Zobrazeno 1 - 10
of 650
pro vyhledávání: '"Raul C. Ribeiro"'
Autor:
Abdelrahman H. Elsayed, Xueyuan Cao, Richard J. Marrero, Nam H. K. Nguyen, Huiyun Wu, Yonhui Ni, Raul C. Ribeiro, Herold Tobias, Peter J. Valk, François Béliveau, Guillaume Richard-Carpentier, Josée Hébert, C. Michel Zwaan, Alan Gamis, Edward Anders Kolb, Richard Aplenc, Todd A. Alonzo, Soheil Meshinchi, Jeffrey Rubnitz, Stanley Pounds, Jatinder K. Lamba
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract In this study, we leveraged machine-learning tools by evaluating expression of genes of pharmacological relevance to standard-AML chemotherapy (ara-C/daunorubicin/etoposide) in a discovery-cohort of pediatric AML patients (N = 163; NCT001360
Externí odkaz:
https://doaj.org/article/8d2e5546c18f4cf3998b81a1211405a0
Autor:
Maria Riedmeier, Sonir Antonini, Clemens Benoit, Cheri L. Deal, Fassnacht Martin, Bonald C. Figueiredo, Elmas Nazli Gonc, Christoph Härtel, Jan Idkowiak, Max Kurlbaum, Ronald de Krijger, Raul C. Ribeiro, Jaydira del Rivero, Paul-Gerhardt Schlegel, Lester D.R. Thompson, Bilgehan Yalcin, Verena Wiegering
Publikováno v:
Pediatric Hematology Oncology Journal, Vol 9, Iss 2, Pp 74-77 (2024)
Background: Mitotane is employed as adjuvant therapy in managing adrenocortical carcinoma in pediatric patients. While various adverse effects, such as estrogen-like manifestations, are well-documented in adults, there is limited knowledge regarding
Externí odkaz:
https://doaj.org/article/c5c6a99c16b6466dae3500b25dbf08f2
Autor:
Emilia M. Pinto, Cintia Fridman, Bonald C. Figueiredo, Hector Salvador, Manuel R. Teixeira, Carla Pinto, Manuela Pinheiro, Christian P. Kratz, Cinzia Lavarino, Edith A.M. F. Legal, Anh Le, Gregory Kelly, Erika Koeppe, Elena M. Stoffel, Kelsey Breen, Stefanie Hahner, Britta Heinze, Piti Techavichit, Amanda Krause, Tsutomu Ogata, Yasuko Fujisawa, Michael F. Walsh, Huma Q. Rana, Kara N. Maxwell, Judy E. Garber, Carlos Rodriguez-Galindo, Raul C. Ribeiro, Gerard P. Zambetti
Publikováno v:
HGG Advances, Vol 5, Iss 1, Pp 100244- (2024)
Summary: The germline TP53 p.R337H mutation is reported as the most common germline TP53 variant. It exists at a remarkably high frequency in the population of southeast Brazil as founder mutation in two distinct haplotypes with the most frequent co-
Externí odkaz:
https://doaj.org/article/02c8af13bfa145bdbadf55670897ec29
Autor:
Perla R. Colunga-Pedraza, Julia E. Colunga-Pedraza, Samantha P. Peña-Lozano, Andrés Gómez-De León, Guillermo J. Ruiz-Delgado, Raul C. Ribeiro
Publikováno v:
Hematology, Vol 27, Iss 1, Pp 971-976 (2022)
Objective to discuss the status and challenges associated with the management of acute lymphoblastic leukemia (ALL) in Latin America.Methods This review summarizes various insights gained from information regarding diagnostic approaches and treatment
Externí odkaz:
https://doaj.org/article/0707c327d8e348e2badc7532d9d74a96
Autor:
Paula Aristizabal, Rebeca Rivera-Gomez, Andrew Chang, Mario Ornelas, Maribel Ramirez, Gabriela Tamayo, Angelica Martinez, Raul C. Ribeiro, William Roberts
Publikováno v:
JCO Global Oncology, Vol , Iss 9 (2023)
PURPOSEPediatric leukemia outcomes are poor in most low- and middle-income countries (LMICs) and exacerbated by health care systems ill equipped to manage cancer. Effective leukemia management in LMICs involves curating epidemiologic data; providing
Externí odkaz:
https://doaj.org/article/53ee970667614d4881e9af3157882a80
Autor:
