Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Raulo Parmegiani"'
Autor:
Raymond G. Lovey, Anthony Cacciapuoti, David Loebenberg, Paul Blundell, Viyyoor M. Girijavallabhan, Anil K. Saksena, Henry Guzik, Raulo Parmegiani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1739-1742
The four 2,2,5-regioisomer counterparts of SCH 51048 were synthesized and evaluated. As with the parent series, only the two cis isomers possessed any in vitro activity, and only the activity of the isomer with the R-configuration at the tetrahydrofu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16289fcab93054bcc52426648f5c37a
https://doi.org/10.1016/s0960-894x(02)00282-2
https://doi.org/10.1016/s0960-894x(02)00282-2
Autor:
Anil K. Saksena, David Loebenberg, Raymond G. Lovey, Raulo Parmegiani, Viyyoor M. Girijavallabhan, Jagdish A. Desai, Russell E. Pike, Roberta S. Hare, Ashit K. Ganguly, Anthony Cacciapuoti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2023-2028
Sharpless-Katsuki asymmetric epoxidation of 1 provided the (R)-(+)- and (S)-(−) epoxy alcohols 2R and 2S as key intermediates towards all six stereoisomers of the title compounds. Sch 50001 and Sch 50002 (the “eutomers” of Sch 45012) are novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52580594727393e89566b91b68c873c2
https://doi.org/10.1016/s0960-894x(01)80556-4
https://doi.org/10.1016/s0960-894x(01)80556-4
Autor:
Raymond G. Lovey, Ashit K. Ganguly, Anthony Cacciapuoti, Jagdish A. Desai, Alan B. Cooper, Anil K. Saksena, David Loebenberg, V. Girijavallabhan, Raulo Parmegiani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1079-1084
A convenient degradation of readily available polyoxin D under Edman conditions gave carboxyuracil polyoxin C 3 in high yield. Decarboxylation to uracil polyoxin C 5 (UPOC) and ring contraction to imidazolone compound 8 , gav important nikkomycin Z a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::004b7f4e6b7ae4181e1e5fa36e3b8de9
https://doi.org/10.1016/s0960-894x(00)80291-7
https://doi.org/10.1016/s0960-894x(00)80291-7
Autor:
Raulo Parmegiani, B Antonacci, F. Menzel, George H. Miller, Taisa Yarosh-Tomaine, Anthony Cacciapuoti, Christine Norris, David Loebenberg, L. Moss, Roberta S. Hare
Publikováno v:
Medical Mycology. 31:239-248
Sch 39304 is a new broad spectrum triazole antifungal agent that is active, orally and topically, against superficial Trichophyton mentagrophytes and vaginal Candida albicans infections. Sch 39304 was compared to fluconazole (FLZ) in a T. mentagrophy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624879f1da22add605fc2dce911be378
https://doi.org/10.1080/02681219380000291
https://doi.org/10.1080/02681219380000291
Autor:
Raulo Parmegiani, M. S. Puar, David Loebenberg, D. F. Rane, Anil K. Saksena, V. Girijavallabhan
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::793ba7984338ed645c8a8f506f6eee4a
https://doi.org/10.1002/chin.199446128
https://doi.org/10.1002/chin.199446128
Autor:
Paul Blundell, David Loebenberg, Viyyoor M. Girijavallabhan, Henry Guzik, Raulo Parmegiani, Anil K. Saksena, Anthony Cacciapuoti, Raymond G. Lovey
Publikováno v:
ChemInform. 33
The four 2,2,5-regioisomer counterparts of SCH 51048 were synthesized and evaluated. As with the parent series, only the two cis isomers possessed any in vitro activity, and only the activity of the isomer with the R-configuration at the tetrahydrofu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f58cc24239b4e5fba4be3381905f7ecf
https://doi.org/10.1002/chin.200243190
https://doi.org/10.1002/chin.200243190
Autor:
David Loebenberg, V. Girijavallabhan, Raulo Parmegiani, B Antonacci, D. F. Rane, Arthur J. Elliott, Russell E. Pike, James J. Kaminski, Henry Guzik, Raymond G. Lovey
Publikováno v:
Journal of Medicinal Chemistry. 35:4221-4229
A series of halogen-substituted isobenzofuran analogues was synthesized, which represented conformationally constrained analogues of miconazole (1). In vitro and in vivo topical antifungal activity against both dermatophytes and Candida species varie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8100a2432a74b0d572e73cee1fe0fe
https://doi.org/10.1021/jm00100a030
https://doi.org/10.1021/jm00100a030
Autor:
Christine Norris, David Loebenberg, Raulo Parmegiani, Taisa Yarosh-Tomaine, F. Menzel, Roberta S. Hare, George H. Miller, B Antonacci, Eugene L. Moss, Anthony Cacciapuoti
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:498-501
SCH 39304, a new triazole antifungal agent, is a 50:50 racemic mixture of two enantiomers, SCH 42427 and SCH 42426. The activities of these three compounds were compared in a series of in vitro and in vivo experiments. SCH 42427 was twofold more acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35886255e92d3e409b2bc48101e9bb0a
https://doi.org/10.1128/aac.36.2.498
https://doi.org/10.1128/aac.36.2.498
Autor:
Paul M. McNicholas, Cara Mendrick, Scott S. Walker, Roberta S. Hare, David Loebenberg, Beth DiDomenico, Xin Li, Paul A. Mann, Shui-Qing Wei, Raulo Parmegiani
Publikováno v:
Antimicrobial agents and chemotherapy. 47(2)
The last decade has seen a dramatic increase in serious fungal infections. Those primarily at risk are immunocompromised individuals. Up to 80% of human immunodeficiency virus-infected patients are thought to develop a fungal infection at some point
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f6a7ba77bc4b69b5b85881052fc690
https://pubmed.ncbi.nlm.nih.gov/12543662
https://pubmed.ncbi.nlm.nih.gov/12543662
Autor:
Christine Norris, David Loebenberg, Cara Mendrick, B Antonacci, Taisa Yarosh-Tomaine, Erik Corcoran, Judith Halpern, Brian Arnold, Kimberly Raynor, Roberta S. Hare, George H. Miller, Fred Menzel, Anthony Cacciapuoti, Monika Michalski, Raulo Parmegiani, Eugene L. Moss
Publikováno v:
Antimicrobial agents and chemotherapy. 44(8)
SCH 56592 (posaconazole), a new triazole antifungal agent, was tested in vitro, and its activity was compared to that of itraconazole against 39 Aspergillus strains and to that of fluconazole against 275 Candida and 9 Cryptococcus strains. The SCH 56
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9e739e84c869c1151890dfb885f704
https://pubmed.ncbi.nlm.nih.gov/10898669
https://pubmed.ncbi.nlm.nih.gov/10898669