Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option.

Autor: Uroz M; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA., Stoddard AE; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA.; Harvard-MIT Program in Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Sutherland BP; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA., Courbot O; Cell and Tissue Mechanobiology Laboratory, The Francis Crick Institute, London, UK.; Department of Physics, King's College London, London, UK., Oria R; Department of Surgery, University of California, San Francisco, CA, USA.; Center for Bioengineering and Tissue Regeneration, University of California San Francisco, San Francisco, CA, USA., Li L; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA.; Department of Chemical Engineering, University of New Hampshire, Durham, NH, USA., Ravasio CR; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Ngo MT; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA., Yang J; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA., Tefft JB; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA., Eyckmans J; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA., Han X; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Elosegui-Artola A; Cell and Tissue Mechanobiology Laboratory, The Francis Crick Institute, London, UK.; Department of Physics, King's College London, London, UK., Weaver VM; Department of Surgery, University of California, San Francisco, CA, USA.; Center for Bioengineering and Tissue Regeneration, University of California San Francisco, San Francisco, CA, USA.; UCSF Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA., Chen CS; Department of Biomedical Engineering, Boston University, Boston, MA, USA. chencs@bu.edu.; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. chencs@bu.edu.; Biological Design Center, Boston University, Boston, MA, USA. chencs@bu.edu.

Publikováno v: Nature cell biology [Nat Cell Biol] 2024 Oct 24. Date of Electronic Publication: 2024 Oct 24.