Zobrazeno 1 - 10
of 900
pro vyhledávání: '"Ravi, Salgia"'
Autor:
B. Madhu Krishna, Pankaj Garg, Sravani Ramisetty, Ayalur Raghu Subbalakshmi, Prakash Kulkarni, Ravi Salgia, Sharad S. Singhal
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Cancer ranks as the second leading cause of mortality worldwide, prompting extensive investigations into factors contributing to its development. Among these factors, genetic variations, known as genotypic polymorphisms, have been identified
Externí odkaz:
https://doaj.org/article/0d99d8963d68446895dae769be7a8ec6
Autor:
Dan Zhao, Haiqing Li, Isa Mambetsariev, Tamara Mirzapoiazova, Chen Chen, Jeremy Fricke, Deric Wheeler, Leonidas Arvanitis, Raju Pillai, Michelle Afkhami, Bihong T. Chen, Martin Sattler, Loretta Erhunmwunsee, Erminia Massarelli, Prakash Kulkarni, Arya Amini, Brian Armstrong, Ravi Salgia
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract We conducted spatial immune tumor microenvironment (iTME) profiling using formalin-fixed paraffin-embedded (FFPE) samples of 25 KRAS-mutated non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs), includ
Externí odkaz:
https://doaj.org/article/84e066ed9cad48ee852f6917439d4ae5
Autor:
Erminia Massarelli, Ravi Salgia, Diana Bell, Haiqing Li, Arya Amini, Sue Chang, Atish Mohanty, Michelle Afkhami, Amanda Reyes, Rebecca Pharaon, Holly Yin, Dana Do, Arin Nam, Thomas Gernon, Robert Kang, Sagus Sampath, Prakash Kulkarni, Raju Pillai, Vicky Villaflor, Ellie Maghami
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background The study summarizes the potential use of immunotherapy for BRAF-mutated papillary thyroid cancer (PTC) by analyzing the immune profile of City of Hope PTC patient samples and comparing them to the thyroid dataset available in the TCGA dat
Externí odkaz:
https://doaj.org/article/f8577052c6e344559c40dcdf83560db4
Autor:
Tamara Mirzapoiazova, Liz Tseng, Bolot Mambetsariev, Haiqing Li, Chih-Hong Lou, Alex Pozhitkov, Sravani Keerthi Ramisetty, Sangkil Nam, Isa Mambetsariev, Brian Armstrong, Jyoti Malhotra, Leonidas Arvanitis, Mohd Wasim Nasser, Surinder K. Batra, Steven T. Rosen, Deric L. Wheeler, Sharad S. Singhal, Prakash Kulkarni, Ravi Salgia
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110132- (2024)
Summary: Although up to 80% small cell lung cancer (SCLC) patients’ response is good for first-line chemotherapy regimen, most patients develop recurrence of the disease within weeks to months. Here, we report cytostatic effect of leflunomide (Lefl
Externí odkaz:
https://doaj.org/article/c1d2afcf8682490aa1a6bb5963b1e1f1
Autor:
Prakash Kulkarni, Ravi Salgia
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109308- (2024)
Organisms as well as cancer cells are adept at adapting to changes in the environment in which they find themselves, by actively adjusting their phenotype. Phenotypic plasticity is a quantitative trait that confers a fitness advantage to the organism
Externí odkaz:
https://doaj.org/article/24a7b2a36d184330acccbd3d2b622287
Autor:
Ashu Shah, Sanjib Chaudhary, Imayavaramban Lakshmanan, Abhijit Aithal, Sophia G. Kisling, Claire Sorrell, Saravanakumar Marimuthu, Shailendra K. Gautam, Sanchita Rauth, Prakash Kshirsagar, Jesse L. Cox, Gopalakrishnan Natarajan, Rakesh Bhatia, Kavita Mallya, Satyanarayana Rachagani, Mohd Wasim Nasser, Apar Kishor Ganti, Ravi Salgia, Sushil Kumar, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-16 (2023)
Abstract Aberrantly expressed onco-mucin 16 (MUC16) and its post-cleavage generated surface tethered carboxy-terminal (MUC16-Cter) domain are strongly associated with poor prognosis and lethality of pancreatic (PC) and non-small cell lung cancer (NSC
Externí odkaz:
https://doaj.org/article/32f677e6e7f342b1a84bc4cad2938d3b
Autor:
Mari Iida, Bridget E. Crossman, Kourtney L. Kostecki, Christine E. Glitchev, Carlene A. Kranjac, Madisen T. Crow, Jillian M. Adams, Peng Liu, Irene Ong, David T. Yang, Irene Kang, Ravi Salgia, Deric L. Wheeler
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5109 (2024)
Triple-negative breast cancer (TNBC) is characterized by the absence of the estrogen receptor, progesterone receptor, and receptor tyrosine kinase HER2 expression. Due to the limited number of FDA-approved targeted therapies for TNBC, there is an ong
Externí odkaz:
https://doaj.org/article/fca3a4f3de7e457ab929080d8b2d80aa
Autor:
Linlin Guo, Atish Mohanty, Sharad Singhal, Saumya Srivastava, Arin Nam, Charles Warden, Sravani Ramisetty, Yate-Ching Yuan, Hyejin Cho, Xiwei Wu, Aimin Li, Manik Vohra, Srinivas Vinod Saladi, Deric Wheeler, Leonidas Arvanitis, Erminia Massarelli, Prakash Kulkarni, Yiming Zeng, Ravi Salgia
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107302- (2023)
Summary: This study investigates the role of integrin β4 (ITGB4) and stemness-associated factor SOX2 in platinum resistance in lung squamous cell carcinoma (LUSC). The expression of SOX2 and ITGB4 is found to be high in all LUSC subtypes, but the im
Externí odkaz:
https://doaj.org/article/9962e7214592483093812b263a3e559e
Autor:
Parvez Khan, Jawed Akhtar Siddiqui, Prakash G. Kshirsagar, Ramakanth Chirravuri Venkata, Shailendra Kumar Maurya, Tamara Mirzapoiazova, Naveenkumar Perumal, Sanjib Chaudhary, Ranjana Kumari Kanchan, Mahek Fatima, Md Arafat Khan, Asad Ur Rehman, Imayavaramban Lakshmanan, Sidharth Mahapatra, Geoffrey A. Talmon, Prakash Kulkarni, Apar K. Ganti, Maneesh Jain, Ravi Salgia, Surinder Kumar Batra, Mohd Wasim Nasser
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-22 (2023)
Abstract Background Small cell lung cancer (SCLC) is an aggressive lung cancer subtype that is associated with high recurrence and poor prognosis. Due to lack of potential drug targets, SCLC patients have few therapeutic options. MicroRNAs (miRNAs) p
Externí odkaz:
https://doaj.org/article/70ed0bb8d596449cab613722670a3e36
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107109- (2023)
Summary: Phenotypic plasticity is the ability of individual genotypes to produce different phenotypes in response to environmental perturbations. We previously postulated how conformational noise emanating from conformational dynamics of intrinsicall
Externí odkaz:
https://doaj.org/article/5ca00f8850624a748dcf6d4d73ff5d6e