.1016/j.jpba.2017.09.022
https://doi.org/10.1016/j.jpba.2017.09.022