Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Raul Covian"'
Autor:
Raul Covian, Lanelle Edwards, Yi He, Geumsoo Kim, Carly Houghton, Rodney L. Levine, Robert S. Balaban
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Paracoccus denitrificans is a model organism for the study of oxidative phosphorylation. We demonstrate a very high respiratory capacity compared to mitochondria when normalizing to cytochrome aa3 content even in the absence of alternative terminal o
Externí odkaz:
https://doaj.org/article/a5e7aed6cf7241dbb9c720022bbb9dbc
Autor:
Ximena Corso-Díaz, James Gentry, Ryan Rebernick, Catherine Jaeger, Matthew J. Brooks, Freekje van Asten, Keshav Kooragayala, Linn Gieser, Jacob Nellissery, Raul Covian, Tiziana Cogliati, Anupam K. Mondal, Ke Jiang, Anand Swaroop
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Aging-associated functional decline is accompanied by alterations in the epigenome. To explore DNA modifications that could influence visual function with age, we perform whole-genome bisulfite sequencing of purified mouse rod photoreceptors
Externí odkaz:
https://doaj.org/article/25ae7742317d45db9846aac289aa4b49
Autor:
Yingfan Zhang, T. Bradley Willingham, Laura Reyes, Chengyu Liu, Danielle Springer, Audrey Noguchi, Angel M. Aponte, Jeeva Munasinghe, Raul Covian, Brian Glancy
Depletion of transmembrane protein 65 (TMEM65) in a patient with a homozygous point mutation in the TMEM65 gene splice site was reported to result in mitochondrial dysfunction and severe encephalomyopathy(1), indicating the clinical importance of TME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d00932474052bdc5591e0a48e335f116
https://doi.org/10.1101/2022.08.02.502535
https://doi.org/10.1101/2022.08.02.502535
Publikováno v:
Biochimica et biophysica acta. Bioenergetics. 1864(2)
The catalytic cycle of cytochrome c oxidase (COX) couples the reduction of oxygen to the translocation of protons across the inner mitochondrial membrane and involves several intermediate states of the heme a
Autor:
Ke Jiang, Anupam Kumar Mondal, Yogita K Adlakha, Jessica Gumerson, Angel Aponte, Linn Gieser, Jung-Woong Kim, Alexis Boleda, Matthew J Brooks, Jacob Nellissery, Donald A Fox, Robert Balaban, Raul Covian, Anand Swaroop
Publikováno v:
Hum Mol Genet
Retinal diseases exhibit extensive genetic heterogeneity and complex etiology with varying onset and severity. Mutations in over 200 genes can lead to photoreceptor dysfunction and/or cell death in retinal neurodegeneration. To deduce molecular pathw
Autor:
Matthew Brooks, Jessica D. Gumerson, Alexis Boleda, Anupam Kumar Mondal, Raul Covian, Linn Gieser, Anand Swaroop, Ke Jiang, Donald A. Fox, Robert S. Balaban, Yogita K. Adlakha, Jacob Nellissery, Jung-Woong Kim, Angel Aponte
Neurodegenerative diseases exhibit extensive genetic heterogeneity and complex etiology with varying onset and severity. To deduce the mechanism leading to retinal degeneration, we adopted a temporal multi-omics approach and examined molecular and ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74ab179419b48f7ec7f49d6bbf4b3c57
https://doi.org/10.1101/2021.10.10.463827
https://doi.org/10.1101/2021.10.10.463827
Autor:
Abigail V. Giles, Armel N. Femnou, Elizabeth Murphy, Raul Covian, Robert S. Balaban, Junhui Sun, Joni Taylor, Sarah Kuzmiak-Glancy
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 315:H1791-H1804
The isolated saline-perfused heart is used extensively to study cardiac physiology. Previous isolated heart studies have demonstrated lower tissue oxygenation compared with in vivo hearts based on myoglobin oxygenation and the mitochondrial redox sta
Autor:
Raul Covian, Linn Gieser, Anand Swaroop, James Gentry, Ximena Corso-Díaz, Freekje van Asten, Jacob Nellissery, Ryan Rebernick, Ke Jiang, Catherine Jaeger, Anupam Kumar Mondal, Keshav Kooragayala, Tiziana Cogliati, Matthew Brooks
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp-(2020)
Cell Reports, 31, 3
Cell Reports, 31
Cell Rep
Cell Reports, 31, 3
Cell Reports, 31
Cell Rep
Summary: Aging-associated functional decline is accompanied by alterations in the epigenome. To explore DNA modifications that could influence visual function with age, we perform whole-genome bisulfite sequencing of purified mouse rod photoreceptors
Autor:
Anastasia M. Wengrowski, Matthew W. Kay, Rafael Jaimes, Robert S. Balaban, Sarah Kuzmiak-Glancy, Kara Garrott, Raul Covian, Brian Glancy, Armel N. Femnou, Stephanie French
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 314:H704-H715
The left ventricular working, crystalloid-perfused heart is used extensively to evaluate basic cardiac function, pathophysiology, and pharmacology. Crystalloid-perfused hearts may be limited by oxygen delivery, as adding oxygen carriers increases myo
Autor:
Robert S. Balaban, Armel N. Femnou, Raul Covian, Matthew W. Kay, Sarah Kuzmiak-Glancy, Abigail V. Giles
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 313:H1199-H1208
Absorbance spectroscopy of intrinsic cardiac chromophores provides nondestructive assessment of cytosolic oxygenation and mitochondria redox state. Isolated perfused heart spectroscopy is usually conducted by collecting reflected light from the heart