Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Ravi K. Sajja"'
Publikováno v:
BMC Neuroscience, Vol 20, Iss 1, Pp 1-8 (2019)
Abstract Background The use of siRNA-based gene silencing has been recently underscored as a potential therapeutic strategy for the treatment of neurological disorders. However, the stability of siRNA and other small molecule therapeutics is challeng
Externí odkaz:
https://doaj.org/article/8a79d46aa52340ca8888a16230d47b6b
Publikováno v:
BMC Neuroscience, Vol 18, Iss 1, Pp 1-13 (2017)
Abstract Background A sensitive, rapid and selective UHPLC–MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using Continine-d 3 as internal standard (IS) as per FDA guidelines. Sample preparati
Externí odkaz:
https://doaj.org/article/b9452f9883784dc988035a5a31a6ce52
Autor:
Mohammad A. Kaisar, Heidi Villalba, Shikha Prasad, Taylor Liles, Ali Ehsan Sifat, Ravi K. Sajja, Thomas J. Abbruscato, Luca Cucullo
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 353-362 (2017)
Recently published in vitro and in vivo findings strongly suggest that BBB impairment and increased risk for stroke by tobacco smoke (TS) closely resemble that of type-2 diabetes (2DM) and develop largely in response to common key modulators such oxi
Externí odkaz:
https://doaj.org/article/6fb3f203a3f348798d42ad18c33f8904
Autor:
Shikha Prasad, Ravi K. Sajja, Mohammad Abul Kaisar, Jee Hyun Park, Heidi Villalba, Taylor Liles, Thomas Abbruscato, Luca Cucullo
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 58-69 (2017)
Cigarette smoking (CS) is associated with vascular endothelial dysfunction in a causative way primarily related to the TS content of reactive oxygen species (ROS), nicotine, and inflammation. TS promotes glucose intolerance and increases the risk of
Externí odkaz:
https://doaj.org/article/4703dbec5c76403b8657c93f59e81775
Autor:
Shikha Prasad, Mohammad A. Kaisar, Vikrant Vijay, Ravi K. Sajja, Luca Cucullo, Varsha G. Desai
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Sulforaphane (SFN) has been shown to protect the brain vascular system and effectively reduce ischemic injuries and cognitive deficits. Given the robust cerebrovascular protection afforded by SFN, the objective of this study was to profile these effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2600d6af282efb9aceb5bebc1bc7143
http://link.springer.com/article/10.1038/s41598-018-31137-7
http://link.springer.com/article/10.1038/s41598-018-31137-7
Autor:
Mohammad A. Kaisar, Jee Hyun Park, Ravi K. Sajja, Luca Cucullo, Thomas J. Abbruscato, Taylor Liles, Shikha Prasad, Heidi Villalba
Publikováno v:
Redox Biology, Vol 12, Iss, Pp 58-69 (2017)
Redox Biology
Redox Biology
Cigarette smoking (CS) is associated with vascular endothelial dysfunction in a causative way primarily related to the TS content of reactive oxygen species (ROS), nicotine, and inflammation. TS promotes glucose intolerance and increases the risk of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9435a62e0fcaf158a4abba1c5f4b96
http://www.sciencedirect.com/science/article/pii/S2213231717300484
http://www.sciencedirect.com/science/article/pii/S2213231717300484
Publikováno v:
Neuroscience Letters. 653:152-158
Blood-brain barrier (BBB) damage is a critical neurovascular complication of diabetes mellitus that adversely affects the CNS health and function. Previously, we showed the protective role of NF-E2 related factor-2 (Nrf2), a redox sensitive transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a29432e4b0477fc0dd0b433fa4e5608
https://doi.org/10.1016/j.neulet.2017.05.059
https://doi.org/10.1016/j.neulet.2017.05.059
Autor:
Shikha Prasad, Taylor Liles, Vinay V. Abhyankar, Ravi K. Sajja, Luca Cucullo, Mohammad A. Kaisar
Publikováno v:
Expert Opinion on Drug Discovery. 12:89-103
The blood-brain barrier (BBB) is a dynamic biological interface which actively controls the passage of substances between the blood and the central nervous system (CNS). From a biological and functional standpoint, the BBB plays a crucial role in mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155edb76030ef148a9e5b86d7600dc55
https://doi.org/10.1080/17460441.2017.1253676
https://doi.org/10.1080/17460441.2017.1253676
Publikováno v:
BMC Neuroscience
BMC Neuroscience, Vol 20, Iss 1, Pp 1-8 (2019)
BMC Neuroscience, Vol 20, Iss 1, Pp 1-8 (2019)
Background The use of siRNA-based gene silencing has been recently underscored as a potential therapeutic strategy for the treatment of neurological disorders. However, the stability of siRNA and other small molecule therapeutics is challenged by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547397b6c062d7fb547adfc836b7ce98
https://pubmed.ncbi.nlm.nih.gov/31068126
https://pubmed.ncbi.nlm.nih.gov/31068126
Autor:
Ravi K. Sajja, Luca Cucullo
Publikováno v:
Neuroscience Letters. 598:59-65
The unique phenotype of blood-brain barrier (BBB) endothelium is partly maintained by abundant expression of ATP-binding cassette superfamily of efflux transporters that strictly restrict the CNS access to toxic substances including xenobiotics in ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14eafeb140afe887e70653beae216c02
https://doi.org/10.1016/j.neulet.2015.05.015
https://doi.org/10.1016/j.neulet.2015.05.015