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Data from Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules

Autor: Mary Ann Jordan, Ravi Chari, Wayne Widdison, Sharon Wilhelm, Leslie Wilson, Emin Oroudjev, Manu Lopus

Maytansine is a potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations. However, its side effects and lack of tumor specificity have prevented successful clinical use. Recently, antibody-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1878131ea284ab547cda39a80869f7b
https://doi.org/10.1158/1535-7163.c.6536337.v1

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Optimizing energy expenditure and oxygenation toward ventilator tolerance is associated with lower ventilator and intensive care unit days

Autor: Darwin Ang, Winston T. Richards, Jason Clark, Alejandro Garcia, Ravi Chari, Carrie Watson, Dinah Donaldson, Jason Farrah, Ted Alderman, Huazhi Liu, Jason Barde, Joshua Hagan

Publikováno v: The journal of trauma and acute care surgery. 87(3)

Background We hypothesize that if both energy expenditure and oxygenation are optimized (EEOO) toward ventilator tolerance, this would provide patients with the best condition to be liberated from the ventilator. We defined ventilator tolerance as ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4da3859cb1c5e3b7aa53286e6fbcbe3
https://pubmed.ncbi.nlm.nih.gov/31205210

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Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β

Autor: Sahana Bose, Dominic J. Ambrosi, Tariq Ghayur, Rajesh V. Kamath, Chung-Ming Hsieh, Susan E. Lacy, Donna Conlon, Chengbin Wu, Edit Tarcsa, Ravi Chari, Renee Miller

Publikováno v: mAbs

Interleukin-1 (IL-1) cytokines such as IL-1α, IL-1β, and IL-1Ra contribute to immune regulation and inflammatory processes by exerting a wide range of cellular responses, including expression of cytokines and chemokines, matrix metalloproteinases,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a1fc963afff0b5e92e916a67d46a9f
https://doi.org/10.1080/19420862.2015.1026501

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Abstract 538: LC-MS based catabolite identification study of an ADC with DM21-C, a novel maytansinoid linker-payload

Autor: Janet Lau, Paulin Salomon, Kerstin Sinkevicius, Juliet Costoplus, Megan Fuller, Raymond Xu, Stuart Hicks, Ravi Chari, Wayne Widdison, Nicholas Yoder, Thomas Keating

Publikováno v: Cancer Research. 79:538-538

ImmunoGen’s newest antibody-drug conjugate (ADC) design uses the novel maytansinoid linker-payload, DM21-C that bears a peptidase/protease cleavable linker. These ADCs show good bystander killing of proximal antigen negative cells, suggesting the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebf361db0b661d78f9beb98cf12786f9
https://doi.org/10.1158/1538-7445.am2019-538

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Determination of the dipole moments of RNAse SA wild type and a basic mutant

Autor: Shubhadra N. Singh, Sandeep Yadav, Devendra S. Kalonia, Ravi Chari, David N. Brems

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 80:1041-1052

In this study, we report the effects of acidic to basic residue point mutations (5K) on the dipole moment of RNAse SA at different pHs. Dipole moments were determined by measuring solution capacitance of the wild type (WT) and the 5K mutant with an i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f652ccbdfc50d57c10f8a9bc9131d6fa
https://doi.org/10.1002/prot.24006

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Modulation of the thermodynamic stability of proteins by polyols: Significance of polyol hydrophobicity and impact on the chemical potential of water

Autor: Vineet Kumar, Ravi Chari, Vikas K. Sharma, Devendra S. Kalonia

Publikováno v: International Journal of Pharmaceutics. 413:19-28

The exact mechanism of the modulation of chemical potential of proteins by polyols is not yet well understood. Present study investigates the role of hydrophobicity of polyols, and their impact on water activity and/or surface tension, in determining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64be971bc2caa26fde98564c5778b38f
https://doi.org/10.1016/j.ijpharm.2011.04.011

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Development of Improved Empirical Models for Estimating the Binding Constant of a β-Cyclodextrin Inclusion Complex

Autor: Farooq Qureshi, Ralph Tarantino, Devendra S. Kalonia, Ravi Chari, John Moschera

Publikováno v: Pharmaceutical Research. 26:161-171

To develop empirical models for predicting the binding between a drug and beta-cyclodextrin. Specifically, the logarithm of the 1:1 binding constant is expressed as the function of various molecular descriptors of the drug. Many potential drugs exhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0078920a2c19d4d9dad78f114a654f8
https://doi.org/10.1007/s11095-008-9733-x

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