Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Raul C Camacho"'
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126642 (2015)
Hyperinsulinemic-euglycemic clamps are considered the "gold standard" for assessing whole body insulin sensitivity. When used in combination with tracer dilution techniques and physiological insulin concentrations, insulin sensitization can be dissec
Externí odkaz:
https://doaj.org/article/b9cb24e16ca74f84ba18993fe907540a
Autor:
Raul C. Camacho, Seohee You, Katharine E. D’Aquino, Wenyu Li, Yuanping Wang, Joseph Gunnet, James Littrell, Jian Shen Qi, Lijuan Kang, Wenying Jian, Mary MacDonald, Timothy Tat, Derek Steiner, Yue-Mei Zhang, James Lanter, Raymond Patch, Rui Zhang, Jiali Li, Suzanne Edavettal, Wilson Edwards, Thai Dinh, Li Ying Wang, Judy Connor, Michael Hunter, Ellen Chi, Ronald V. Swanson, James N. Leonard, Martin A. Case
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The long circulating half-life and inherently bivalent architecture of IgGs provide an ideal vehicle for presenting otherwise short-lived G-protein-coupled receptor agonists in a format that enables avidity-driven enhancement of potency. Here, we des
Externí odkaz:
https://doaj.org/article/5eb7ffd685414dc1807d86d35890f6a4
Autor:
Raul C. Camacho, David Polidori, Tao Chen, Bin Chen, Helen Han Hsu, Bin Gao, Mathieu Marella, Mariusz Lubomirski, Traymon Beavers, Javier Cabrera, Peggy Wong, Andrea R. Nawrocki
Publikováno v:
Diabetes, obesitymetabolism.
In humans, weight loss and pioglitazone treatment improve nonalcoholic steatohepatitis (NASH). We developed an obese, insulin resistant cynomolgus monkey model of NASH with fibrosis with a high fat/high cholesterol (HFHC) diet (with or without high f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae45fae9b8e0b3dec5c97fe6d66a1b70
https://pubmed.ncbi.nlm.nih.gov/36546607
https://pubmed.ncbi.nlm.nih.gov/36546607
Autor:
null Raul C. Camacho, null David Polidori, null Tao Chen, null Bin Chen, null Helen Han Hsu, null Bin Gao, null Mathieu Marella, null Mariusz Lubomirski, null Traymon Beavers, null Javier Cabrera, null Peggy Wong, null Andrea R. Nawrocki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f669fd47d5477a421550b057e72c03
https://doi.org/10.1111/dom.14955/v2/response1
https://doi.org/10.1111/dom.14955/v2/response1
Autor:
Wilson Edwards, Yue-Mei Zhang, Shengsheng Xu, Raul C. Camacho, Wenying Jian, Lijuan Kang, Yongle Pang, Naidong Weng, Tom Kirchner, Norquay Lisa
Publikováno v:
Bioanalysis. 13:465-479
Aim: To further enhance the detection sensitivity and increase resolving power of top-down intact protein bioanalysis, middle-down approach was explored. Materials & methods: An monoclonal antibody (mAb) was used as a model protein to evaluate quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07eebf30af81ceefd19510b4a94293c5
https://doi.org/10.4155/bio-2020-0315
https://doi.org/10.4155/bio-2020-0315
Autor:
Songmao Zheng, Thomas Kirchner, George Ho, Xi Qiu, Fany Bonilla, Katharine D'Aquino, Wenyu Li, Peggy Wong, Zhang Rui, Wenying Jian, Raul C. Camacho, James Littrell, Bin Gao, James N. Leonard
Publikováno v:
Diabetes, Obesity and Metabolism. 22:2437-2450
Aim The aim of this study was to evaluate amino acids as glucagon receptor (GCGR)-specific biomarkers in rodents and cynomolgus monkeys in the presence of agonism of both glucagon-like peptide-1 receptor (GLP1R) and GCGR with a variety of dual agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a84e24ce805d32bafd3ea56db0578e
https://doi.org/10.1111/dom.14173
https://doi.org/10.1111/dom.14173
Autor:
null Wenyu Li, null Thomas Kirchner, null George Ho, null Fany Bonilla, null Katharine D'Aquino, null James Littrell, null Rui Zhang, null Wenying Jian, null Xi Qiu, null Songmao Zheng, null Peggy Wong, null James N. Leonard, null Raul C. Camacho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0abf75ad17c4f6e126a43d9779f31b9
https://doi.org/10.1111/dom.14173/v3/response1
https://doi.org/10.1111/dom.14173/v3/response1
Autor:
David Polidori, Raul C. Camacho, Tao Chen, Andrea R. Nawrocki, Peggy Wong, Edward Zhu, Tony Wang, Bin Gao, Joseph A. Gabriel
Publikováno v:
Diabetes. 69
Nonalcoholic fatty liver disease (NAFLD) ranges in severity from steatosis to NASH. NASH, which is characterized by steatosis, ballooning, inflammation (NAFLD Activity Score [NAS]), and frequently fibrosis, can progress to cirrhosis and hepatocellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61a5495212c73e6d328474a2fda46edf
https://doi.org/10.2337/db20-1827-p
https://doi.org/10.2337/db20-1827-p
Autor:
Jian Shen Qi, Thai Dinh, Timothy Tat, James Littrell, Ronald V. Swanson, Raul C. Camacho, Mary MacDonald, Ellen Chi, Lijuan Kang, Derek Steiner, Katharine D'Aquino, Jiali Li, Wenying Jian, Yue-Mei Zhang, James N. Leonard, Li Ying Wang, Yuanping Wang, Suzanne Edavettal, Michael J. Hunter, Wenyu Li, Case Martin A, Joseph Gunnet, Raymond J. Patch, Seohee You, Judy Connor, Wilson Edwards, Zhang Rui, James C. Lanter
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The long circulating half-life and inherently bivalent architecture of IgGs provide an ideal vehicle for presenting otherwise short-lived G-protein-coupled receptor agonists in a format that enables avidity-driven enhancement of potency. Here, we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c0ad01619c709ccaefd8edf1de67f3
https://doi.org/10.1080/19420862.2020.1794687
https://doi.org/10.1080/19420862.2020.1794687
Autor:
Christopher A. Teleha, Cuifen Hou, Michael N. Greco, Mark J. Macielag, Renee L. DesJarlais, Shuyuan Zhao, Yue-Mei Zhang, Keith T. Demarest, Yuting Tang, Jenson Qi, Cailin Chen, Jack Kauffman, William V. Murray, George Ho, Raul C. Camacho, James N. Leonard
Publikováno v:
Journal of Medicinal Chemistry. 61:10276-10298
A novel series of 6-benzhydryl-4-amino-quinolin-2-ones was discovered as cannabinoid type 1 receptor (CB1R) inverse agonists based on the high-throughput screening hit, compound 1a. Structure-activity relationships were studied to improve in vitro/in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0046bd786af1e015f911a9466803c035
https://doi.org/10.1021/acs.jmedchem.8b01467
https://doi.org/10.1021/acs.jmedchem.8b01467