Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.

Autor: Kloske CM; Alzheimer's Association, Chicago, Illinois, USA., Belloy ME; Department of Neurology and Neurological Sciences, Stanford University, Stanford, Palo Alto, California, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, St. Louis, Missouri, USA., Blue EE; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington, USA.; Institute for Public Health Genetics, University of Washington, Seattle, Washington, USA., Bowman GR; Departments of Biochemistry & Biophysics and Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Carrillo MC; Alzheimer's Association, Chicago, Illinois, USA., Chen X; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA., Chiba-Falek O; Division of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA., Davis AA; Department of Neurology Hope Center for Neurological Disorders Washington University School of Medicine, St. Louis, Missouri, USA., Paolo GD; Denali Therapeutics Inc., San Francisco, California, USA., Garretti F; Ronald M. Loeb Center for Alzheimer's Disease, New York, New York, USA.; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Gate D; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Golden LR; Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA., Heinecke JW; Department of Medicine, University of Washington, UV Medicine, Seattle, Washington, USA., Herz J; Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Huang Y; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, USA.; Department of Neurology, University of California, San Francisco, California, USA., Iadecola C; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA., Johnson LA; Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA., Kanekiyo T; Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA., Karch CM; Department of Psychiatry, Washington University in St Louis, St. Louis, Missouri, USA., Khvorova A; RNA Therapeutic Institute, UMass Chan Medical School, Worcester, Massachusetts, USA., Koppes-den Hertog SJ; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, USA.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, USA., Lamb BT; Stark Neurosciences Research Institute Indiana University School of Medicine, Indianapolis, Indiana, USA., Lawler PE; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, St. Louis, Missouri, USA.; The Tracy Family SILQ Center, Washington University School of Medicine, Indianapolis, Indiana, USA., Guen YL; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.; Institut du Cerveau-Paris Brain Institute-ICM, Paris, France., Litvinchuk A; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA., Liu CC; Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA., Mahinrad S; Alzheimer's Association, Chicago, Illinois, USA., Marcora E; Department of Genetics and Genomic Sciences, Nash Family Department of Neuroscience, Icahn Genomics Institute; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Marino C; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Michaelson DM; Sagol School of Neuroscience Tel Aviv University, Tel Aviv, Israel., Miller JJ; Departments of Biochemistry & Biophysics and Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA., Morganti JM; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA., Narayan PS; Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, Center for Alzheimer's and Related Dementias (CARD), National Institutes of Health, Maryland, USA., Naslavsky MS; Human Genome and Stem-cell Research Center, Biosciences Institute, University of São Paulo, Rua do Matao, São Paulo, Brazil.; Hospital Israelita Albert Einstein, Avenida Albert Einstein, São Paulo, Brazil., Oosthoek M; Neurochemistry Laboratory, Department of Laboratory Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands., Ramachandran KV; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.; Department of Neuroscience, Columbia University Vagelos College of Physicians and Surgeons, New York, USA., Ramakrishnan A; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Raulin AC; Mayo Clinic Florida, Jacksonville, Florida, USA., Robert A; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, USA.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, USA., Saleh RNM; Norwich Medical School, University of East Anglia, UK Clinical and Chemical Pathology, Norfolk, UK.; Faculty of Medicine, Alexandria University, Alexandria Governorate, Egypt., Sexton C; Alzheimer's Association, Chicago, Illinois, USA., Shah N; Lexeo Therapeutics, New York, New York, USA., Shue F; Mayo Clinic Florida, Jacksonville, Florida, USA., Sible IJ; University of Southern California, Los Angeles, California, USA., Soranno A; Washington University in Saint Louis, St. Louis, Missouri, USA, St. Louis, Missouri, USA., Strickland MR; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, St. Louis, Missouri, USA., Tcw J; Department of Pharmacology, Physiology & Biophysics, Chobanian and Avedisian School of Medicine, Boston University, Boston, Massachusetts, USA.; Bioinformatics Program, Faculty of Computing & Data Sciences, Boston University, Boston, Massachusetts, USA., Thierry M; Center for Cognitive Neurology, Department of Neurology, New York University Grossman School of Medicine, New York, New York, USA., Tsai LH; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Tuckey RA; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, Alabama, USA., Ulrich JD; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA., van der Kant R; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, USA.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, USA., Wang N; Mayo Clinic Rochester, Rochester, Minnesota, USA., Wellington CL; Djavad Mowafaghian Centre for Brain Health Department of Pathology and Laboratory Medicine International Collaboration on Repair Discoveries School of Biomedical Engineering University of British Columbia, Vancouver, Canada., Weninger SC; FBRI, Massachusetts, USA., Yassine HN; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Zhao N; Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA., Bu G; Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong., Goate AM; Department of Genetics & Genomic Sciences, Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Sep; Vol. 20 (9), pp. 6590-6605. Date of Electronic Publication: 2024 Jul 19.

Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease.

Autor: Liu CC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. liu.chiachenjen@gmail.com.; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA, USA. liu.chiachenjen@gmail.com., Wang N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Chen Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Inoue Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Shue F; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Ren Y; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA., Wang M; Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Qiao W; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Ikezu TC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Li Z; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Zhao J; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Martens Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Doss SV; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Rosenberg CL; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Jeevaratnam S; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Jia L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Raulin AC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Qi F; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Zhu Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Alnobani A; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Knight J; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Chen Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Linares C; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Kurti A; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Fryer JD; Department of Neuroscience, Mayo Clinic, Scottsdale, AZ, USA., Zhang B; Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wu LJ; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Kim BYS; Department of Neurosurgery, The Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bu G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. gbu@ust.hk.; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China. gbu@ust.hk.

Publikováno v: Nature immunology [Nat Immunol] 2023 Nov; Vol. 24 (11), pp. 1854-1866. Date of Electronic Publication: 2023 Oct 19.

An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells.

Autor: Raulin AC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address: raulin.ana-caroline@mayo.edu., Liu CC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address: liu.chiachen@mayo.edu., Bu G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address: guojun.bu@molecularneurodegeneration.org.

Publikováno v: STAR protocols [STAR Protoc] 2023 Mar 17; Vol. 4 (1), pp. 101976. Date of Electronic Publication: 2023 Jan 03.

A reference human induced pluripotent stem cell line for large-scale collaborative studies.

