Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ravi K. R. Marreddy"'
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT Ebselen, a reactive organoselenium compound, was shown to inhibit toxins TcdA and TcdB by covalently binding to their cysteine protease domains. It was suggested that ebselen lacked antimicrobial activity against Clostridioides difficile. Ho
Externí odkaz:
https://doaj.org/article/2b0122cbcf7f4fce991449fb0b7fa390
Autor:
Laetitia Daury, François Orange, Jean-Christophe Taveau, Alice Verchère, Laura Monlezun, Céline Gounou, Ravi K. R. Marreddy, Martin Picard, Isabelle Broutin, Klaas M. Pos, Olivier Lambert
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Tripartite efflux systems consist of inner membrane, outer membrane and periplasmic components. Here, Daury et al. reconstitute native versions of RND transporters in nanodiscs and present projection structures emphasizing the role of the periplasmic
Externí odkaz:
https://doaj.org/article/eba793de8123457e92c40e3142a2ad4f
Autor:
Ravi K. R. Marreddy, Jonathan Picker, Gregory A. Phelps, Reid Powell, Philip T. Cherian, John J. Bowling, Clifford C. Stephan, Richard E. Lee, Julian G. Hurdle
Toxins TcdA and TcdB are the main virulence factors of Clostridioides difficile, a leading cause of hospital-acquired diarrhea. We investigated the therapeutic potential of inhibiting the biosynthesis of TcdA and TcdB. Accordingly, screening of struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24ae292774bfbac26706fdaa554e8932
https://doi.org/10.1101/2022.04.20.488993
https://doi.org/10.1101/2022.04.20.488993
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
Microbiology Spectrum
Microbiology Spectrum
Ebselen, a reactive organoselenium compound, was shown to inhibit toxins TcdA and TcdB by covalently binding to their cysteine protease domains. It was suggested that ebselen lacked antimicrobial activity against Clostridioides difficile. However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71389594f993c79e8643c0ce1ae2b04
https://journals.asm.org/doi/10.1128/Spectrum.00448-21
https://journals.asm.org/doi/10.1128/Spectrum.00448-21
Autor:
Dianqing Sun, Julian G Hurdle, Ravi K. R. Marreddy, Kirk E. Hevener, Rebecca D Wahrmund, Jesse A. Jones, Allan M. Prior
Publikováno v:
ACS Chem Biol
Clostridioides difficile infection (CDI) is a leading cause of significant morbidity, mortality, and healthcare-related costs in the United States. After standard therapy, recurrence rates remain high, and multiple recurrences are not uncommon. Cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb17007256f17bacf15a7a58d4e436a3
https://doi.org/10.1021/acschembio.9b00293
https://doi.org/10.1021/acschembio.9b00293
Autor:
Xiaoqian Wu, Dianqing Sun, Kirk E. Hevener, Ravi K. R. Marreddy, Julian G Hurdle, Madhab Sapkota, Jesse A. Jones, Allan M. Prior
Publikováno v:
ACS Infectious Diseases. 5:208-217
Clostridium difficile infection (CDI) is an antibiotic-induced microbiota shift disease of the large bowel. While there is a need for narrow-spectrum CDI antibiotics, it is unclear which cellular proteins are appropriate drug targets to specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d46b5e2ce5d95d1b1b2c3d5ef98e27
https://doi.org/10.1021/acsinfecdis.8b00205
https://doi.org/10.1021/acsinfecdis.8b00205
High recurrence rates and spread of antibiotic-resistant strains necessitate the need for alternative therapeutics for Clostridioides difficile infections (CDIs). Ebselen, a reactive organoselenium compound inhibits C. difficile virulence toxins TcdA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::885fa155ffda6399af97a4509f8a1d8c
https://doi.org/10.1101/2020.07.27.224337
https://doi.org/10.1101/2020.07.27.224337
Autor:
Dinesh M. Fernando, Julian G Hurdle, Martin N. Cheramie, Richard E. Lee, Ravi K. R. Marreddy, Philip T. Cherian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3105-3112
β-Lactams are the most important class of antibiotics, for which the emergence of resistance threatens their utility. As such, we explored the extent to which the tetramic acid motif, frequently found in naturally occurring antibiotics, can be used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71bf5ca927a080d7c564be644cccc42a
https://doi.org/10.1016/j.bmcl.2018.07.018
https://doi.org/10.1016/j.bmcl.2018.07.018
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21873 (2011)
BACKGROUND: Membrane proteins comprise an important class of molecules whose study is largely frustrated by several intrinsic constraints, such as their hydrophobicity and added requirements for correct folding. Additionally, the complexity of the ce
Externí odkaz:
https://doaj.org/article/7fe3b2c0509d4510830a0c659c6d2f04
Autor:
Ravi K R Marreddy, Joao P C Pinto, Justina C Wolters, Eric R Geertsma, Fabrizia Fusetti, Hjalmar P Permentier, Oscar P Kuipers, Jan Kok, Bert Poolman
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e24060 (2011)
BACKGROUND: The biogenesis of membrane proteins is more complex than that of water-soluble proteins, and recombinant expression of membrane proteins in functional form and in amounts high enough for structural and functional studies is often problema
Externí odkaz:
https://doaj.org/article/a609a6e7bcc64012bdbedc2b49b62042