Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Ravi, R. Gnana"'
1
2-Chloro N 6 -methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate is a selective high affinity P2Y 1 receptor antagonist
Autor: Ravi, R. Gnana, Jacobson, Kenneth A., Boyer, José L., Harden, T. Kendall, Adams, Mary
1. We reported previously that bisphosphate derivatives of adenosine are antagonists of the P2Y(1) receptor and that modification of the ribose in these analogues is tolerated in the P2Y(1) receptor binding pharmacophore. 2. Here we delineate the pha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f51f55f63224ae9811784843e9d31471
Zobrazit plný text záznamu
2
Methanocarba Modification of Uracil and Adenine Nucleotides: High Potency of Northern Ring Conformation at P2Y 1 , P2Y 2 , P2Y 4 , and P2Y 11 but Not P2Y 6 Receptors
Autor: Malmsjö, Malin, Jacobson, Kenneth A., Boyer, José L., Ravi, R. Gnana, Wihlborg, Anna-Karin, Erlinge, David, Marquez, Victor E., Maddileti, Savitri, Kim, Hak Sung, Harden, T. Kendall
The potency of nucleotide antagonists at P2Y1 receptors was enhanced by replacing the ribose moiety with a constrained carbocyclic ring (Nandanan, et al. J. Med. Chem. 2000, 43, 829—842). We have now synthesized ring-constrained methanocarba analog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ed9b8d2bdcdea8f232ee506e29d9d75
Zobrazit plný text záznamu
3
Adenine Nucleotide Analogues Locked in a Northern Methanocarba Conformation: Enhanced Stability and Potency as P2Y 1 Receptor Agonists
Autor: Jacobson, Kenneth A., Maddileti, Savitri, Zimmermann, Herbert, Lee, Kyeong, Boyer, José L., Ravi, R. Gnana, Servos, Jörg, Kim, Hak Sung, Harden, T. Kendall
Preference for the Northern (N) ring conformation of the ribose moiety of nucleotide 5′-triphosphate agonists at P2Y1, P2Y2, P2Y4, and P2Y11 receptors, but not P2Y6 receptors, was established using a ring-constrained methanocarba (a 3.1.0-bicyclohe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a79e7fbe40bd50ad080ecf8b812a65e
Zobrazit plný text záznamu
5
Akademický článek
2-Chloro N[sup6]-methyl-(N)-methanocarba-2'-deoxyadenosine-3', 5'-bisphophate is a selective high affinity P2Y[sub1] receptor antagonist.
Autor: Boyer, Jose L., Adams, Mary, Ravi, R. Gnana, Jacobson, Kenneth A., Harden, T. Kendall
Publikováno v: British Journal of Pharmacology; Apr2002, Vol. 135 Issue 8, p2004-2010, 7p, 1 Diagram, 5 Graphs
Zobrazit plný text záznamu
6
Akademický článek
Potent P2X7 receptor antagonists: Tyrosyl derivatives synthesized using a sequential parallel synthetic approach.
Autor: Ravi, R. Gnana, Kertesy, Sylvia B., Dubyak, George R., Jacobson, Kenneth A.
Publikováno v: Drug Development Research; Oct2001, Vol. 54 Issue 2, p75-87, 13p
Zobrazit plný text záznamu
7
Akademický článek
Asymmetric allylation and reduction on an ephedrine-derived template: Stereoselective synthesis...
Autor: Pansare, Sunil V., Ravi, R. Gnana, Jain, Rajendra P.
Publikováno v: Journal of Organic Chemistry; 06/12/98, Vol. 63 Issue 12, p4120, 5p, 4 Color Photographs, 1 Graph
Zobrazit plný text záznamu
10
Akademický článek
Unprecedented Acceleration of Zirconium(IV)-Assisted Peptide Hydrolysis at Neutral pH.
Autor: Kassai, Miki, Ravi, R. Gnana, Shealy, Sarah J., Grant, Kathryn B.
Publikováno v: Inorganic Chemistry; 10/4/2004, Vol. 43 Issue 20, p6130-6132, 3p, 1 Diagram, 1 Chart
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje