Výsledky vyhledávání - "Raven H. Huang"

Akademický článek

Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger

Autor: Shirin Fatma, Arpita Chakravarti, Xuankun Zeng, Raven H. Huang

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Many bacterial cyclic-oligonucleotide-based antiphage signaling systems (CBASS) employ effectors with SAVED domains. Here, the authors present a biochemical and structural characterization of two such CBASS, providing mechanistic insights into bacter

Externí odkaz: https://doaj.org/article/de1e461a293446d0a6357b4dd12aedbc

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Sequential rescue and repair of stalled and damaged ribosome by bacterial PrfH and RtcB

Autor: Fuxing Zeng, Qingrong Li, Yannan Tian, Adrika Raybarman, Raven H. Huang, Amy Carruthers, Shirin Fatma

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(29)

RtcB is involved in transfer RNA (tRNA) splicing in archaeal and eukaryotic organisms. However, most RtcBs are found in bacteria, whose tRNAs have no introns. Because tRNAs are the substrates of archaeal and eukaryotic RtcB, it is assumed that bacter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad95b775b56be6294ef2ca426a18da5c
https://pubmed.ncbi.nlm.nih.gov/35858322

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Reconstitution and substrate specificity for isopentenyl pyrophosphate of the antiviral radical SAM enzyme viperin

Autor: Arpita Chakravarti, Rezvan Shahoei, Hugo Lee, Shirin Fatma, Kiruthika Selvadurai, Emad Tajkhorshid, Raven H. Huang

Publikováno v: Journal of Biological Chemistry. 293:14122-14133

Viperin is a radical SAM enzyme that has been shown to possess antiviral activity against a broad spectrum of viruses; however, its molecular mechanism is unknown. We report here that recombinant fungal and archaeal viperin enzymes catalyze the addit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00792b60679a83495fd58afb48a6bd77
https://doi.org/10.1074/jbc.ra118.003998

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Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations

Autor: Cindy J. Castelle, Karthik Anantharaman, Raven H. Huang, Alexander J. Probst, Jillian F. Banfield, Christopher T. Brown

Publikováno v: Castelle, CJ; Brown, CT; Anantharaman, K; Probst, AJ; Huang, RH; & Banfield, JF. (2018). Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations. Nature Reviews Microbiology, 16(10), 629-645. doi: 10.1038/s41579-018-0076-2. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/4dz5g9x3
Nature reviews. Microbiology, vol 16, iss 10

© 2018, Springer Nature Limited. Candidate phyla radiation (CPR) bacteria and DPANN (an acronym of the names of the first included phyla) archaea are massive radiations of organisms that are widely distributed across Earth’s environments, yet we k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546e317f85a5f1e8ef1cdf5db2c307d9
http://www.escholarship.org/uc/item/4dz5g9x3

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Double methylation of tRNA-U54 to 2′-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7

Autor: Isabel Freund, Alexander H. Dalpke, Tatjana Eigenbrod, Guillaume Bec, Virginie Marchand, Raven H. Huang, Yuri Motorin, Patrick Keller, Mark Helm

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2018, 46 (18), pp.9764-9775. ⟨10.1093/nar/gky644⟩
Nucleic Acids Research, 2018, 46 (18), pp.9764-9775. ⟨10.1093/nar/gky644⟩

Sensing of nucleic acids for molecular discrimination between self and non-self is a challenging task for the innate immune system. RNA acts as a potent stimulus for pattern recognition receptors including in particular human Toll-like receptor 7 (TL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2936a22caa5e409afeb3d7e3499acbcf
https://hal.univ-lorraine.fr/hal-01864193

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Probing the substrate specificity of the bacterial Pnkp/Hen1 RNA repair system using synthetic RNAs

Autor: Pei Wang, Chio Mui Chan, Can Zhang, Raven H. Huang

Publikováno v: RNA. 18:335-344

Ribotoxins cleave essential RNAs involved in protein synthesis as a strategy for cell killing. RNA repair systems exist in nature to counteract the lethal actions of ribotoxins, as first demonstrated by the RNA repair system from bacteriophage T4 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5d53532d6582baf34a99c9de01a301
https://doi.org/10.1261/rna.030502.111

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Different Thermodynamic Binding Mechanisms and Peptide Fine Specificities Associated with a Panel of Structurally Similar High-Affinity T Cell Receptors

Autor: Yi-Gui Gao, Alexander J. Bankovich, Lindsay L. Jones, Raven H. Huang, Leremy A. Colf, David M. Kranz, Jennifer D. Stone, K.C Garcia, C.M Chan

Publikováno v: Biochemistry. 47:12398-12408

To understand the mechanisms that govern T cell receptor (TCR)-peptide MHC (pMHC) binding and the role that different regions of the TCR play in affinity and antigen specificity, we have studied the TCR from T cell clone 2C. High-affinity mutants of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14d6e0870c3544dfc62990586fdb934
https://doi.org/10.1021/bi801349g

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Crystallographic snapshots of eukaryotic dimethylallyltransferase acting on tRNA: Insight into tRNA recognition and reaction mechanism

Autor: Chun Zhou, Raven H. Huang

Publikováno v: Proceedings of the National Academy of Sciences. 105:16142-16147

Hypermodifications near the anticodon of tRNA are fundamental for the efficiency and fidelity of protein synthesis. Dimethylallyltransferase (DMATase) catalyzes transfer of a dimethylallyl moiety from dimethylallyl pyrophosphate to N6 of A37 in certa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629112ddf6a7cd1e4c1611dde0e69b10
https://doi.org/10.1073/pnas.0805680105

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Structure of tRNA Dimethylallyltransferase: RNA Modification through a Channel

Autor: Chun Zhou, Wei Xie, Raven H. Huang

Publikováno v: Journal of Molecular Biology. 367:872-881

Dimethylallyltransferase (DMATase) transfers a five-carbon isoprenoid moiety from dimethylallyl pyrophosphate (DMAPP) to the amino group of adenosine at position 37 of certain tRNAs. Reported here are the crystal structures of Pseudomonas aeruginosa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51be9bb5f25f285b915f7f01bd1a278b
https://doi.org/10.1016/j.jmb.2007.01.048

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Reconstitution and structure of a bacterial Pnkp1–Rnl–Hen1 RNA repair complex

Autor: Raven H. Huang, Pei Wang, Kiruthika Selvadurai

Publikováno v: Nature Communications

Ribotoxins cleave essential RNAs for cell killing, and RNA repair neutralizes the damage inflicted by ribotoxins for cell survival. Here we report a new bacterial RNA repair complex that performs RNA repair linked to immunity. This new RNA repair com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999b25d542bc8553208108dda4275db8
https://doi.org/10.1038/ncomms7876

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