Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Raul Torres-Ruiz"'
Autor:
Álvaro Gómez-Morón, Sergio Alegre-Gómez, Rocio Ramirez-Muñoz, Alicia Hernaiz-Esteban, Carlos Carrasco-Padilla, Camila Scagnetti, Óscar Aguilar-Sopeña, Marta García-Gil, Aldo Borroto, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Francisco Sánchez-Madrid, Noa Beatriz Martín-Cófreces, Pedro Roda-Navarro
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Actin dynamics control early T-cell receptor (TCR) signalling during T-cell activation. However, the precise regulation of initial actin rearrangements is not completely understood. Here, we have investigated the regulatory role of the phosp
Externí odkaz:
https://doaj.org/article/33e816e2fa6646da9973b85120678fac
Autor:
Paolo Petazzi, Raul Torres-Ruiz, Antonella Fidanza, Heleia Roca-Ho, Francisco Gutierrez-Agüera, Julio Castaño, Sandra Rodriguez-Perales, Rafael Díaz de la Guardia, Belén López-Millán, Anna Bigas, Lesley M. Forrester, Clara Bueno, Pablo Menéndez
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 20, Iss , Pp 196-204 (2020)
Human pluripotent stem cells (hPSCs) and mesenchymal stromal/stem cells (hMSCs) are clinically relevant sources for cellular therapies and for modeling human development and disease. Many stem cell-based applications rely on the ability to activate s
Externí odkaz:
https://doaj.org/article/f77cc3d8fc8949cb8341a5d7065e2798
Autor:
Raul Torres-Ruiz, Tatiana P. Grazioso, Marta Brandt, Marta Martinez-Lage, Sandra Rodriguez-Perales, Nabil Djouder
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100631- (2021)
Summary: Chromosomal instability (CIN), a type of genomic instability, favors changes in chromosome number and structure and it is associated with the progression and initiation of multiple diseases, including cancer. Therefore, CIN identification an
Externí odkaz:
https://doaj.org/article/6fbe6d7e6948469cb8130152a1b8f88e
Autor:
Barbara Oldrini, Álvaro Curiel-García, Carolina Marques, Veronica Matia, Özge Uluçkan, Osvaldo Graña-Castro, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Jason T. Huse, Massimo Squatrito
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Accurate recapitulation of human disease in animal models requires generation of complex and heterogeneous genetic variation. Here the authors combine RCAS-TVA with CRISPR-Cas9 to generate mouse models of cancer.
Externí odkaz:
https://doaj.org/article/fd236016877346748003cdfce0070291
Autor:
Raul Torres-Ruiz, Marta Martinez-Lage, Maria C. Martin, Aida Garcia, Clara Bueno, Julio Castaño, Juan C. Ramirez, Pablo Menendez, Juan C. Cigudosa, Sandra Rodriguez-Perales
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1408-1420 (2017)
Efficient methodologies for recreating cancer-associated chromosome translocations are in high demand as tools for investigating how such events initiate cancer. The CRISPR/Cas9 system has been used to reconstruct the genetics of these complex rearra
Externí odkaz:
https://doaj.org/article/780919482ffd49d4a410c727e962bb2a
Autor:
Clara Bueno, Fernando J Calero-Nieto, Xiaonan Wang, Rafael Valdés-Mas, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Veronica Ayllon, Pedro J Real, David Arambilet, Lluis Espinosa, Raul Torres-Ruiz, Antonio Agraz-Doblas, Ignacio Varela, Jasper de Boer, Anna Bigas, Bertie Gottgens, Rolf Marschalek, Pablo Menendez
Publikováno v:
Haematologica, Vol 104, Iss 6 (2019)
The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis. The developmental/pathogenic contribution of the t(4;11)-resulting MLL-AF4 (MA4
Externí odkaz:
https://doaj.org/article/c6cca9f1e10144babdafb62ac067bf29
Autor:
Alvaro Torres-Gomez, Jose Luis Sanchez-Trincado, Víctor Toribio, Raul Torres-Ruiz, Sandra Rodríguez-Perales, María Yáñez-Mó, Pedro A. Reche, Carlos Cabañas, Esther M. Lafuente
Publikováno v:
Cells, Vol 9, Iss 5, p 1166 (2020)
The phagocytic integrins and complement receptors αMβ2/CR3 and αXβ2/CR4 are classically associated with the phagocytosis of iC3b-opsonized particles. The activation of this receptor is dependent on signals derived from other receptors (inside-out
Externí odkaz:
https://doaj.org/article/047e95a30f824c5b924141d775342864
Autor:
Marta Martinez-Lage, Pilar Puig-Serra, Pablo Menendez, Raul Torres-Ruiz, Sandra Rodriguez-Perales
Publikováno v:
Biomedicines, Vol 6, Iss 4, p 105 (2018)
Cancer is the second leading cause of death globally and remains a major economic and social burden. Although our understanding of cancer at the molecular level continues to improve, more effort is needed to develop new therapeutic tools and approach
Externí odkaz:
https://doaj.org/article/1072d8d705d44a0493545632fce87bd7
Autor:
Lahera, Antonio, Vela-Martín, Laura, López-Nieva, Pilar, Salgado, Rocío N, Rodriguez Perales, Sandra, Raul, Torres-Ruiz, López-Lorenzo, José L, Cornago, Javier, Llamas, Pilar, Fernandez-Navarro, Pablo L, Sánchez-Domínguez, Rebeca, Segovia, José C, Sastre, Isabel, Cobos-Fernández, María Á, Menéndez, Pablo, Santos, Javier, Fernández-Piqueras, José, Villa-Morales, María
Sí
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4734::279bb2f99a36ca410c5af63fac31e716
https://hdl.handle.net/20.500.12105/16169
https://hdl.handle.net/20.500.12105/16169
Autor:
Ken H. Young, Gordon J. Freeman, Yong Li, George Z. Rassidakis, L. Jeffrey Medeiros, Lan V. Pham, Jason R. Westin, Jane N. Winter, J. Han van Krieken, Miguel A. Piris, Michael B. Møller, Andrés J.M. Ferreri, Maurilio Ponzoni, Eric D. Hsi, Govind Bhagat, Hua You, Wayne Tam, Karen Dybkær, Jing Wang, Alexandar Tzankov, Hongwei Zhang, Xiaohong Tan, Yi Miao, Carlo Visco, Ganiraju C. Manyam, Raul Torres-Ruiz, Sandra Rodríguez-Perales, Nicholas Hoe, Bing Xu, Raghav Padmanabhan, Qingyan Au, Min Xiao, Ziju Y. Xu-Monette
PD-1/L1 and CTLA-4 blockade immunotherapies have been approved for 13 types of cancers and are being studied in diffuse large B-cell lymphoma (DLBCL), the most common aggressive B-cell lymphoma. However, whether both PD-1 and CTLA-4 checkpoints are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2004bbfc600786a4399e7da7d1869196
https://doi.org/10.1158/2326-6066.c.6548953.v1
https://doi.org/10.1158/2326-6066.c.6548953.v1