Fam60A plays a role for production stabilities of recombinant CHO cell lines

Autor: Ritter, A., Nuciforo, S., Schulze, A., Oertli, M., Rauschert, T., Voedisch, B., Geisse, S., Jostock, T., Laux, H.

Recombinant CHO (Chinese hamster ovary) cell lines producing therapeutic proteins often lose their production capability during long-term cultivation. To ensure that CHO production cell lines can be up-scaled to high-volume bioreactors, labor intensi

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https://publica.fraunhofer.de/handle/publica/251804

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Fam60A plays a role for production stabilities of recombinant CHO cell lines.

Autor: Ritter A; Novartis Institutes for BioMedical Research, Basel, Switzerland.; Novartis Pharma AG, Integrated Biologics Profiling Unit, Werk Klybeck Postfach, CH-4002, Basel, Switzerland., Nuciforo S; Novartis Pharma AG, Integrated Biologics Profiling Unit, Werk Klybeck Postfach, CH-4002, Basel, Switzerland., Schulze A; Novartis Pharma AG, Integrated Biologics Profiling Unit, Werk Klybeck Postfach, CH-4002, Basel, Switzerland., Oertli M; Novartis Institutes for BioMedical Research, Basel, Switzerland.; Novartis Pharma AG, Integrated Biologics Profiling Unit, Werk Klybeck Postfach, CH-4002, Basel, Switzerland., Rauschert T; Novartis Pharma AG, Cell and Gene Therapies, Basel, Switzerland., Voedisch B; Novartis Institutes for BioMedical Research, Basel, Switzerland., Geisse S; Novartis Institutes for BioMedical Research, Basel, Switzerland., Jostock T; Novartis Pharma AG, Integrated Biologics Profiling Unit, Werk Klybeck Postfach, CH-4002, Basel, Switzerland., Laux H; Novartis Pharma AG, Integrated Biologics Profiling Unit, Werk Klybeck Postfach, CH-4002, Basel, Switzerland.

Publikováno v: Biotechnology and bioengineering [Biotechnol Bioeng] 2017 Mar; Vol. 114 (3), pp. 701-704. Date of Electronic Publication: 2016 Sep 22.