Výsledky vyhledávání - "Ravel-Chapuis A"

Akademický článek

Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation

Autor: Alexis Osseni, Aymeric Ravel-Chapuis, Edwige Belotti, Isabella Scionti, Yann-Gaël Gangloff, Vincent Moncollin, Laetitia Mazelin, Remi Mounier, Pascal Leblanc, Bernard J. Jasmin, Laurent Schaeffer

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Here, authors show that Smad3 acetylation via HDAC6 inhibition reverses Duchenne muscular dystrophy-like symptoms in the mdx mouse model, suggesting a potential therapeutic target for the disorder.

Externí odkaz: https://doaj.org/article/cdf9d7e3e2ad4da9b5e4aa9491b771ee

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Akademický článek

Combinatorial therapies for rescuing myotonic dystrophy type 1 skeletal muscle defects

Autor: Ravel-Chapuis, Aymeric, Jasmin, Bernard J.

Publikováno v: In Trends in Molecular Medicine June 2022 28(6):439-442

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Akademický článek

Vorinostat Improves Myotonic Dystrophy Type 1 Splicing Abnormalities in DM1 Muscle Cell Lines and Skeletal Muscle from a DM1 Mouse Model.

Autor: Neault, Nafisa^1,2,3 (AUTHOR), Ravel-Chapuis, Aymeric^2,3,4 (AUTHOR), Baird, Stephen D.¹ (AUTHOR), Lunde, John A.^2,3 (AUTHOR), Poirier, Mathieu¹ (AUTHOR), Staykov, Emiliyan¹ (AUTHOR), Plaza-Diaz, Julio^1,5,6 (AUTHOR), Medina, Gerardo¹ (AUTHOR), Abadía-Molina, Francisco^7,8 (AUTHOR), Jasmin, Bernard J.^2,3 (AUTHOR), MacKenzie, Alex E.^1,2,3 (AUTHOR) mackenzie@cheo.on.ca

Publikováno v: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p3794. 24p.

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Akademický článek

AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency

Autor: Jennifer Karmouch, Perrine Delers, Fannie Semprez, Nouha Soyed, Julie Areias, Guy Bélanger, Aymeric Ravel-Chapuis, Alexandre Dobbertin, Bernard J. Jasmin, Claire Legay

Publikováno v: Frontiers in Molecular Neuroscience, Vol 13 (2020)

Collagen Q (COLQ) is a specific collagen that anchors acetylcholinesterase (AChE) in the synaptic cleft of the neuromuscular junction. So far, no mutation has been identified in the ACHE human gene but over 50 different mutations in the COLQ gene are

Externí odkaz: https://doaj.org/article/d01ca21843fd4ff3a761d1c86a17dfbd

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Akademický článek

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Vorinostat Improves Myotonic Dystrophy Type 1 Splicing Abnormalities in DM1 Muscle Cell Lines and Skeletal Muscle from a DM1 Mouse Model

Autor: Nafisa Neault, Aymeric Ravel-Chapuis, Stephen D. Baird, John A. Lunde, Mathieu Poirier, Emiliyan Staykov, Julio Plaza-Diaz, Gerardo Medina, Francisco Abadía-Molina, Bernard J. Jasmin, Alex E. MacKenzie

Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3794

Myotonic dystrophy type 1 (DM1), the most common form of adult muscular dystrophy, is caused by an abnormal expansion of CTG repeats in the 30 untranslated region of the dystrophia myotonica protein kinase (DMPK) gene. The expanded repeats of the DMP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe0e4a73289fd91013ac9d328e1153b
https://hdl.handle.net/10481/80893

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A novel CARM1–HuR axis involved in muscle differentiation and plasticity misregulated in spinal muscular atrophy

Autor: Jocelyn Côté, Bernard J. Jasmin, Aymeric Ravel-Chapuis, Amir Haghandish, Nasibeh Daneshvar

Publikováno v: Human Molecular Genetics. 31:1453-1470

Spinal muscular atrophy (SMA) is characterized by the loss of alpha motor neurons in the spinal cord and a progressive muscle weakness and atrophy. SMA is caused by loss-of-function mutations and/or deletions in the survival of motor neuron (SMN) gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e567b732c5a33544b651cade1bd931a9
https://doi.org/10.1093/hmg/ddab333

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