Výsledky vyhledávání - "Ravel-Chapuis A"

Akademický článek

The AMPK allosteric activator MK-8722 improves the histology and spliceopathy in myotonic dystrophy type 1 (DM1) skeletal muscle.

Autor: Ravel-Chapuis A; School of Pharmaceutical Sciences, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; The Eric Poulin Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario, Canada., Fahmi C; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; The Eric Poulin Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario, Canada., Gobin J; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; The Eric Poulin Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario, Canada., Jasmin BJ; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; The Eric Poulin Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario, Canada.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2024 Dec 15; Vol. 38 (23), pp. e70199.

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Akademický článek

Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation

Autor: Alexis Osseni, Aymeric Ravel-Chapuis, Edwige Belotti, Isabella Scionti, Yann-Gaël Gangloff, Vincent Moncollin, Laetitia Mazelin, Remi Mounier, Pascal Leblanc, Bernard J. Jasmin, Laurent Schaeffer

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Here, authors show that Smad3 acetylation via HDAC6 inhibition reverses Duchenne muscular dystrophy-like symptoms in the mdx mouse model, suggesting a potential therapeutic target for the disorder.

Externí odkaz: https://doaj.org/article/cdf9d7e3e2ad4da9b5e4aa9491b771ee

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Akademický článek

Vorinostat Improves Myotonic Dystrophy Type 1 Splicing Abnormalities in DM1 Muscle Cell Lines and Skeletal Muscle from a DM1 Mouse Model.

Autor: Neault, Nafisa^1,2,3 (AUTHOR), Ravel-Chapuis, Aymeric^2,3,4 (AUTHOR), Baird, Stephen D.¹ (AUTHOR), Lunde, John A.^2,3 (AUTHOR), Poirier, Mathieu¹ (AUTHOR), Staykov, Emiliyan¹ (AUTHOR), Plaza-Diaz, Julio^1,5,6 (AUTHOR), Medina, Gerardo¹ (AUTHOR), Abadía-Molina, Francisco^7,8 (AUTHOR), Jasmin, Bernard J.^2,3 (AUTHOR), MacKenzie, Alex E.^1,2,3 (AUTHOR) mackenzie@cheo.on.ca

Publikováno v: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p3794. 24p.

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Akademický článek

Combinatorial therapies for rescuing myotonic dystrophy type 1 skeletal muscle defects

Autor: Ravel-Chapuis, Aymeric, Jasmin, Bernard J.

Publikováno v: In Trends in Molecular Medicine June 2022 28(6):439-442

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Akademický článek

AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency

Autor: Jennifer Karmouch, Perrine Delers, Fannie Semprez, Nouha Soyed, Julie Areias, Guy Bélanger, Aymeric Ravel-Chapuis, Alexandre Dobbertin, Bernard J. Jasmin, Claire Legay

Publikováno v: Frontiers in Molecular Neuroscience, Vol 13 (2020)

Collagen Q (COLQ) is a specific collagen that anchors acetylcholinesterase (AChE) in the synaptic cleft of the neuromuscular junction. So far, no mutation has been identified in the ACHE human gene but over 50 different mutations in the COLQ gene are

Externí odkaz: https://doaj.org/article/d01ca21843fd4ff3a761d1c86a17dfbd

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