Autor: Pantazis CB; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Yang A; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK; Wellcome Trust - Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK., Lara E; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., McDonough JA; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Blauwendraat C; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Peng L; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International LLC, Washington, DC, USA; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA., Oguro H; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA; Department of Cell Biology, University of Connecticut Health Center, Farmington, CT, USA., Kanaujiya J; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA; Department of Cell Biology, University of Connecticut Health Center, Farmington, CT, USA., Zou J; iPS Cell Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Sebesta D; KromaTiD Inc., Longmont, CO, USA., Pratt G; KromaTiD Inc., Longmont, CO, USA., Cross E; KromaTiD Inc., Longmont, CO, USA., Blockwick J; KromaTiD Inc., Longmont, CO, USA., Buxton P; KromaTiD Inc., Longmont, CO, USA., Kinner-Bibeau L; KromaTiD Inc., Longmont, CO, USA., Medura C; KromaTiD Inc., Longmont, CO, USA., Tompkins C; KromaTiD Inc., Longmont, CO, USA., Hughes S; KromaTiD Inc., Longmont, CO, USA., Santiana M; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Faghri F; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International LLC, Washington, DC, USA., Nalls MA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International LLC, Washington, DC, USA., Vitale D; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International LLC, Washington, DC, USA., Ballard S; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International LLC, Washington, DC, USA., Qi YA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Ramos DM; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Anderson KM; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Stadler J; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Narayan P; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Genetics and Biochemistry Branch, NIDDK, NINDS, National Institutes of Health, Bethesda, MD 20814, USA., Papademetriou J; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Reilly L; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Nelson MP; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Aggarwal S; Wellcome Trust - Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK., Rosen LU; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Kirwan P; Wellcome Trust - Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK., Pisupati V; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK., Coon SL; Molecular Genomics Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA., Scholz SW; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA., Priebe T; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam de Boelelaan 1087, 1081 HV Amsterdam, the Netherlands., Öttl M; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam de Boelelaan 1087, 1081 HV Amsterdam, the Netherlands., Dong J; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam de Boelelaan 1087, 1081 HV Amsterdam, the Netherlands., Meijer M; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam de Boelelaan 1087, 1081 HV Amsterdam, the Netherlands., Janssen LJM; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam de Boelelaan 1087, 1081 HV Amsterdam, the Netherlands., Lourenco VS; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam de Boelelaan 1087, 1081 HV Amsterdam, the Netherlands., van der Kant R; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam de Boelelaan 1087, 1081 HV Amsterdam, the Netherlands; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the Netherlands., Crusius D; Institute for Stroke and Dementia Research, University Hospital, LMU Munich, 81377 Munich, Germany., Paquet D; Institute for Stroke and Dementia Research, University Hospital, LMU Munich, 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany., Raulin AC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Bu G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Held A; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Wainger BJ; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA; Broad Institute of Harvard University and MIT, Cambridge, MA, USA., Gabriele RMC; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Casey JM; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Wray S; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Abu-Bonsrah D; The Florey Institute of Neuroscience & Mental Health, The University of Melbourne, Parkville, VIC 3052, Australia; Department of Pediatrics, University of Melbourne, Parkville, VIC 3052, Australia., Parish CL; The Florey Institute of Neuroscience & Mental Health, The University of Melbourne, Parkville, VIC 3052, Australia., Beccari MS; Department of Cellular and Molecular Medicine and Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA., Cleveland DW; Department of Cellular and Molecular Medicine and Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA., Li E; Institute for Neurodegenerative Diseases and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA., Rose IVL; Institute for Neurodegenerative Diseases and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA., Kampmann M; Institute for Neurodegenerative Diseases and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA., Calatayud Aristoy C; VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium., Verstreken P; VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium., Heinrich L; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Chen MY; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Schüle B; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Dou D; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Holzbaur ELF; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zanellati MC; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Basundra R; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Deshmukh M; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Cohen S; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Khanna R; Department of Developmental Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA., Raman M; Department of Developmental Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA., Nevin ZS; Gladstone Institutes, San Francisco, CA, USA., Matia M; Gladstone Institutes, San Francisco, CA, USA., Van Lent J; Peripheral Neuropathy Research Group, Department of Biomedical Sciences, University of Antwerp, Antwerp 2610, Belgium., Timmerman V; Peripheral Neuropathy Research Group, Department of Biomedical Sciences, University of Antwerp, Antwerp 2610, Belgium., Conklin BR; Gladstone Institutes, San Francisco, CA, USA., Johnson Chase K; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Zhang K; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Funes S; Department of Neurology, UMass Chan Medical School, Worcester, MA, USA., Bosco DA; Department of Neurology, UMass Chan Medical School, Worcester, MA, USA., Erlebach L; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Welzer M; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Kronenberg-Versteeg D; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Lyu G; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Arenas E; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Coccia E; Nash Family Department of Neuroscience; Departments of Neurology and Cell, Developmental and Regenerative Biology; Ronald M. Loeb Center for Alzheimer's Disease; Friedman Brain Institute; Black Family Stem Cell Institute at Mount Sinai, New York, NY, USA., Sarrafha L; Nash Family Department of Neuroscience; Departments of Neurology and Cell, Developmental and Regenerative Biology; Ronald M. Loeb Center for Alzheimer's Disease; Friedman Brain Institute; Black Family Stem Cell Institute at Mount Sinai, New York, NY, USA., Ahfeldt T; Nash Family Department of Neuroscience; Departments of Neurology and Cell, Developmental and Regenerative Biology; Ronald M. Loeb Center for Alzheimer's Disease; Friedman Brain Institute; Black Family Stem Cell Institute at Mount Sinai, New York, NY, USA., Marioni JC; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Skarnes WC; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. Electronic address: bill.skarnes@jax.org., Cookson MR; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. Electronic address: cookson@mail.nih.gov., Ward ME; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Electronic address: michael.ward4@nih.gov., Merkle FT; Wellcome Trust - Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK. Electronic address: fm436@medschl.cam.ac.uk.

Publikováno v: Cell stem cell [Cell Stem Cell] 2022 Dec 01; Vol. 29 (12), pp. 1685-1702.e22.

LRP1 is a neuronal receptor for α-synuclein uptake and spread.

Autor: Chen K; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Martens YA; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Meneses A; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Ryu DH; Departments of Neuroscience and Neurology, University of Florida, Gainesville, FL, 32611, USA., Lu W; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Raulin AC; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Li F; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Zhao J; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Chen Y; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Jin Y; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Linares C; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Goodwin M; Departments of Neuroscience and Neurology, University of Florida, Gainesville, FL, 32611, USA., Li Y; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Liu CC; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Kanekiyo T; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA., Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA., Golde TE; Departments of Neuroscience and Neurology, University of Florida, Gainesville, FL, 32611, USA., Bu G; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA. Guojun.Bu@MolecularNeurodegeneration.Org., Zhao N; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA. zhao.na@mayo.edu.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2022 Sep 02; Vol. 17 (1), pp. 57. Date of Electronic Publication: 2022 Sep 02.