Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ravi K. R. Kalathur"'
Autor:
Ruize Gao, David Buechel, Ravi K. R. Kalathur, Marco F. Morini, Mairene Coto-Llerena, Caner Ercan, Salvatore Piscuoglio, Qian Chen, Tanja Blumer, Xueya Wang, Eva Dazert, Markus H. Heim, Michael N. Hall, Fengyuan Tang, Gerhard Christofori
Publikováno v:
Oncogenesis, Vol 10, Iss 7, Pp 1-13 (2021)
Abstract Understanding the mechanisms underlying evasive resistance in cancer is an unmet medical need to improve the efficacy of current therapies. In hepatocellular carcinoma (HCC), aberrant expression of hypoxia-inducible factor 1 α (HIF1α) and
Externí odkaz:
https://doaj.org/article/e03d208eef10428d9173423f817695c2
Autor:
Fengyuan Tang, Ruize Gao, Beena Jeevan-Raj, Christof B. Wyss, Ravi K. R. Kalathur, Salvatore Piscuoglio, Charlotte K. Y. Ng, Sravanth K. Hindupur, Sandro Nuciforo, Eva Dazert, Thomas Bock, Shuang Song, David Buechel, Marco F. Morini, Alexander Hergovich, Patrick Matthias, Dae-Sik Lim, Luigi M. Terracciano, Markus H. Heim, Michael N. Hall, Gerhard Christofori
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The autophagic and Hippo pathways are both well characterized contributors to cancer. Here, Tang et al show that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophagy induced by sor
Externí odkaz:
https://doaj.org/article/1bd4d7c4bf134f42b2b569c6511ab4d1
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis
Autor:
Ruize Gao, Ravi K R Kalathur, Mairene Coto‐Llerena, Caner Ercan, David Buechel, Song Shuang, Salvatore Piscuoglio, Michael T Dill, Fernando D Camargo, Gerhard Christofori, Fengyuan Tang
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 12, Pp 1-20 (2021)
Abstract Understanding the mechanisms underlying evasive resistance in cancer is an unmet medical need to improve the efficacy of current therapies. In this study, a combination of shRNA‐mediated synthetic lethality screening and transcriptomic ana
Externí odkaz:
https://doaj.org/article/0a45c210533448afa645988d3bfff73d
Publikováno v:
Nature Precedings
Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown. One potential mechanism co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______984::b356f561757fc3f01ada170fca44ed40
