Výsledky vyhledávání - "Ravi, Jalluri"

Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach

Publikováno v: ACS Medicinal Chemistry Letters. 14:312-318

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d69a138c9422a9fb256b43b29026ea0
https://doi.org/10.1021/acsmedchemlett.3c00003

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Supplemental Data from The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies

Supplemental Tables 1 & 2 Supplemental Figure Legends Supplemental Figures 1 - 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9cd1caeb5c5e06cfd8b05f86b576b1
https://doi.org/10.1158/1078-0432.22475952

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Data from The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies

Purpose:Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways; BET inhibitors have demonstrated activity in diverse models of hematologic and solid tumors. We report the preclinical c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67622e0fbfefceb9ea9cf87738b999fe
https://doi.org/10.1158/1078-0432.c.6529230.v1

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Discovery of a novel 2-spiroproline steroid mimetic scaffold for the potent inhibition of 11β-HSD1

Autor: David M. Burns, Chunhong He, Yun-Long Li, Jincong Zhuo, Ding-Quan Qian, Lihua Chen, Ravi Jalluri, Sharon Diamond, Maryanne B. Covington, Yanlong Li, Richard Wynn, Peggy Scherle, Swamy Yeleswaram, Gregory Hollis, Steve Friedman, Brian Metcalf, Wenqing Yao

Publikováno v: Bioorganicmedicinal chemistry letters. 73

11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been identified as the primary enzyme responsible for the activation of hepatic cortisone to cortisol in specific peripheral tissues, resulting in the concomitant antagonism of insulin action within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbafe40c80b68974928f2b0a5dbd9bd
https://pubmed.ncbi.nlm.nih.gov/35835377

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Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach

Publikováno v: SSRN Electronic Journal.

11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been identified as the primary enzyme responsible for the activation of hepatic cortisone to cortisol in specific peripheral tissues resulting in the concomitant antagonism of insulin action within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3692552a04b6f880ed62ecd30b202590
https://doi.org/10.2139/ssrn.4056120

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Abstract 167: Pre-clinical characterization of a novel series of FGFR2 selective inhibitors with potency against clinically relevant mutations

Autor: John Fischer, Karyn Bouhana, Mark J. Chicarelli, Josh Dahlke, Brad Fell, Jennifer Fulton, Anna Guarnieri, Ravi Jalluri, Amber Johnson, Brent Mclean, Max Mejia, Rob Rieger, John Robinson, Mareli Rodriguez, Francis Sullivan, Yang Wang, Shannon Winski, Yeyun Zhou

Publikováno v: Cancer Research. 82:167-167

The fibroblast growth factor receptor (FGFR) family of protein tyrosine kinases plays a role in many physiological processes including angiogenesis and wound healing. FGFR mutations, fusions, rearrangements, and amplifications have been linked to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d82e7b062a7d969a9dd69a8753ada94f
https://doi.org/10.1158/1538-7445.am2022-167

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