Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Ravi, R. Gnana"'
1
2-Chloro N 6 -methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate is a selective high affinity P2Y 1 receptor antagonist
Autor: Ravi, R. Gnana, Jacobson, Kenneth A., Boyer, José L., Harden, T. Kendall, Adams, Mary
1. We reported previously that bisphosphate derivatives of adenosine are antagonists of the P2Y(1) receptor and that modification of the ribose in these analogues is tolerated in the P2Y(1) receptor binding pharmacophore. 2. Here we delineate the pha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f51f55f63224ae9811784843e9d31471
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2
Methanocarba Modification of Uracil and Adenine Nucleotides: High Potency of Northern Ring Conformation at P2Y 1 , P2Y 2 , P2Y 4 , and P2Y 11 but Not P2Y 6 Receptors
Autor: Malmsjö, Malin, Jacobson, Kenneth A., Boyer, José L., Ravi, R. Gnana, Wihlborg, Anna-Karin, Erlinge, David, Marquez, Victor E., Maddileti, Savitri, Kim, Hak Sung, Harden, T. Kendall
The potency of nucleotide antagonists at P2Y1 receptors was enhanced by replacing the ribose moiety with a constrained carbocyclic ring (Nandanan, et al. J. Med. Chem. 2000, 43, 829—842). We have now synthesized ring-constrained methanocarba analog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ed9b8d2bdcdea8f232ee506e29d9d75
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3
Adenine Nucleotide Analogues Locked in a Northern Methanocarba Conformation: Enhanced Stability and Potency as P2Y 1 Receptor Agonists
Autor: Jacobson, Kenneth A., Maddileti, Savitri, Zimmermann, Herbert, Lee, Kyeong, Boyer, José L., Ravi, R. Gnana, Servos, Jörg, Kim, Hak Sung, Harden, T. Kendall
Preference for the Northern (N) ring conformation of the ribose moiety of nucleotide 5′-triphosphate agonists at P2Y1, P2Y2, P2Y4, and P2Y11 receptors, but not P2Y6 receptors, was established using a ring-constrained methanocarba (a 3.1.0-bicyclohe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a79e7fbe40bd50ad080ecf8b812a65e
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5
Akademický článek
2-Chloro N[sup6]-methyl-(N)-methanocarba-2'-deoxyadenosine-3', 5'-bisphophate is a selective high affinity P2Y[sub1] receptor antagonist.
Autor: Boyer, Jose L., Adams, Mary, Ravi, R. Gnana, Jacobson, Kenneth A., Harden, T. Kendall
Publikováno v: British Journal of Pharmacology; Apr2002, Vol. 135 Issue 8, p2004-2010, 7p, 1 Diagram, 5 Graphs
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6
Akademický článek
Potent P2X7 receptor antagonists: Tyrosyl derivatives synthesized using a sequential parallel synthetic approach.
Autor: Ravi, R. Gnana, Kertesy, Sylvia B., Dubyak, George R., Jacobson, Kenneth A.
Publikováno v: Drug Development Research; Oct2001, Vol. 54 Issue 2, p75-87, 13p
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7
Akademický článek
Asymmetric allylation and reduction on an ephedrine-derived template: Stereoselective synthesis...
Autor: Pansare, Sunil V., Ravi, R. Gnana, Jain, Rajendra P.
Publikováno v: Journal of Organic Chemistry; 06/12/98, Vol. 63 Issue 12, p4120, 5p, 4 Color Photographs, 1 Graph
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10
Akademický článek
Unprecedented Acceleration of Zirconium(IV)-Assisted Peptide Hydrolysis at Neutral pH.
Autor: Kassai, Miki, Ravi, R. Gnana, Shealy, Sarah J., Grant, Kathryn B.
Publikováno v: Inorganic Chemistry; 10/4/2004, Vol. 43 Issue 20, p6130-6132, 3p, 1 Diagram, 1 Chart
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