Výsledky vyhledávání - "Ravi K. Deevi"

Akademický článek

PTEN Phosphatase-Independent Maintenance of Glandular Morphology in a Predictive Colorectal Cancer Model System

Autor: Ishaan C. Jagan, Ravi K. Deevi, Aliya Fatehullah, Rebecca Topley, Joshua Eves, Michael Stevenson, Maurice Loughrey, Kenneth Arthur, Frederick Charles Campbell

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 11, Pp 1218-1230 (2013)

Organotypic models may provide mechanistic insight into colorectal cancer (CRC) morphology. Three-dimensional (3D) colorectal gland formation is regulated by phosphatase and tensin homologue deleted on chromosome 10 (PTEN) coupling of cell division c

Externí odkaz: https://doaj.org/article/2e2f25e5e4204dee876d1983f91d5cea

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PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex

Autor: Frederick Charles Campbell, Arman Javadi, Mark G.H. Scott, Ravi K. Deevi, Emma Evergren, George S. Baillie, Elodie Blondel-Tepaz

Publikováno v: eLife, Vol 6 (2017)
eLife

PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signaling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05dafaf6d036388b0211d1d7da31a96
https://eprints.gla.ac.uk/144649/1/144649.pdf

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PTEN Phosphatase-Independent Maintenance of Glandular Morphology in a Predictive Colorectal Cancer Model System

Autor: Frederick Charles Campbell, Maurice B Loughrey, Kenneth Arthur, Joshua Eves, Michael Stevenson, Rebecca Topley, I. Jagan, Aliya Fatehullah, Ravi K. Deevi

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 11, Pp 1218-1230 (2013)
Jagan, I C, Deevi, R K, Fatehullah, A, Rebecca, T, Joshua, E, Michael, S, Loughrey, M, Arthur, K & Campbell, F 2013, ' PTEN Phosphatase-Independent Maintenance of Glandular Morphology in a Predictive Colorectal Cancer Model System ', Neoplasia, vol. 15, no. 11, pp. 1218-1230 . https://doi.org/10.1593/neo.121516

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b9c53d23b05643469533efae10042a
http://www.sciencedirect.com/science/article/pii/S1476558613800838

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Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype

Autor: Ravi K, Deevi, Jane, McClements, Karen D, McCloskey, Aliya, Fatehullah, Dorota, Tkocz, Arman, Javadi, Robyn, Higginson, Victoria, Marsh Durban, Marnix, Jansen, Alan, Clarke, Maurice B, Loughrey, Frederick C, Campbell

Publikováno v: Oncotarget

Development of cribriform morphology (CM) heralds malignant change in human colon but lack of mechanistic understanding hampers preventive therapy. This study investigated CM pathobiology in three-dimensional (3D) Caco-2 culture models of colorectal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::122d9eb0f9f13c0195a3ad41b84113ff
https://pubmed.ncbi.nlm.nih.gov/27119498

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PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling

Autor: Victoria Bingham, I. Jagan, Aliya Fatehullah, Frederick Charles Campbell, M. Nagaraju, Ravi K. Deevi

Publikováno v: British Journal of Cancer

Background: Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) regulation of the Rho-like GTPase Cdc42 has a central role in epithelial polarised growth, but effects of this molecular network on apoptosis remain unclear. Methods: To inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feacdd967619fd22fc2aafdc4e651aaf
http://europepmc.org/articles/PMC3241554

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Exchange protein directly activated by cAMP 1 (Epac1) is expressed in human neutrophils and mediates cAMP-dependent activation of the monomeric GTPase Rap1

Autor: Ravi K. Deevi, Cheryl McFarlane, Madhuri Dash-Koney, Karim Dib

Publikováno v: Journal of Leukocyte Biology. 90:741-749

Epac1 and Epac2 bind cAMP and mediate cAMP-dependent activation of Rap1. cAMP is produced in neutrophils in response to many chemoattractants. This second messenger plays a key role in the regulation of the functions of neutrophils. However, it is st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8940039312bf760392123f54b9bcb9db
https://doi.org/10.1189/jlb.0211108

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Nitric Oxide Produced in Response to Engagement of β2 Integrins on Human Neutrophils Activates the Monomeric GTPases Rap1 and Rap2 and Promotes Adhesion

Autor: Tommy Andersson, Karim Dib, Lena Axelsson, Catherine Adams, Veronika Jenei, Ravi K. Deevi, David G. Hirst

Publikováno v: Journal of Biological Chemistry. 281:35008-35020

We found that engagement of beta2 integrins on human neutrophils increased the levels of GTP-bound Rap1 and Rap2. Also, the activation of Rap1 was blocked by PP1, SU6656, LY294002, GF109203X, or BAPTA-AM, which indicates that the downstream signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef344eeded8957b4172916f348eff54
https://doi.org/10.1074/jbc.m601335200

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Rescue of glandular dysmorphogenesis in PTEN-deficient colorectal cancer epithelium by PPARγ-targeted therapy

Autor: I. Jagan, Frederick Charles Campbell, Victoria Bingham, Ravi K. Deevi, Aliya Fatehullah

Publikováno v: Oncogene. 32(10)

Disruption of glandular architecture associates with poor clinical outcome in high-grade colorectal cancer (CRC). Phosphatase and tensin homolog deleted on chromosome ten (PTEN) regulates morphogenic growth of benign MDCK (Madin Darby Canine Kidney)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480e1ce00fc54db16fcbb78a0ba64eda
https://pubmed.ncbi.nlm.nih.gov/22543585

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Enhanced lymphocyte interferon (IFN)-γ responses in a PTEN mutation-negative Cowden disease kindred

Autor: Ravi K. Deevi, R. Stevenson, P. J. Morrison, R. Stewart, Victoria Bingham, I. Dimmick, A. E. Irvine, I. Jagan, Marilyn A. Armstrong, Frederick Charles Campbell, Aliya Fatehullah

Summary Identification of immune modifiers of inherited cancer syndromes may provide a rationale for preventive therapy. Cowden disease (CD) is a genetically heterogeneous inherited cancer syndrome that arises predominantly from germline phosphatase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b0ee25ef53ab60b9ed5ba35d1fdffd
https://europepmc.org/articles/PMC3087912/

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