Genome-wide association study identifies four pan-ancestry loci for suicidal ideation in the Million Veteran Program.

Autor: Allison E Ashley-Koch, Nathan A Kimbrel, Xue J Qin, Jennifer H Lindquist, Melanie E Garrett, Michelle F Dennis, Lauren P Hair, Jennifer E Huffman, Daniel A Jacobson, Ravi K Madduri, Hilary Coon, Anna R Docherty, Jooeun Kang, Niamh Mullins, Douglas M Ruderfer, VA Million Veteran Program (MVP), MVP Suicide Exemplar Workgroup, International Suicide Genetics Consortium, Philip D Harvey, Benjamin H McMahon, David W Oslin, Elizabeth R Hauser, Michael A Hauser, Jean C Beckham

Publikováno v: PLoS Genetics, Vol 19, Iss 3, p e1010623 (2023)

Suicidal ideation (SI) often precedes and predicts suicide attempt and death, is the most common suicidal phenotype and is over-represented in veterans. The genetic architecture of SI in the absence of suicide attempt (SA) is unknown, yet believed to

Externí odkaz: https://doaj.org/article/4d6850e6746b413a90e0435fdd0699ad

The Case for Optimized Edge-Centric Tractography at Scale

Autor: Joseph Y. Moon, Pratik Mukherjee, Ravi K. Madduri, Amy J. Markowitz, Lanya T. Cai, Eva M. Palacios, Geoffrey T. Manley, Peer-Timo Bremer

Publikováno v: Frontiers in Neuroinformatics, Vol 16 (2022)

The anatomic validity of structural connectomes remains a significant uncertainty in neuroimaging. Edge-centric tractography reconstructs streamlines in bundles between each pair of cortical or subcortical regions. Although edge bundles provides a st

Externí odkaz: https://doaj.org/article/42c14f1ab570427086f5ff977a995ab4

Cardiovascular Disease Risk Assessment Using Traditional Risk Factors and Polygenic Risk Scores in the Million Veteran Program

Autor: Jason L. Vassy, Daniel C. Posner, Yuk-Lam Ho, David R. Gagnon, Ashley Galloway, Vidisha Tanukonda, Serena C. Houghton, Ravi K. Madduri, Benjamin H. McMahon, Philip S. Tsao, Scott M. Damrauer, Christopher J. O’Donnell, Themistocles L. Assimes, Juan P. Casas, J. Michael Gaziano, Michael J. Pencina, Yan V. Sun, Kelly Cho, Peter W.F. Wilson

Publikováno v: JAMA Cardiology.

ImportancePrimary prevention of atherosclerotic cardiovascular disease (ASCVD) relies on risk stratification. Genome-wide polygenic risk scores (PRSs) are proposed to improve ASCVD risk estimation.ObjectiveTo determine whether genome-wide PRSs for co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2067db67c090b71dc3e441ba129657b
https://doi.org/10.1001/jamacardio.2023.0857

Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry

Autor: Fei Chen, Ravi K. Madduri, Alex A. Rodriguez, Burcu F. Darst, Alisha Chou, Xin Sheng, Anqi Wang, Jiayi Shen, Edward J. Saunders, Suhn K. Rhie, Jeannette T. Bensen, Sue A. Ingles, Rick A. Kittles, Sara S. Strom, Benjamin A. Rybicki, Barbara Nemesure, William B. Isaacs, Janet L. Stanford, Wei Zheng, Maureen Sanderson, Esther M. John, Jong Y. Park, Jianfeng Xu, Ying Wang, Sonja I. Berndt, Chad D. Huff, Edward D. Yeboah, Yao Tettey, Joseph Lachance, Wei Tang, Christopher T. Rentsch, Kelly Cho, Benjamin H. Mcmahon, Richard B. Biritwum, Andrew A. Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Dana C. Crawford, Alpa V. Patel, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine M. Neslund-Dudas, Mariana C. Stern, Zsofia Kote-Jarai, Koveela Govindasami, Michael B. Cook, Anand P. Chokkalingam, Ann W. Hsing, Phyllis J. Goodman, Thomas J. Hoffmann, Bettina F. Drake, Jennifer J. Hu, Jacob M. Keaton, Jacklyn N. Hellwege, Peter E. Clark, Mohamed Jalloh, Serigne M. Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael O. Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen I. Aisuodionoe-Shadrach, Hafees O. Ajibola, Mustapha A. Jamda, Olabode P. Oluwole, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, James E. Mensah, Halimatou Diop, Stephen K. Van Den Eeden, Pascal Blanchet, Jay H. Fowke, Graham Casey, Anselm J. Hennis, Alexander Lubwama, Ian M. Thompson, Robin Leach, Douglas F. Easton, Michael H. Preuss, Ruth J. Loos, Susan M. Gundell, Peggy Wan, James L. Mohler, Elizabeth T. Fontham, Gary J. Smith, Jack A. Taylor, Shiv Srivastava, Rosaline A. Eeles, John D. Carpten, Adam S. Kibel, Luc Multigner, Marie-Élise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Eric A. Klein, Caroline Andrews, Timothy R. Rebbeck, Laurent Brureau, Stefan Ambs, Todd L. Edwards, Stephen Watya, Stephen J. Chanock, John S. Witte, William J. Blot, J. Michael Gaziano, Amy C. Justice, David V. Conti, Christopher A. Haiman

Publikováno v: European Urology
European Urology, 2023, 84 (1), pp.13-21. ⟨10.1016/j.eururo.2023.01.022⟩

Background: Genetic factors play an important role in prostate cancer (PCa) susceptibility.Objective: To discover common genetic variants contributing to the risk of PCa in men of African ancestry.Design, setting, and participants: We conducted a met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b42ff56b071fb413155ed348022ab4c
https://doi.org/10.1016/j.eururo.2023.01.022

Author response: Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations

Autor: Burcu F Darst, Fei Chen, Ravi K Madduri, Alex A Rodriguez, Xin Sheng, Christopher T Rentsch, Caroline Andrews, Wei Tang, Adam S Kibel, Anna Plym, Kelly Cho, Mohamed Jalloh, Serigne Magueye Gueye, Lamine Niang, Olufemi J Ogunbiyi, Olufemi Popoola, Akindele O Adebiyi, Oseremen I Aisuodionoe-Shadrach, Hafees O Ajibola, Mustapha A Jamda, Olabode P Oluwole, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, James E Mensah, Andrew Anthony Adjei, Halimatou Diop, Joseph Lachance, Timothy R Rebbeck, Stefan Ambs, J Michael Gaziano, Amy C Justice, David V Conti, Christopher A Haiman

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::593bc18632f6a18e206b35c10aa26bdc
https://doi.org/10.7554/elife.78304.sa2