Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Raul Sanoja"'
Autor:
Rebecca M. Klein, Mark E. Layton, Hillary Regan, Christopher P. Regan, Yuxing Li, Tracey Filzen, Matt Cato, Michelle K. Clements, Jixin Wang, Raul Sanoja, Thomas J. Greshock, Anthony J. Roecker, Joseph E. Pero, Ron Kim, Christopher Burgey, Christopher T. John, Ying-Hong Wang, Neetesh Bhandari, Arie Struyk, Richard L. Kraus, Darrell A. Henze, Andrea K. Houghton
Publikováno v:
Channels, Vol 16, Iss 1, Pp 230-243 (2022)
As part of a drug discovery effort to identify potent inhibitors of NaV1.7 for the treatment of pain, we observed that inhibitors produced unexpected cardiovascular and respiratory effects in vivo. Specifically, inhibitors administered to rodents pro
Externí odkaz:
https://doaj.org/article/55057518620746559c951066d12dfcf1
Autor:
Ditte Lovatt, Alex Tamburino, Alicja Krasowska-Zoladek, Raul Sanoja, Lixia Li, Vanessa Peterson, Xiaohai Wang, Jason Uslaner
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Single-cell RNA-seq analysis of naive and injured sensory nerves in a rat model provide further insight into the molecular pathways underlying nerve injury, regeneration, and repair.
Externí odkaz:
https://doaj.org/article/2edeb25a77a54bae9f35252186d3da78
Autor:
Steven M, Grauer, Raul, Sanoja, Dominic, Poulin, Harunor, Rashid, Nina, Jochnowitz, Michael, Calhoun, Daniel, Zwilling, Geoffrey B, Varty, Thomas W, Rosahl, Hamid, Meziane, Christopher, Mittlelhaeuser, Robert, Mazzola, John, Morrow, Sean M, Smith, Darrell, Henze, Jacob, Marcus
Publikováno v:
Brain research. 1737
Analgesic properties of orthosteric agonists of the muscarinic M
Autor:
Terrence P. McDonald, Christopher J. Winrow, Anthony L. Gotter, Hongyu A Liang, Paul J. Coleman, Karen M. Smith, John J. Renger, Scott D. Kuduk, Raul Sanoja
Publikováno v:
Journal of Neurogenetics. 30:32-41
Orexin signaling, known to modulate arousal and vigilance, is also involved in nociception as orexin neurons project to regions of the brain and spinal cord involved in pain processing, and the administration of orexin peptides can alter pain respons
Autor:
John A. Morrow, Raul Sanoja, Jacob Marcus, Daniel Zwilling, Darrell A. Henze, Nina Jochnowitz, Christopher Mittlelhaeuser, Robert Mazzola, Michael Calhoun, Hamid Meziane, Harunor Rashid, Dominic Poulin, Sean M. Smith, Thomas W. Rosahl, Geoffrey B. Varty, Steven M. Grauer
Publikováno v:
Brain Research. 1737:146814
Analgesic properties of orthosteric agonists of the muscarinic M4 receptor subtype have been documented in literature reports, with evidence from pharmacological and in vivo receptor knock out (KO) studies. Constitutive M4 receptor KO mice demonstrat
Publikováno v:
The Journal of Neuroscience. 33:15109-15119
Spinal nociceptive neurons are well known to undergo a process of long-term potentiation (LTP) following conditioning by high-frequency sciatic nerve stimulation (HFS) at intensities recruiting C-fibers. However, little if any information exists as t
Autor:
Adia Shy, Frank Porreca, Theodore J. Price, Marina N. Asiedu, Ohannes K. Melemedjian, Dipti V. Tillu, Raul Sanoja, Bryce Bodell, Sourav Ghosh
Publikováno v:
The Journal of Neuroscience. 31:6646-6653
Sensitization of the pain pathway is believed to promote clinical pain disorders. We hypothesized that the persistence of a sensitized state in the spinal dorsal horn might depend on the activity of protein kinase M ζ (PKMζ), an essential mechanism
Autor:
Raul Sanoja, Fernando Cervero
Publikováno v:
Autonomic Neuroscience. 153:84-89
Many forms of chronic pain are more prevalent in women and this is interpreted as the consequence of a direct role of estrogens in the modulation of pain perception. Some functional pain states, i.e. those without a clear and demonstrable pathology,
Publikováno v:
The Journal of Pain. 9:532-542
Neuropathic pain is a major clinical problem, and several animal models have been developed to investigate its mechanisms and its treatment. In this report, the role of the rostral ventromedial medulla (RVM) in the early events of the chronic constri
Autor:
Magali Millecamps, Raul Sanoja, Harunor Rashid, Fernando Cervero, Theodore J. Price, José Manuel Entrena
Publikováno v:
The Journal of Neuroscience. 27:13958-13967
Fragile X mental retardation is caused by silencing of the gene (FMR1) that encodes the RNA-binding protein (FMRP) that influences translation in neurons. A prominent feature of the human disorder is self-injurious behavior, suggesting an abnormality