Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Ravi, Rajagopalan"'
Publikováno v:
Journal of Hepatology. 77:S464
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e85dbb3f46f31cea26b8b4239936adc8
https://doi.org/10.1016/s0168-8278(22)01258-2
https://doi.org/10.1016/s0168-8278(22)01258-2
Autor:
Jeremy Fournier, Karen Chen, Artur K. Mailyan, Jeffrey J. Jackson, Brad O. Buckman, Kumar Emayan, Shendong Yuan, Ravi Rajagopalan, Shawn Misialek, Marc Adler, Michael Blaesse, Andreas Griessner, Armen Zakarian
Publikováno v:
Organic letters. 21(2)
A total synthesis of N-desmethyl thalassospiramide C, a unique strained macrocyclic proteobacterial depsipeptide, enabled a detailed crystallographic study of its covalent complex with cathepsin K, a member of a medicinally important family of cystei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224f7ef009372f080fe122a19b962fd5
https://pubmed.ncbi.nlm.nih.gov/30628449
https://pubmed.ncbi.nlm.nih.gov/30628449
Autor:
Scott D. Seiwert, Karl Kossen, John B. Nicholas, Jyanwei Liu, Caralee Schaefer, Brad O. Buckman, Lea Huang, Donald Ruhrmund, Sharlene Lim, Lisa Hooi, Leonid Beigelman, Lin Pan, Vladimir Serebryany, Sarah K. Stevens, Srikonda Sastry, Shawn Misialek, Sophia Yap, Ravi Rajagopalan, Natalia Aleskovski
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
The current paradigm for the treatment of chronic hepatitis C virus (HCV) infection involves combinations of agents that act directly on steps of the HCV life cycle. Here we report the preclinical characteristics of ITMN-8187, a nonmacrocyclic inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e526d623aa25a82e039d51bfe79da1d8
https://doi.org/10.1128/aac.01569-16
https://doi.org/10.1128/aac.01569-16
Publikováno v:
In Analytical Biochemistry 10 September 1999 273(2):298-304
Autor:
Huiyong Hu, Barry Patrick Hart, Roopa Rai, Michael J. Green, Ravi Rajagopalan, Yu M. Xia, Joseph D. Ho, John R. Somoza, Isabelle Lehoux, Dange Vijay Kumar, Jennifer Riggs, Ken A. Brameld, James W. Janc, Tony Ton, Wendy B. Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:300-304
The discovery and optimization of a novel class of quinolone small-molecules that inhibit NS5B polymerase, a key enzyme of the HCV viral life-cycle, is described. Our research led to the replacement of a hydrolytically labile ester functionality with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3593c853fb618014eb009af3250b00b8
https://doi.org/10.1016/j.bmcl.2011.11.013
https://doi.org/10.1016/j.bmcl.2011.11.013
Autor:
Antitsa Dimitrova Stoycheva, Leonid Beigelman, Karl Kossen, P. T. Ravi Rajagopalan, Donald Ruhrmund, Guangyi Wang, Brunella Felicetti, Colin H. MacKinnon, Scott D. Seiwert, Christian A.G.N. Montalbetti, Brad O. Buckman, Debasis Das, Dorian Leo Schönfeld, Huoxing Lei, Thomas Stephen Coulter, John Barker, Jian Hong, Shawn Misialek, Lisa Hooi, Sarah E. Bailey, Xinjie Gai, Wang Xiaofang, Robert K. Y. Cheng, Richard John Mears
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4480-4483
(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000ef0a9262fe818849b255d0368b7bd
https://doi.org/10.1016/j.bmcl.2009.05.022
https://doi.org/10.1016/j.bmcl.2009.05.022
Autor:
Jin Hong, Christine Lemieux, Scott D. Seiwert, Shawn Misialek, Robert Rieger, Dylan P. Hartley, Lawrence M. Blatt, Sharlene R. Lim, Kevin Ronald Condroski, Antitsa Dimitrova Stoycheva, Lin Pan, Hua Tan, Gary P. Hingorani, Leonid Beigelman, Hailong Zhang, John A. Josey, Xiaoli Qin, Karl Kossen, P. T. Ravi Rajagopalan, Mary Geck Do, Vladimir Serebryany, Sarah K. Stevens, Andrews Steven W, Jiang Yutong
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:4432-4441
Future treatments for chronic hepatitis C virus (HCV) infection are likely to include agents that target viral components directly. Here, the preclinical characteristics of ITMN-191, a peptidomimetic inhibitor of the NS3/4A protease of HCV, are descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9981ec4b6c65bf78b0076564bdd6d18a
https://doi.org/10.1128/aac.00699-08
https://doi.org/10.1128/aac.00699-08
Autor:
M. R. K. Alley, † Youn-Hi Woo, Tsutomu Akama, and Ali Tavassoli, Justin Baboval, P. T. Ravi Rajagopalan, Stephen J. Baker, Lucy Shapiro, Lyn Sue Kahng, Yong-Kang Zhang, Stephen J. Benkovic, Weimin Mao, Mark Wall
Publikováno v:
Journal of Medicinal Chemistry. 48:7468-7476
As bacteria continue to develop resistance toward current antibiotics, we find ourselves in a continual battle to identify new antibacterial agents and targets. We report herein a class of boron-containing compounds termed borinic esters that have br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b191b0831381fde56db4b447476bd3
https://doi.org/10.1021/jm050676a
https://doi.org/10.1021/jm050676a
Publikováno v:
Analytical Biochemistry. 340:336-340
We have developed a nonradioactive assay method for DNA methyltransferases based on the ability to protect substrate DNA from restriction. DNA immobilized to a microplate well was treated sequentially with methyltransferase and an appropriate endonuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce4266744afc168768523841ddb835d
https://doi.org/10.1016/j.ab.2005.01.059
https://doi.org/10.1016/j.ab.2005.01.059
Publikováno v:
Proceedings of the National Academy of Sciences. 101:2764-2769
The interaction of dihydrofolate (H 2 F) and NADPH with a fluorescent derivative of H 2 F reductase (DHFR) was studied by using transient and single-molecule techniques. The fluorescent moiety Alexa 488 was attached to the structural loop that closes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08693ad550ca9745c7546b71a1f61be4
https://doi.org/10.1073/pnas.0400091101
https://doi.org/10.1073/pnas.0400091101