Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1

Autor: Nicolas Vabret, Valérie Najburg, Alexander Solovyov, Ramya Gopal, Christopher McClain, Petr Šulc, Sreekumar Balan, Yannis Rahou, Guillaume Beauclair, Maxime Chazal, Hugo Varet, Rachel Legendre, Odile Sismeiro, Raul Y. Sanchez David, Lise Chauveau, Nolwenn Jouvenet, Martin Markowitz, Sylvie van der Werf, Olivier Schwartz, Frédéric Tangy, Nina Bhardwaj, Benjamin D. Greenbaum, Anastassia V. Komarova

Publikováno v: iScience, Vol 25, Iss 7, Pp 104599- (2022)

Summary: Pattern recognition receptors (PRRs) protect against microbial invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. Although microbial-derived PRR ligands have been extensively characterized

Externí odkaz: https://doaj.org/article/3f866d774d69450aaefc5a05b8e28df1

Comparative analysis of viral RNA signatures on different RIG-I-like receptors

Autor: Raul Y Sanchez David, Chantal Combredet, Odile Sismeiro, Marie-Agnès Dillies, Bernd Jagla, Jean-Yves Coppée, Marie Mura, Mathilde Guerbois Galla, Philippe Despres, Frédéric Tangy, Anastassia V Komarova

Publikováno v: eLife, Vol 5 (2016)

The RIG-I-like receptors (RLRs) play a major role in sensing RNA virus infection to initiate and modulate antiviral immunity. They interact with particular viral RNAs, most of them being still unknown. To decipher the viral RNA signature on RLRs duri

Externí odkaz: https://doaj.org/article/3898575afa66487393e909428ea9971f

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

Autor: Laury Baillon, Rebecca Frise, Jack A. Hassard, Thomas P. Peacock, Mauro Giacca, Brian Hanley, Wendy S. Barclay, Jonathan Brown, Olivia C. Swann, Raul Y. Sanchez-David, David A. Matthews, Rebecca Penn, Luca Braga, Michael Osborn, Ruthiran Kugathasan, Ecco Staller, Andrew D. Davidson, Maia Kavanagh Williamson, Jie Zhou, Daniel H. Goldhill

Publikováno v: Peacock, T P, Kavanagh Williamson, M, Davidson, A D, Matthews, D A, Barclay, W S & al., E 2021, ' The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets ', Nature Microbiology, vol. 6, no. 7, pp. 899-909 . https://doi.org/10.1038/s41564-021-00908-w

SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and the S2' cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion (PRRAR) at the S1/S2 cleavage site that can be cleaved by furin. Using le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e0ee5684faaff04732d4036d11db63
http://hdl.handle.net/10044/1/98544

The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells

Autor: Thomas P. Peacock, Daniel H. Goldhill, Jie Zhou, Laury Baillon, Rebecca Frise, Olivia C. Swann, Ruthiran Kugathasan, Rebecca Penn, Jonathan C. Brown, Raul Y. Sanchez-David, Luca Braga, Maia Kavanagh Williamson, Jack A. Hassard, Ecco Staller, Brian Hanley, Michael Osborn, Mauro Giacca, Andrew D. Davidson, David A. Matthews, Wendy S. Barclay

SummarySARS-CoV-2 enters cells via its spike glycoprotein which must be cleaved sequentially at the S1/S2, then the S2’ cleavage sites (CS) to mediate membrane fusion. SARS-CoV-2 has a unique polybasic insertion at the S1/S2 CS, which we demonstrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0542bb7e250a4a304c64bbea0ebe18cb
https://doi.org/10.1101/2020.09.30.318311

LGP2 binds to PACT to regulate RIG-I– and MDA5-mediated antiviral responses

Autor: Benno Schwikowski, Jacques Bellalou, Valérie Najburg, Jean-Michel Camadro, Guillaume Beauclair, Chantal Combredet, Gaël A. Millot, Yves Jacob, Raul Y. Sanchez David, Anastassia V. Komarova, Thibaut Léger, Frédéric Tangy, Nolwenn Jouvenet

Publikováno v: Science Signaling
Science Signaling, 2019, 12 (601), pp.eaar3993. ⟨10.1126/scisignal.aar3993⟩
Science Signaling, American Association for the Advancement of Science, 2019, 12 (601), pp.eaar3993. ⟨10.1126/scisignal.aar3993⟩

International audience; The retinoic acid–inducible gene I (RIG-I)–like receptors (RLRs) RIG-I, MDA5, and LGP2 stimulate inflammatory and antiviral responses by sensing nonself RNA molecules produced during viral replication. Here, we investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8703fcc7f891632f8fd1afb657a195a9
https://cnrs.hal.science/hal-03100138/document