Carolina Hassibe Thomé, Germano Aguiar Ferreira, Diego Antonio Pereira-Martins, Guilherme Augusto dos Santos, César Alexander Ortiz, Lucas Eduardo Botelho de Souza, Lays Martins Sobral, Cleide Lúcia Araújo Silva, Priscila Santos Scheucher, Cristiane Damas Gil, Andréia Machado Leopoldino, Douglas R. A. Silveira, Juan L. Coelho-Silva, Fabíola Traina, Luisa C. Koury, Raul A. M. Melo, Rosane Bittencourt, Katia Pagnano, Ricardo Pasquini, Elenaide C. Nunes, Evandro M. Fagundes, Ana Beatriz F. Gloria, Fábio Rodrigues Kerbauy, Maria de Lourdes Chauffaille, Armand Keating, Martin S. Tallman, Raul C. Ribeiro, Richard Dillon, Arnold Ganser, Bob Löwenberg, Peter Valk, Francesco Lo-Coco, Miguel A. Sanz, Nancy Berliner, Vitor Marcel Faça, Eduardo M. Rego
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Non-T cell activation linker (NTAL) is a lipid raft-membrane protein expressed by normal and leukemic cells and involved in cell signaling. In acute promyelocytic leukemia (APL), NTAL depletion from lipid rafts decreases cell viability throu
Externí odkaz:
https://doaj.org/article/1687378c1dd345e09a5c08f24c483459
Autor:
Daelynn R. Buelow, Stanley B. Pounds, Yong‐Dong Wang, Lei Shi, Yongjin Li, David Finkelstein, Sheila Shurtleff, Geoffrey Neale, Hiroto Inaba, Raul C. Ribeiro, Reid Palumbo, Dominique Garrison, Shelley J. Orwick, James S. Blachly, Karl Kroll, John C. Byrd, Tanja A. Gruber, Jeffrey E. Rubnitz, Sharyn D. Baker
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 6, Pp 641-647 (2019)
Fms‐like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations, common in pediatric acute myeloid leukemia (AML), associate with early relapse and poor prognosis. Past studies have suggested additional cooperative mutations are requi
Externí odkaz:
https://doaj.org/article/b729c098fb6e48d4859209165db95c5f
Autor:
Emilia Modolo Pinto, Carlos Rodriguez-Galindo, Catherine G. Lam, Robert E. Ruiz, Gerard P. Zambetti, Raul C. Ribeiro
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Pediatric adrenocortical tumors (ACTs) are rare and heterogeneous. Approximately 50% of children with ACT carry a germline TP53 variant; however, the genetic underpinning of remaining cases has not been elucidated. In patients having germline TP53 va
Externí odkaz:
https://doaj.org/article/b185a85e41364ff1b358316a95e9282a
Autor:
Seth E. Karol, Deqing Pei, Colton A. Smith, Yiwei Liu, Wenjian Yang, Nancy M. Kornegay, John C. Panetta, Kristine R. Crews, Cheng Cheng, Emily R. Finch, Hiroto Inaba, Monika L. Metzger, Jeffrey E. Rubnitz, Raul C. Ribeiro, Tanja A. Gruber, Jun J. Yang, William E. Evans, Sima Jeha, Ching-Hon Pui, Mary V. Relling
Publikováno v:
Haematologica, Vol 107, Iss 2 (2021)
Chemotherapy dosages are often compromised, but most reports lack data on dosages that are actually delivered. In two consecutive acute lymphoblastic leukemia trials that differed in their asparaginase formulation, native E. coli L-asparaginase in St
Externí odkaz:
https://doaj.org/article/f2f424e701944bfb90237067ca32533f
Autor:
Christina D. Drenberg, Anang Shelat, Jinjun Dang, Anitria Cotton, Shelley J. Orwick, Mengyu Li, Jae Yoon Jeon, Qiang Fu, Daelynn R. Buelow, Marissa Pioso, Shuiying Hu, Hiroto Inaba, Raul C. Ribeiro, Jeffrey E. Rubnitz, Tanja A. Gruber, R. Kiplin Guy, Sharyn D. Baker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Pediatric AML is traditionally treated with chemotherapy and stem cell transplant but some subsets of patients have a poor response to therapy. Here, the authors perform a high throughput screen and identify several FDA approved drugs that might be u
Externí odkaz:
https://doaj.org/article/f909cbdab341455d9f702b6081a46e6f